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A8XA58

- CDK1_CAEBR

UniProt

A8XA58 - CDK1_CAEBR

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Protein

Cyclin-dependent kinase 1

Gene

cdk-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.By similarity

Enzyme regulationi

Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein kinase binding Source: UniProtKB
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell division Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. positive regulation of meiotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2 homologBy similarity
Cell division protein kinase 1
Gene namesi
Name:cdk-1Imported
ORF Names:CBG10007
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Cyclin-dependent kinase 1PRO_0000353199Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA8XA58.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi6238.CBG10007.

Structurei

3D structure databases

ProteinModelPortaliA8XA58.
SMRiA8XA58. Positions 12-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 306291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiA8XA58.
KOiK02087.
OMAiGKMALKH.
OrthoDBiEOG7966H8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XA58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAIRKNDMN YTLDDFTKLE KIGEGTYGVV YKGRNRRTQA MVAMKKIRLE
60 70 80 90 100
SEDEGVPSTA VREISLLKEL QHPNVVGLEA VIMQENRLYL IFEFLSYDLK
110 120 130 140 150
RYMDTLSKEE YLPSETLKSY TFQILQAMCF CHQRRVIHRD LKPQNLLVDE
160 170 180 190 200
KGAIKLADFG LARAIGIPIR VYTHEVVTLW YRAPEILMGA QRYSMGVDMW
210 220 230 240 250
SIGCIFAEMA TKKPLFQGDS EIDELFRIFR ILGTPTELEW NGVESLPDYK
260 270 280 290 300
ATFPKWRENF LRDKFYDKKS GNYLMDEDAF SLLEGLLIYD PALRISSKKA
310 320
LHHPYFNDID TSKLPAGNYR GELQLE
Length:326
Mass (Da):37,875
Last modified:January 15, 2008 - v1
Checksum:i46D6B9B2C3BA3727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1.
RefSeqiXP_002641677.1. XM_002641631.1.

Genome annotation databases

EnsemblMetazoaiCBG10007; CBG10007; CBG10007.
GeneIDi8583671.
KEGGicbr:CBG10007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1 .
RefSeqi XP_002641677.1. XM_002641631.1.

3D structure databases

ProteinModelPortali A8XA58.
SMRi A8XA58. Positions 12-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG10007.

Proteomic databases

PRIDEi A8XA58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG10007 ; CBG10007 ; CBG10007 .
GeneIDi 8583671.
KEGGi cbr:CBG10007.

Organism-specific databases

CTDi 8583671.
WormBasei CBG10007 ; CBP08360 ; WBGene00031495 ; Cbr-cdk-1.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi A8XA58.
KOi K02087.
OMAi GKMALKH.
OrthoDBi EOG7966H8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiCDK1_CAEBR
AccessioniPrimary (citable) accession number: A8XA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3