Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calnexin

Gene

cnx-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Calcium; via carbonyl oxygenBy similarity
Binding sitei155 – 1551CarbohydrateBy similarity
Binding sitei157 – 1571CarbohydrateBy similarity
Binding sitei176 – 1761CarbohydrateBy similarity
Binding sitei207 – 2071CarbohydrateBy similarity
Metal bindingi427 – 4271CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CalnexinBy similarity
Gene namesi
Name:cnx-1Imported
ORF Names:CBG09987
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09987; CBP08355; WBGene00031476; Cbr-cnx-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei480 – 50021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 623602CalnexinSequence analysisPRO_0000416936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi151 ↔ 185By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi351 ↔ 357By similarity

Post-translational modificationi

Glycosylation is important for its biological activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09987.

Structurei

3D structure databases

ProteinModelPortaliA8XA40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati269 – 281131-1Sequence analysisAdd
BLAST
Repeati286 – 298131-2Sequence analysisAdd
BLAST
Repeati305 – 317131-3Sequence analysisAdd
BLAST
Repeati324 – 336131-4Sequence analysisAdd
BLAST
Repeati339 – 349112-1Sequence analysisAdd
BLAST
Repeati358 – 368112-2Sequence analysisAdd
BLAST
Repeati372 – 382112-3Sequence analysisAdd
BLAST
Repeati386 – 396112-4Sequence analysisAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni267 – 400134P domain (Extended arm)By similarityAdd
BLAST
Regioni269 – 336684 X approximate repeatsSequence analysisAdd
BLAST
Regioni339 – 396584 X approximate repeatsSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calreticulin family.Sequence analysis

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
HOGENOMiHOG000192436.
InParanoidiA8XA40.
KOiK08054.
OrthoDBiEOG77126Z.

Family and domain databases

Gene3Di2.10.250.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XA40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNRKWSFVF LTFLLVISVN ANDDVFEDED EASESGVEKD EFVPSNFVAP
60 70 80 90 100
KLADTSKPNF FDYFPVGSKI GQTWIKSLAK KDDVDSEIAK YNGEWSIGAP
110 120 130 140 150
TKVSIEGDYG LIVKTKARHH AIAAKLETPF VFGSNKFIAQ YDVKFEEGQE
160 170 180 190 200
CGGGYLKLLS EGAEKDLASF QDKTPYTIMF GPDKCGASGQ VHLIFRYKNP
210 220 230 240 250
VNGTVSEYHA KQPASIGTAY WDDHNTHLFT LVVKPTGEYS VSVDGKSLYY
260 270 280 290 300
GNMLSDISPS LTPPKEIFDE TDLKPEDWDE REQIEDETAS KPDDWDENEP
310 320 330 340 350
QNVVDESATK PYDWNEEENE LIPDPEAQKP QDWDEDMDGS WEAPLIDNPA
360 370 380 390 400
CKGLSGCGTW KPPTIKNPKY RGKWVRPKIA NPAYKGKWSP RLIDNPNYFE
410 420 430 440 450
PKPFDGLAPI SAVGIELWTM SENILFDNIL ITSSEQDASE IAKQTFYIKQ
460 470 480 490 500
QEEYRLAAAT GSSNGIFQQI VDATNEKPWL WAVYILCILL PLIAIGVFCF
510 520 530 540 550
GKGSKPAPNF AKKSDTYSPD DDRVPNLVDD QEEEIIAEDE EDNQPGPSGT
560 570 580 590 600
QNQPPIDEDE QDEVEQQPSS SKTASSESSS AAEEEDNDHV VHENEPVQPT
610 620
EEVAKKSPRV TGGAKRRTAR RGD
Length:623
Mass (Da):69,593
Last modified:April 18, 2012 - v3
Checksum:i7FF3E49D33C01F7B
GO

Sequence cautioni

The sequence CAP29507.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29507.2. Sequence problems.
RefSeqiXP_002641659.1. XM_002641613.1.

Genome annotation databases

EnsemblMetazoaiCBG09987; CBG09987; WBGene00031476.
GeneIDi8583652.
KEGGicbr:CBG09987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29507.2. Sequence problems.
RefSeqiXP_002641659.1. XM_002641613.1.

3D structure databases

ProteinModelPortaliA8XA40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG09987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG09987; CBG09987; WBGene00031476.
GeneIDi8583652.
KEGGicbr:CBG09987.

Organism-specific databases

CTDi8583652.
WormBaseiCBG09987; CBP08355; WBGene00031476; Cbr-cnx-1.

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
HOGENOMiHOG000192436.
InParanoidiA8XA40.
KOiK08054.
OrthoDBiEOG77126Z.

Family and domain databases

Gene3Di2.10.250.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCALX_CAEBR
AccessioniPrimary (citable) accession number: A8XA40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.