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A8XA58

- CDK1_CAEBR

UniProt

A8XA58 - CDK1_CAEBR

Protein

Cyclin-dependent kinase 1

Gene

cdk-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.By similarity

    Enzyme regulationi

    Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451ATPPROSITE-ProRule annotation
    Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein kinase binding Source: UniProtKB
    4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell division Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. positive regulation of meiotic cell cycle Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
    Short name:
    CDK1
    Alternative name(s):
    Cell division control protein 2 homologBy similarity
    Cell division protein kinase 1
    Gene namesi
    Name:cdk-1Imported
    ORF Names:CBG10007
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule organizing center Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Cyclin-dependent kinase 1PRO_0000353199Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA8XA58.

    Interactioni

    Subunit structurei

    Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG10007.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XA58.
    SMRiA8XA58. Positions 12-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 306291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK02087.
    OMAiGKMALKH.
    OrthoDBiEOG7966H8.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XA58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAIRKNDMN YTLDDFTKLE KIGEGTYGVV YKGRNRRTQA MVAMKKIRLE    50
    SEDEGVPSTA VREISLLKEL QHPNVVGLEA VIMQENRLYL IFEFLSYDLK 100
    RYMDTLSKEE YLPSETLKSY TFQILQAMCF CHQRRVIHRD LKPQNLLVDE 150
    KGAIKLADFG LARAIGIPIR VYTHEVVTLW YRAPEILMGA QRYSMGVDMW 200
    SIGCIFAEMA TKKPLFQGDS EIDELFRIFR ILGTPTELEW NGVESLPDYK 250
    ATFPKWRENF LRDKFYDKKS GNYLMDEDAF SLLEGLLIYD PALRISSKKA 300
    LHHPYFNDID TSKLPAGNYR GELQLE 326
    Length:326
    Mass (Da):37,875
    Last modified:January 15, 2008 - v1
    Checksum:i46D6B9B2C3BA3727
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601459 Genomic DNA. Translation: CAP29526.1.
    RefSeqiXP_002641677.1. XM_002641631.1.

    Genome annotation databases

    EnsemblMetazoaiCBG10007; CBG10007; CBG10007.
    GeneIDi8583671.
    KEGGicbr:CBG10007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601459 Genomic DNA. Translation: CAP29526.1 .
    RefSeqi XP_002641677.1. XM_002641631.1.

    3D structure databases

    ProteinModelPortali A8XA58.
    SMRi A8XA58. Positions 12-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG10007.

    Proteomic databases

    PRIDEi A8XA58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG10007 ; CBG10007 ; CBG10007 .
    GeneIDi 8583671.
    KEGGi cbr:CBG10007.

    Organism-specific databases

    CTDi 8583671.
    WormBasei CBG10007 ; CBP08360 ; WBGene00031495 ; Cbr-cdk-1.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K02087.
    OMAi GKMALKH.
    OrthoDBi EOG7966H8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiCDK1_CAEBR
    AccessioniPrimary (citable) accession number: A8XA58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3