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A8XA58 (CDK1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 1

Short name=CDK1
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division control protein 2 homolog
Cell division protein kinase 1
Gene names
Name:cdk-1
ORF Names:CBG10007
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity. UniProtKB P06493

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB P06493

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. UniProtKB P06493

Enzyme regulation

Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation By similarity. UniProtKB P34556

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 By similarity. UniProtKB P06493 UniProtKB P34556

Subcellular location

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity UniProtKB P39951.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Cyclin-dependent kinase 1
PRO_0000353199

Regions

Domain16 – 306291Protein kinase
Nucleotide binding22 – 309ATP By similarity

Sites

Active site1401Proton acceptor By similarity
Binding site451ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8XA58 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 46D6B9B2C3BA3727

FASTA32637,875
        10         20         30         40         50         60 
MTAIRKNDMN YTLDDFTKLE KIGEGTYGVV YKGRNRRTQA MVAMKKIRLE SEDEGVPSTA 

        70         80         90        100        110        120 
VREISLLKEL QHPNVVGLEA VIMQENRLYL IFEFLSYDLK RYMDTLSKEE YLPSETLKSY 

       130        140        150        160        170        180 
TFQILQAMCF CHQRRVIHRD LKPQNLLVDE KGAIKLADFG LARAIGIPIR VYTHEVVTLW 

       190        200        210        220        230        240 
YRAPEILMGA QRYSMGVDMW SIGCIFAEMA TKKPLFQGDS EIDELFRIFR ILGTPTELEW 

       250        260        270        280        290        300 
NGVESLPDYK ATFPKWRENF LRDKFYDKKS GNYLMDEDAF SLLEGLLIYD PALRISSKKA 

       310        320 
LHHPYFNDID TSKLPAGNYR GELQLE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601459 Genomic DNA. Translation: CAP29526.1.
RefSeqXP_002641677.1. XM_002641631.1.

3D structure databases

ProteinModelPortalA8XA58.
SMRA8XA58. Positions 12-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG10007.

Proteomic databases

PRIDEA8XA58.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG10007; CBG10007; CBG10007.
GeneID8583671.
KEGGcbr:CBG10007.

Organism-specific databases

CTD8583671.
WormBaseCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02087.
OMAPNNDVWP.
OrthoDBEOG7966H8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK1_CAEBR
AccessionPrimary (citable) accession number: A8XA58
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: March 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families