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A8X7W2

- A8X7W2_CAEBR

UniProt

A8X7W2 - A8X7W2_CAEBR

Protein

Histone deacetylase

Gene

CBG09063

Organism
Caenorhabditis briggsae
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    ORF Names:CBG09063Imported, CBG_09063Imported
    OrganismiCaenorhabditis briggsaeImported
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III

    Organism-specific databases

    WormBaseiCBG09063; CBP08173; WBGene00030730.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG09063.

    Structurei

    3D structure databases

    ProteinModelPortaliA8X7W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225180.
    KOiK06067.
    OMAiFNNYYEY.
    OrthoDBiEOG7DNNTW.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    A8X7W2-1 [UniParc]FASTAAdd to Basket

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    MVAPAPLRDQ SKRRVCYYYD TNVGNYYYGP GHVMKPHRIR MANELILSYG    50
    LYQNLSIYRP RPASFEAMTT FHSDEYITFL RDANIDNLNS FGASKGKFSQ 100
    NNDDCPLFDG LYEFCQLSCG GSLAAAIKLN KKKTDIAINW MGGLHHAKKS 150
    ESSGFCYTND IVVGILELLK FHKRVLYVDI DIHHGDGVEE AFFDTNRVMT 200
    VSFHRFGNFF PGTGDIKDVG IYNGRLYSVN VPLSDGITDE SYERIFVPVM 250
    KKVMEMFDPQ AVVLQCGADS LYGDRLGKFN LSLRGHGACA EFFRKYDVPL 300
    MMVGGGGYTP RNVARCWAYE TSIAVGIEVP NELPFNNYYE YFGPDYKLHI 350
    EPSQVLKNDN PDQKLLELQK EIFENLSQLD KVPSVQMQPM EDDTLPVLEF 400
    EDIARDEENP DVRLPMSIMD SCQHNDADFY DDENGGDDHR NEANGLRQAE 450
    AENNL 455
    Length:455
    Mass (Da):51,696
    Last modified:January 15, 2008 - v1
    Checksum:iF47EEA3536489432
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601284 Genomic DNA. Translation: CAP28723.1.
    RefSeqiXP_002641202.1. XM_002641156.1.

    Genome annotation databases

    EnsemblMetazoaiCBG09063; CBG09063; CBG09063.
    GeneIDi8583195.
    KEGGicbr:CBG09063.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601284 Genomic DNA. Translation: CAP28723.1 .
    RefSeqi XP_002641202.1. XM_002641156.1.

    3D structure databases

    ProteinModelPortali A8X7W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG09063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG09063 ; CBG09063 ; CBG09063 .
    GeneIDi 8583195.
    KEGGi cbr:CBG09063.

    Organism-specific databases

    CTDi 8583195.
    WormBasei CBG09063 ; CBP08173 ; WBGene00030730 .

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225180.
    KOi K06067.
    OMAi FNNYYEY.
    OrthoDBi EOG7DNNTW.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiA8X7W2_CAEBR
    AccessioniPrimary (citable) accession number: A8X7W2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3