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A8X8R3

- PORED_CAEBR

UniProt

A8X8R3 - PORED_CAEBR

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Protein

Polyprenol reductase

Gene

CBG09584

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.By similarity

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

GO - Biological processi

  1. dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
  2. dolichol metabolic process Source: UniProtKB
  3. polyprenol catabolic process Source: UniProtKB
  4. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
Gene namesi
ORF Names:CBG09584
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG09584; CBP16536; WBGene00031145.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Polyprenol reductasePRO_0000398652Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09584.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330066.
HOGENOMiHOG000018885.
InParanoidiA8X8R3.
KOiK12345.
OMAiFAAVQTH.
OrthoDBiEOG72ZCFT.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8X8R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLENLWEVRQ ALPIYLLTAT IGLAVSCCFT LICPHVCRLI PALTTYGKAA
60 70 80 90 100
DQLEENSLVA RISVPKKWFK HFYALGLLTL LLCLHCIHSL IHNPDFLPTI
110 120 130 140 150
PIKFLTILTR SYSIPPIAPS TAVLALLLIT FHVARRLYET LFVSVYSDSR
160 170 180 190 200
MNVFHYIVGI VHYIILPISI MCETQGVITK KEIFHVSVDD ITLTQWAGAV
210 220 230 240 250
LFWVCNWKQH QIAEQIANTR KGPRGLIRNY AYGICFGRWF NLVSCPHFLF
260 270 280 290 300
EICIYLSLLL VIPTAYVYRF VVLFVCVNQT FAALITHSWY HKTFPKYPKT

RKALIPYVL
Length:309
Mass (Da):35,465
Last modified:January 15, 2008 - v1
Checksum:i029B3D93687AA98B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600998 Genomic DNA. Translation: CAP29024.1.
RefSeqiXP_002637085.1. XM_002637039.1.

Genome annotation databases

EnsemblMetazoaiCBG09584; CBG09584; CBG09584.
GeneIDi8579081.
KEGGicbr:CBG09584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600998 Genomic DNA. Translation: CAP29024.1 .
RefSeqi XP_002637085.1. XM_002637039.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG09584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG09584 ; CBG09584 ; CBG09584 .
GeneIDi 8579081.
KEGGi cbr:CBG09584.

Organism-specific databases

CTDi 8579081.
WormBasei CBG09584 ; CBP16536 ; WBGene00031145 .

Phylogenomic databases

eggNOGi NOG330066.
HOGENOMi HOG000018885.
InParanoidi A8X8R3.
KOi K12345.
OMAi FAAVQTH.
OrthoDBi EOG72ZCFT.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiPORED_CAEBR
AccessioniPrimary (citable) accession number: A8X8R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3