A8X7X9 (T23O_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2,3-dioxygenase
Short name=TDO
EC=1.13.11.11

Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase

Gene names

ORF Names:

CBG09046

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process to kynurenine Inferred from electronic annotation. Source: InterPro
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro tryptophan 2,3-dioxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Tryptophan 2,3-dioxygenase		PRO_0000360076
Regions
	Region	40 – 44	5	Substrate binding By similarity
	Region	70 – 74	5	Substrate binding By similarity
Sites
	Metal binding	328	1	Iron (heme axial ligand) By similarity
	Binding site	141	1	Substrate By similarity
	Binding site	148	1	Heme By similarity
	Binding site	342	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8X7X9 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: B648B49A4E18D250	FASTA	404	46,862
	10 20 30 40 50 60 MACPYMNGGD TLPHRVTFME GGEECQQGVN KVEMGFGQTY PEYLQLDKIL TAQKLKSEAD 70 80 90 100 110 120 GQRVDDEHLF IVIHQAHELW FKQIIFDLDI VRKLLNNTIV DETKTLKIVS GLDRIVKILS 130 140 150 160 170 180 LLTEQITLLD TMSPLDFVDF RKYLTPASGF QSLQFRILEN KLGVKQERRI KYNAQHYKNV 190 200 210 220 230 240 FNDDDLKALN TTEDEKSLLT LIESWLERTP GLKSTSEDEG FWSKYESSVN KYLSDLAKQA 250 260 270 280 290 300 EDPSNTEEIK KQLRAEYSKT SDAFQSILDP RQHEQHIRNG NRLLSHDATK GAMMIYFYRD 310 320 330 340 350 360 MPRFSQPYQI LTFLMDIDSL FTKWRYNHVL LVQRMLGAKQ GTGGSSGYMY LRSTVSDRYK 370 380 390 400 VFLDLFNLST WLIPREYIPM LSPRMVKTLS EHSNLSHSQS SESE

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000485 Genomic DNA. Translation: CAP28740.1.
RefSeq	XP_002641185.1. XM_002641139.1.
3D structure databases
ProteinModelPortal	A8X7X9.
ModBase	Search...
Protein-protein interaction databases
STRING	A8X7X9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8583178.
KEGG	cbr:CBG09046.
Organism-specific databases
CTD	8583178.
WormBase	CBG09046; CBP02210; WBGene00030713.
Phylogenomic databases
HOGENOM	HBG647485.
OMA	KLLVDQV.
PhylomeDB	A8X7X9.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
KO	K00453.
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_CAEBR

Accession

Primary (citable) accession number: A8X7X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	January 15, 2008
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project