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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

gpdh-2

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211SubstrateUniRule annotation
Active sitei209 – 2091Proton acceptorUniRule annotation

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
Name:gpdh-2Imported
Synonyms:Cbr-gpdh-2Imported
ORF Names:CBG09958Imported, CBG_09958Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componenti: Chromosome III

Organism-specific databases

WormBaseiCBG09958; CBP02434; WBGene00031452; Cbr-gpdh-2.

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09958.

Structurei

3D structure databases

ProteinModelPortaliA8XA17.
SMRiA8XA17. Positions 1-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246855.
InParanoidiA8XA17.
KOiK00006.
OMAiEVANDNF.
OrthoDBiEOG7ZKSBS.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XA17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKKVTIIG SGNWGSAIAR IVGNTTKSFP DQFDPQVRMY VYEEIVNGEK
60 70 80 90 100
LSEVINTRHE NIKYLPGKIL PENVVAVTDL VKSCEGSNIL IFVVPHQFVK
110 120 130 140 150
GLCEKLVGKI PADTQAISLI KGVSTGGIER GGLKLISEEI KEILKIEVSV
160 170 180 190 200
LMGANLAPEV ANDNFCEATI GCKRKAEDGP LLKKLFHTDN FRINVVEDAH
210 220 230 240 250
TVELCGALKN VVACAAGFTD GLGYGDNTKA AVIRLGLMET TKFVEHYYPG
260 270 280 290 300
SNLETFFESC GIADLITTCY GGRNRKVCEA FVKTGKTLAE VEKELLNGQS
310 320 330 340 350
AQGPLTAEEV YLMMKKTGLD AKFPLFTAVH KICAGEMKPA ELVDCLRNHP

EHM
Length:353
Mass (Da):38,467
Last modified:January 15, 2008 - v1
Checksum:i0EAB0D53A386CF45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29482.1.
RefSeqiXP_002641636.1. XM_002641590.1.

Genome annotation databases

EnsemblMetazoaiCBG09958; CBG09958; CBG09958.
GeneIDi8583627.
KEGGicbr:CBG09958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601459 Genomic DNA. Translation: CAP29482.1.
RefSeqiXP_002641636.1. XM_002641590.1.

3D structure databases

ProteinModelPortaliA8XA17.
SMRiA8XA17. Positions 1-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG09958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG09958; CBG09958; CBG09958.
GeneIDi8583627.
KEGGicbr:CBG09958.

Organism-specific databases

CTDi8583627.
WormBaseiCBG09958; CBP02434; WBGene00031452; Cbr-gpdh-2.

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246855.
InParanoidiA8XA17.
KOiK00006.
OMAiEVANDNF.
OrthoDBiEOG7ZKSBS.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiA8XA17_CAEBR
AccessioniPrimary (citable) accession number: A8XA17
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 29, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.