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Protein

Serine/threonine-protein kinase par-1

Gene

par-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571ATPPROSITE-ProRule annotationBy similarity
Active sitei250 – 2501Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 1429ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase par-1By similarityImported (EC:2.7.11.1)
Gene namesi
Name:par-1
ORF Names:CBG04756
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome V, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG04756; CBP01266; WBGene00027371; Cbr-par-1.

Subcellular locationi

  • Cytoplasmcell cortex By similarity

  • Note: Colocalizes with germ granules (P granules).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10881088Serine/threonine-protein kinase par-1PRO_0000383321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG04756.

Structurei

3D structure databases

ProteinModelPortaliA8WYE4.
SMRiA8WYE4. Positions 115-442, 992-1088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 379252Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini398 – 44043UBAPROSITE-ProRule annotationAdd
BLAST
Domaini1039 – 108850KA1PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 114113Ser-richSequence analysisAdd
BLAST
Compositional biasi736 – 82994Ser-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 KA1 (kinase-associated) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000233025.
InParanoidiA8WYE4.
KOiK08798.
OMAiEGTIWSK.
OrthoDBiEOG79CXXX.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 3 hits.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8WYE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVSSYFMG ISSKKNGSSA TANKQSTRPQ ESHHHRRQQP TSQQSTEMNG
60 70 80 90 100
TTTAPSGGTS SGTTTTSSGV PTASTGGGSA RYSSSSSGRS HPTTGGGSSS
110 120 130 140 150
HARSSGQSGM SSRSAARRND QDVHVGKYKL LKTIGKGNFA KVKLAKHVIT
160 170 180 190 200
GHEVAIKIID KTALNPSSLQ KLFREVKIMK QLDHPNIVKL YQVMETEQTL
210 220 230 240 250
YLVLEYASGG EVFDYLVAHG RMKEKEARAK FRQIVSAVQY LHSKNIIHRD
260 270 280 290 300
LKAENLLLDQ DMNIKIADFG FSNTFSLGNK LDTFCGSPPY AAPELFSGKK
310 320 330 340 350
YDGPEVDVWS LGVILYTLVS GSLPFDGQNL KELRERVLRG KYRIPFYMST
360 370 380 390 400
DCENLLKKFL VINPQRRSSL DNIMKDRWMN VGYEDDELKP FIEPPKDQID
410 420 430 440 450
EQRIEKLIQI FQLGFNKATI LESVEKEKFE DIHATYLLLG ERKSDPSRYS
460 470 480 490 500
RSSATATGPS ITSGAALASA ANAQKHQSSA APASGSSSSR RSSQNDAAAS
510 520 530 540 550
GAGGTVVMSG TRHGGVQMRA QPTSRQAAIS LLQPPSYKPS SNTTQIAQIP
560 570 580 590 600
PLFNRNSTAT SSTNQPSSGI TAGTRKIDPK GRIPLNSAAV QSHRTATGAV
610 620 630 640 650
AANTGGIPSQ RDHSQQQQQY MNQLTSSSMM SKLINKTPAA GGANATTSAT
660 670 680 690 700
SAAAAPLQKS GSQISHAPTE PVIREDDDES NSEHQNGNVP LIGGVGPQTS
710 720 730 740 750
PVVAPSEDVT SSEQQKQEKA SSEAPKETKP SMIHQSPSMP PSQMMTAMES
760 770 780 790 800
LKLSESGGKS PSNSQQPPQR ATSQQMSRSA TTNSAANMAS NQQSSGAPQQ
810 820 830 840 850
SGASSQQCHT KPSSTSSSSS SSTTAPTSSG QPHHQHQLTH NASFSVTPSA
860 870 880 890 900
YQMPTTTTIT SGAPTSSSAF PRNTRNRQTF HGKTEKDKGG DDGSDEIGDT
910 920 930 940 950
PANVSIGATG ASANNTEGTI WSKLSKLTRR DHNRESMTQP VSSRAGTIGA
960 970 980 990 1000
AQGQQTAAAL AAIREQSSGP LTPGTPPVAQ AMTQEGDVKP RSLRFTWSMK
1010 1020 1030 1040 1050
TTSSLAPDDM MREIRKVLDA NGCDYEQRER YMILCVHGDP NTDSLVQWEM
1060 1070 1080
EVCKLPRLSL NGVRFKRISG TSIGFKNIAS KIAQELNL
Length:1,088
Mass (Da):116,525
Last modified:January 15, 2008 - v1
Checksum:i805A332FC0C22850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601135 Genomic DNA. Translation: CAP25402.1.
RefSeqiXP_002637943.1. XM_002637897.1.

Genome annotation databases

EnsemblMetazoaiCBG04756; CBG04756; WBGene00027371.
GeneIDi8579940.
KEGGicbr:CBG04756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601135 Genomic DNA. Translation: CAP25402.1.
RefSeqiXP_002637943.1. XM_002637897.1.

3D structure databases

ProteinModelPortaliA8WYE4.
SMRiA8WYE4. Positions 115-442, 992-1088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG04756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG04756; CBG04756; WBGene00027371.
GeneIDi8579940.
KEGGicbr:CBG04756.

Organism-specific databases

CTDi8579940.
WormBaseiCBG04756; CBP01266; WBGene00027371; Cbr-par-1.

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
HOGENOMiHOG000233025.
InParanoidiA8WYE4.
KOiK08798.
OMAiEGTIWSK.
OrthoDBiEOG79CXXX.

Family and domain databases

Gene3Di3.30.310.80. 1 hit.
InterProiIPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PANTHERiPTHR24346. PTHR24346. 3 hits.
PfamiPF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiPAR1_CAEBR
AccessioniPrimary (citable) accession number: A8WYE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.