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Protein

Cyclin-dependent kinase 1

Gene

cdk-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.By similarity

Enzyme regulationi

Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2 homologBy similarity
Cell division protein kinase 1
Gene namesi
Name:cdk-1Imported
ORF Names:CBG10007
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Cyclin-dependent kinase 1PRO_0000353199Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA8XA58.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi6238.CBG10007.

Structurei

3D structure databases

ProteinModelPortaliA8XA58.
SMRiA8XA58. Positions 12-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 306291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiA8XA58.
KOiK02087.
OMAiIPSGQYM.
OrthoDBiEOG7966H8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XA58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIRKNDMN YTLDDFTKLE KIGEGTYGVV YKGRNRRTQA MVAMKKIRLE
60 70 80 90 100
SEDEGVPSTA VREISLLKEL QHPNVVGLEA VIMQENRLYL IFEFLSYDLK
110 120 130 140 150
RYMDTLSKEE YLPSETLKSY TFQILQAMCF CHQRRVIHRD LKPQNLLVDE
160 170 180 190 200
KGAIKLADFG LARAIGIPIR VYTHEVVTLW YRAPEILMGA QRYSMGVDMW
210 220 230 240 250
SIGCIFAEMA TKKPLFQGDS EIDELFRIFR ILGTPTELEW NGVESLPDYK
260 270 280 290 300
ATFPKWRENF LRDKFYDKKS GNYLMDEDAF SLLEGLLIYD PALRISSKKA
310 320
LHHPYFNDID TSKLPAGNYR GELQLE
Length:326
Mass (Da):37,875
Last modified:January 15, 2008 - v1
Checksum:i46D6B9B2C3BA3727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1.
RefSeqiXP_002641677.1. XM_002641631.1.

Genome annotation databases

EnsemblMetazoaiCBG10007; CBG10007; CBG10007.
GeneIDi8583671.
KEGGicbr:CBG10007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29526.1.
RefSeqiXP_002641677.1. XM_002641631.1.

3D structure databases

ProteinModelPortaliA8XA58.
SMRiA8XA58. Positions 12-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG10007.

Proteomic databases

PRIDEiA8XA58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG10007; CBG10007; CBG10007.
GeneIDi8583671.
KEGGicbr:CBG10007.

Organism-specific databases

CTDi8583671.
WormBaseiCBG10007; CBP08360; WBGene00031495; Cbr-cdk-1.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiA8XA58.
KOiK02087.
OMAiIPSGQYM.
OrthoDBiEOG7966H8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiCDK1_CAEBR
AccessioniPrimary (citable) accession number: A8XA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.