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Protein

Glycogen synthase kinase-3

Gene

gsk-3

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension (By similarity).By similarity

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65ATPPROSITE-ProRule annotation1
Active sitei161Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 50ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processStress response, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase kinase-3By similarity (EC:2.7.11.26)
Gene namesi
Name:gsk-3
ORF Names:CBG07972
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome I, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG07972 ; CBP01995 ; WBGene00029853 ; Cbr-gsk-3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491351 – 359Glycogen synthase kinase-3Add BLAST359

Proteomic databases

PRIDEiA8X5H5

Interactioni

Subunit structurei

Monomer. Interacts with axl-1.By similarity

Protein-protein interaction databases

STRINGi6238.CBG07972

Structurei

3D structure databases

ProteinModelPortaliA8X5H5
SMRiA8X5H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
InParanoidiA8X5H5
KOiK03083
OMAiHARRHCG
OrthoDBiEOG091G099S

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A8X5H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV
60 70 80 90 100
FLAKLSTTNE MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG
110 120 130 140 150
DKKDELYLNL ILEYVPETVY RVARHYSKQR QSIPMIYVKL YMYQLLRSLA
160 170 180 190 200
YIHSIGICHR DIKPQNLLID PETGILKLCD FGSAKYLVRN EPNVSYICSR
210 220 230 240 250
YYRAPELIFG ATNYTNSIDV WSAGTVIAEL LLGQPIFPGD SGVDQLVEII
260 270 280 290 300
KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI
310 320 330 340 350
IEYTPTSRPT PQAACQHAFF DELRSPDARL PSGRALPQLE MDGPNEVSAT

GGDMAGPSA
Length:359
Mass (Da):40,551
Last modified:January 15, 2008 - v1
Checksum:iF60E3D91F8D651EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600996 Genomic DNA Translation: CAP27886.1
RefSeqiXP_002646100.1, XM_002646054.1

Genome annotation databases

EnsemblMetazoaiCBG07972; CBG07972; WBGene00029853
GeneIDi8588159
KEGGicbr:CBG07972

Similar proteinsi

Entry informationi

Entry nameiGSK3_CAEBR
AccessioniPrimary (citable) accession number: A8X5H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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