Reviewed,
UniProtKB/Swiss-Prot A8XA58 (CDC2_CAEBR)
Last modified
February 9, 2010.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division control protein 2 homolog EC=2.7.11.22 EC=2.7.11.23 | ||||
| Gene names |
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| Organism | Caenorhabditis briggsae [Complete proteome] | ||||
| Taxonomic identifier | 6238 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 326 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity. UniProtKB P06493 |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. UniProtKB P06493 ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. UniProtKB P06493 |
| Enzyme regulation | Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation By similarity. UniProtKB P34556 |
| Subunit structure | Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 By similarity. UniProtKB P06493 UniProtKB P34556 |
| Subcellular location | Nucleus By similarity UniProtKB P39951. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 326 | 326 | Cell division control protein 2 homolog | PRO_0000353199 | |||||
Regions | |||||||||
| Domain | 16 – 306 | 291 | Protein kinase | ||||||
| Nucleotide binding | 22 – 30 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 140 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 45 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. Waterston R.H.PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CAAC02000489 Genomic DNA. Translation: CAP29526.1. |
| RefSeq | XP_002641677.1. |
3D structure databases | |
| SMR | A8XA58. Positions 12-315. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 8583671. |
Organism-specific databases | |
| WormBase | WBGene00031495. Cbr-cdk-1. |
Phylogenomic databases | |
| HOGENOM | HBG755340. |
| OMA | LPDYKAT. |
| PhylomeDB | A8XA58. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDC2_CAEBR | ||||||||
| Accession | Primary (citable) accession number: A8XA58 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||

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