A8X8D0 (CYP9_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase 9
Short name=PPIase 9
EC=5.2.1.8

Alternative name(s):
Cyclophilin-9
Rotamase 9

Gene names

Name:	cyn-9
Synonyms:	cyp-9
ORF Names:	CBG09202

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imid ic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens By similarity. UniProtKB Q09637
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). UniProtKB Q09637
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.
Sequence caution	The sequence CAB40202.1 differs from that shown. Reason: Erroneous gene model prediction. UniProtKB Q09637

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Peptidyl-prolyl cis-trans isomerase 9		PRO_0000332946
Regions
	Domain	9 – 174	166	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	A8X8D0 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 06AA294B751FFCA3	FASTA	313	35,787
	10 20 30 40 50 60 MSSLEKRVFL DMALDEKPIG RIEIKLFTSE APKTCENFRA LCTGEVGMAP NNKARLHYKG 70 80 90 100 110 120 NEIHRVVKKF MIQGGDITDG DGRGGFSIYG RYFDDEKFVL KHSKPYLLSM ANKGPNSNSS 130 140 150 160 170 180 QFFITTAPAP HCNGKHVVFG EVIKGREVVD VLDNLEVDGK SKPIAKVRIF NSGELVKKKK 190 200 210 220 230 240 PSKTKEELAA LEERKRQEAK KDIPDIPKSW LYRDNEERES DFSSKTESSR VRSRSKSPSN 250 260 270 280 290 300 NYETRRGHMA NSRGDRNRRT QRADRKDDFG IAVRGRGGVQ FRRVRYVTPE HWRRNAPSKW 310 QQGSYTHPVD LQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.
[2]	"A highly conserved nematode protein folding operon in Caenorhabditis elegans and Caenorhabditis briggsae." Page A.P. Gene 230:267-275(1999) [PubMed: 10216266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-249, NUCLEOTIDE SEQUENCE [MRNA] OF 1-141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000487 Genomic DNA. Translation: CAP28891.2. AJ005807 Genomic DNA. Translation: CAB40202.1. Sequence problems. AJ005809 mRNA. Translation: CAB40206.1.
3D structure databases
ProteinModelPortal	A8X8D0.
SMR	A8X8D0. Positions 5-178.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
WormBase	CBG09202; CBP25106; WBGene00030832.
Phylogenomic databases
HOGENOM	HBG610621.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. False negative. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP9_CAEBR

Accession

Primary (citable) accession number: A8X8D0
Secondary accession number(s): Q9XTP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project