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A8X8R3

- PORED_CAEBR

UniProt

A8X8R3 - PORED_CAEBR

Protein

Polyprenol reductase

Gene

CBG09584

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.By similarity

    Catalytic activityi

    Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

    GO - Biological processi

    1. dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
    2. dolichol metabolic process Source: UniProtKB
    3. polyprenol catabolic process Source: UniProtKB
    4. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyprenol reductase (EC:1.3.1.94)
    Gene namesi
    ORF Names:CBG09584
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG09584; CBP16536; WBGene00031145.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Polyprenol reductasePRO_0000398652Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG09584.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330066.
    HOGENOMiHOG000018885.
    KOiK12345.
    OMAiFAAVQTH.
    OrthoDBiEOG72ZCFT.

    Family and domain databases

    InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8X8R3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLENLWEVRQ ALPIYLLTAT IGLAVSCCFT LICPHVCRLI PALTTYGKAA    50
    DQLEENSLVA RISVPKKWFK HFYALGLLTL LLCLHCIHSL IHNPDFLPTI 100
    PIKFLTILTR SYSIPPIAPS TAVLALLLIT FHVARRLYET LFVSVYSDSR 150
    MNVFHYIVGI VHYIILPISI MCETQGVITK KEIFHVSVDD ITLTQWAGAV 200
    LFWVCNWKQH QIAEQIANTR KGPRGLIRNY AYGICFGRWF NLVSCPHFLF 250
    EICIYLSLLL VIPTAYVYRF VVLFVCVNQT FAALITHSWY HKTFPKYPKT 300
    RKALIPYVL 309
    Length:309
    Mass (Da):35,465
    Last modified:January 15, 2008 - v1
    Checksum:i029B3D93687AA98B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600998 Genomic DNA. Translation: CAP29024.1.
    RefSeqiXP_002637085.1. XM_002637039.1.

    Genome annotation databases

    EnsemblMetazoaiCBG09584; CBG09584; CBG09584.
    GeneIDi8579081.
    KEGGicbr:CBG09584.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600998 Genomic DNA. Translation: CAP29024.1 .
    RefSeqi XP_002637085.1. XM_002637039.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG09584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG09584 ; CBG09584 ; CBG09584 .
    GeneIDi 8579081.
    KEGGi cbr:CBG09584.

    Organism-specific databases

    CTDi 8579081.
    WormBasei CBG09584 ; CBP16536 ; WBGene00031145 .

    Phylogenomic databases

    eggNOGi NOG330066.
    HOGENOMi HOG000018885.
    KOi K12345.
    OMAi FAAVQTH.
    OrthoDBi EOG72ZCFT.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiPORED_CAEBR
    AccessioniPrimary (citable) accession number: A8X8R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3