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A8XA58

- CDK1_CAEBR

UniProt

A8XA58 - CDK1_CAEBR

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Protein
Cyclin-dependent kinase 1
Gene
cdk-1, CBG10007
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.By similarity

Enzyme regulationi

Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATP By similarity
Active sitei140 – 1401Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  4. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. positive regulation of meiotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2 homolog
Cell division protein kinase 1
Gene namesi
Name:cdk-1
ORF Names:CBG10007
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule organizing center Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Cyclin-dependent kinase 1
PRO_0000353199Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA8XA58.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 By similarity.By similarity

Protein-protein interaction databases

STRINGi6238.CBG10007.

Structurei

3D structure databases

ProteinModelPortaliA8XA58.
SMRiA8XA58. Positions 12-315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 306291Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK02087.
OMAiGKMALKH.
OrthoDBiEOG7966H8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XA58-1 [UniParc]FASTAAdd to Basket

« Hide

MTAIRKNDMN YTLDDFTKLE KIGEGTYGVV YKGRNRRTQA MVAMKKIRLE    50
SEDEGVPSTA VREISLLKEL QHPNVVGLEA VIMQENRLYL IFEFLSYDLK 100
RYMDTLSKEE YLPSETLKSY TFQILQAMCF CHQRRVIHRD LKPQNLLVDE 150
KGAIKLADFG LARAIGIPIR VYTHEVVTLW YRAPEILMGA QRYSMGVDMW 200
SIGCIFAEMA TKKPLFQGDS EIDELFRIFR ILGTPTELEW NGVESLPDYK 250
ATFPKWRENF LRDKFYDKKS GNYLMDEDAF SLLEGLLIYD PALRISSKKA 300
LHHPYFNDID TSKLPAGNYR GELQLE 326
Length:326
Mass (Da):37,875
Last modified:January 15, 2008 - v1
Checksum:i46D6B9B2C3BA3727
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1.
RefSeqiXP_002641677.1. XM_002641631.1.

Genome annotation databases

EnsemblMetazoaiCBG10007; CBG10007; CBG10007.
GeneIDi8583671.
KEGGicbr:CBG10007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1 .
RefSeqi XP_002641677.1. XM_002641631.1.

3D structure databases

ProteinModelPortali A8XA58.
SMRi A8XA58. Positions 12-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG10007.

Proteomic databases

PRIDEi A8XA58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG10007 ; CBG10007 ; CBG10007 .
GeneIDi 8583671.
KEGGi cbr:CBG10007.

Organism-specific databases

CTDi 8583671.
WormBasei CBG10007 ; CBP08360 ; WBGene00031495 ; Cbr-cdk-1.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K02087.
OMAi GKMALKH.
OrthoDBi EOG7966H8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCDK1_CAEBR
AccessioniPrimary (citable) accession number: A8XA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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