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A8X8R3 (PORED_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyprenol reductase

EC=1.3.1.94
Gene names
ORF Names:CBG09584
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activity

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Polyprenol reductase
PRO_0000398652

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane270 – 29021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8X8R3 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 029B3D93687AA98B

FASTA30935,465
        10         20         30         40         50         60 
MLENLWEVRQ ALPIYLLTAT IGLAVSCCFT LICPHVCRLI PALTTYGKAA DQLEENSLVA 

        70         80         90        100        110        120 
RISVPKKWFK HFYALGLLTL LLCLHCIHSL IHNPDFLPTI PIKFLTILTR SYSIPPIAPS 

       130        140        150        160        170        180 
TAVLALLLIT FHVARRLYET LFVSVYSDSR MNVFHYIVGI VHYIILPISI MCETQGVITK 

       190        200        210        220        230        240 
KEIFHVSVDD ITLTQWAGAV LFWVCNWKQH QIAEQIANTR KGPRGLIRNY AYGICFGRWF 

       250        260        270        280        290        300 
NLVSCPHFLF EICIYLSLLL VIPTAYVYRF VVLFVCVNQT FAALITHSWY HKTFPKYPKT 


RKALIPYVL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600998 Genomic DNA. Translation: CAP29024.1.
RefSeqXP_002637085.1. XM_002637039.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG09584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG09584; CBG09584; CBG09584.
GeneID8579081.
KEGGcbr:CBG09584.

Organism-specific databases

CTD8579081.
WormBaseCBG09584; CBP16536; WBGene00031145.

Phylogenomic databases

eggNOGNOG330066.
HOGENOMHOG000018885.
KOK12345.
OMATHKWYLQ.
OrthoDBEOG72ZCFT.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePORED_CAEBR
AccessionPrimary (citable) accession number: A8X8R3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways