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A8X5H5

- GSK3_CAEBR

UniProt

A8X5H5 - GSK3_CAEBR

Protein

Glycogen synthase kinase-3

Gene

gsk-3

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension By similarity.By similarity

    Catalytic activityi

    ATP + [tau protein] = ADP + [tau protein] phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651ATPPROSITE-ProRule annotation
    Active sitei161 – 1611Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi42 – 509ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW
    3. tau-protein kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: UniProtKB
    2. locomotion Source: UniProtKB
    3. mitotic spindle organization Source: UniProtKB
    4. negative regulation of Wnt signaling pathway Source: UniProtKB
    5. nematode larval development Source: UniProtKB
    6. positive regulation of growth rate Source: UniProtKB
    7. response to stress Source: UniProtKB-KW
    8. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Stress response, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen synthase kinase-3By similarity (EC:2.7.11.26)
    Gene namesi
    Name:gsk-3
    ORF Names:CBG07972
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG07972; CBP01995; WBGene00029853; Cbr-gsk-3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Glycogen synthase kinase-3PRO_0000349135Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Interacts with axl-1.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG07972.

    Structurei

    3D structure databases

    ProteinModelPortaliA8X5H5.
    SMRiA8X5H5. Positions 11-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 320285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK03083.
    OMAiKIIEYTP.
    OrthoDBiEOG7TF78V.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8X5H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV    50
    FLAKLSTTNE MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG 100
    DKKDELYLNL ILEYVPETVY RVARHYSKQR QSIPMIYVKL YMYQLLRSLA 150
    YIHSIGICHR DIKPQNLLID PETGILKLCD FGSAKYLVRN EPNVSYICSR 200
    YYRAPELIFG ATNYTNSIDV WSAGTVIAEL LLGQPIFPGD SGVDQLVEII 250
    KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI 300
    IEYTPTSRPT PQAACQHAFF DELRSPDARL PSGRALPQLE MDGPNEVSAT 350
    GGDMAGPSA 359
    Length:359
    Mass (Da):40,551
    Last modified:January 15, 2008 - v1
    Checksum:iF60E3D91F8D651EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600996 Genomic DNA. Translation: CAP27886.1.
    RefSeqiXP_002646100.1. XM_002646054.1.

    Genome annotation databases

    EnsemblMetazoaiCBG07972; CBG07972; CBG07972.
    GeneIDi8588159.
    KEGGicbr:CBG07972.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600996 Genomic DNA. Translation: CAP27886.1 .
    RefSeqi XP_002646100.1. XM_002646054.1.

    3D structure databases

    ProteinModelPortali A8X5H5.
    SMRi A8X5H5. Positions 11-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG07972.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG07972 ; CBG07972 ; CBG07972 .
    GeneIDi 8588159.
    KEGGi cbr:CBG07972.

    Organism-specific databases

    CTDi 8588159.
    WormBasei CBG07972 ; CBP01995 ; WBGene00029853 ; Cbr-gsk-3.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K03083.
    OMAi KIIEYTP.
    OrthoDBi EOG7TF78V.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiGSK3_CAEBR
    AccessioniPrimary (citable) accession number: A8X5H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3