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Protein

Histone deacetylase

Gene

CBG09063

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104SubstrateUniRule annotation1
Active sitei146Proton acceptorUniRule annotation1
Binding sitei154Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi181Divalent metal cationUniRule annotation1
Metal bindingi183Divalent metal cationUniRule annotation1
Metal bindingi269Divalent metal cationUniRule annotation1
Binding sitei308SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:CBG09063Imported, CBG_09063Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componenti: Chromosome III

Organism-specific databases

WormBaseiCBG09063; CBP08173; WBGene00030730.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG09063.

Structurei

3D structure databases

ProteinModelPortaliA8X7W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 323Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiA8X7W2.
KOiK06067.
OMAiDAHASWR.
OrthoDBiEOG091G067J.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A8X7W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPAPLRDQ SKRRVCYYYD TNVGNYYYGP GHVMKPHRIR MANELILSYG
60 70 80 90 100
LYQNLSIYRP RPASFEAMTT FHSDEYITFL RDANIDNLNS FGASKGKFSQ
110 120 130 140 150
NNDDCPLFDG LYEFCQLSCG GSLAAAIKLN KKKTDIAINW MGGLHHAKKS
160 170 180 190 200
ESSGFCYTND IVVGILELLK FHKRVLYVDI DIHHGDGVEE AFFDTNRVMT
210 220 230 240 250
VSFHRFGNFF PGTGDIKDVG IYNGRLYSVN VPLSDGITDE SYERIFVPVM
260 270 280 290 300
KKVMEMFDPQ AVVLQCGADS LYGDRLGKFN LSLRGHGACA EFFRKYDVPL
310 320 330 340 350
MMVGGGGYTP RNVARCWAYE TSIAVGIEVP NELPFNNYYE YFGPDYKLHI
360 370 380 390 400
EPSQVLKNDN PDQKLLELQK EIFENLSQLD KVPSVQMQPM EDDTLPVLEF
410 420 430 440 450
EDIARDEENP DVRLPMSIMD SCQHNDADFY DDENGGDDHR NEANGLRQAE

AENNL
Length:455
Mass (Da):51,696
Last modified:January 15, 2008 - v1
Checksum:iF47EEA3536489432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601284 Genomic DNA. Translation: CAP28723.1.
RefSeqiXP_002641202.1. XM_002641156.1.

Genome annotation databases

EnsemblMetazoaiCBG09063; CBG09063; WBGene00030730.
GeneIDi8583195.
KEGGicbr:CBG09063.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8X7W2_CAEBR
AccessioniPrimary (citable) accession number: A8X7W2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 5, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported