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A8X5H5 (GSK3_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycogen synthase kinase-3

EC=2.7.11.26
Gene names
Name:gsk-3
ORF Names:CBG07972
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension By similarity. UniProtKB Q9U2Q9

Catalytic activity

ATP + [tau protein] = ADP + [tau protein] phosphate. UniProtKB P49841

Subunit structure

Monomer By similarity. Interacts with axl-1 By similarity. UniProtKB Q9WV60 UniProtKB Q9U2Q9

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Glycogen synthase kinase-3
PRO_0000349135

Regions

Domain36 – 320285Protein kinase
Nucleotide binding42 – 509ATP By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site651ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8X5H5 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: F60E3D91F8D651EE

FASTA35940,551
        10         20         30         40         50         60 
MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV FLAKLSTTNE 

        70         80         90        100        110        120 
MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG DKKDELYLNL ILEYVPETVY 

       130        140        150        160        170        180 
RVARHYSKQR QSIPMIYVKL YMYQLLRSLA YIHSIGICHR DIKPQNLLID PETGILKLCD 

       190        200        210        220        230        240 
FGSAKYLVRN EPNVSYICSR YYRAPELIFG ATNYTNSIDV WSAGTVIAEL LLGQPIFPGD 

       250        260        270        280        290        300 
SGVDQLVEII KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI 

       310        320        330        340        350 
IEYTPTSRPT PQAACQHAFF DELRSPDARL PSGRALPQLE MDGPNEVSAT GGDMAGPSA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600996 Genomic DNA. Translation: CAP27886.1.
RefSeqXP_002646100.1. XM_002646054.1.

3D structure databases

ProteinModelPortalA8X5H5.
SMRA8X5H5. Positions 11-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG07972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG07972; CBG07972; CBG07972.
GeneID8588159.
KEGGcbr:CBG07972.

Organism-specific databases

CTD8588159.
WormBaseCBG07972; CBP01995; WBGene00029853; Cbr-gsk-3.

Phylogenomic databases

eggNOGCOG0515.
KOK03083.
OMADELRCHG.
OrthoDBEOG7TF78V.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSK3_CAEBR
AccessionPrimary (citable) accession number: A8X5H5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families