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Protein

Serine/threonine-protein kinase par-1

Gene

par-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157ATPPROSITE-ProRule annotationBy similarity1
Active sitei250Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 142ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase par-1By similarityImported (EC:2.7.11.1)
Gene namesi
Name:par-1
ORF Names:CBG04756
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome V, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG04756a ; CBP47106 ; WBGene00027371 ; Cbr-par-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003833211 – 1088Serine/threonine-protein kinase par-1Add BLAST1088

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG04756

Structurei

3D structure databases

ProteinModelPortaliA8WYE4
SMRiA8WYE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 379Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini398 – 440UBAPROSITE-ProRule annotationAdd BLAST43
Domaini1039 – 1088KA1PROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 114Ser-richSequence analysisAdd BLAST113
Compositional biasi736 – 829Ser-richSequence analysisAdd BLAST94

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
HOGENOMiHOG000233025
InParanoidiA8WYE4
KOiK08798
OMAiLPRCRNS
OrthoDBiEOG091G0D1E

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PANTHERiPTHR24346 PTHR24346, 3 hits
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

A8WYE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVSSYFMG ISSKKNGSSA TANKQSTRPQ ESHHHRRQQP TSQQSTEMNG
60 70 80 90 100
TTTAPSGGTS SGTTTTSSGV PTASTGGGSA RYSSSSSGRS HPTTGGGSSS
110 120 130 140 150
HARSSGQSGM SSRSAARRND QDVHVGKYKL LKTIGKGNFA KVKLAKHVIT
160 170 180 190 200
GHEVAIKIID KTALNPSSLQ KLFREVKIMK QLDHPNIVKL YQVMETEQTL
210 220 230 240 250
YLVLEYASGG EVFDYLVAHG RMKEKEARAK FRQIVSAVQY LHSKNIIHRD
260 270 280 290 300
LKAENLLLDQ DMNIKIADFG FSNTFSLGNK LDTFCGSPPY AAPELFSGKK
310 320 330 340 350
YDGPEVDVWS LGVILYTLVS GSLPFDGQNL KELRERVLRG KYRIPFYMST
360 370 380 390 400
DCENLLKKFL VINPQRRSSL DNIMKDRWMN VGYEDDELKP FIEPPKDQID
410 420 430 440 450
EQRIEKLIQI FQLGFNKATI LESVEKEKFE DIHATYLLLG ERKSDPSRYS
460 470 480 490 500
RSSATATGPS ITSGAALASA ANAQKHQSSA APASGSSSSR RSSQNDAAAS
510 520 530 540 550
GAGGTVVMSG TRHGGVQMRA QPTSRQAAIS LLQPPSYKPS SNTTQIAQIP
560 570 580 590 600
PLFNRNSTAT SSTNQPSSGI TAGTRKIDPK GRIPLNSAAV QSHRTATGAV
610 620 630 640 650
AANTGGIPSQ RDHSQQQQQY MNQLTSSSMM SKLINKTPAA GGANATTSAT
660 670 680 690 700
SAAAAPLQKS GSQISHAPTE PVIREDDDES NSEHQNGNVP LIGGVGPQTS
710 720 730 740 750
PVVAPSEDVT SSEQQKQEKA SSEAPKETKP SMIHQSPSMP PSQMMTAMES
760 770 780 790 800
LKLSESGGKS PSNSQQPPQR ATSQQMSRSA TTNSAANMAS NQQSSGAPQQ
810 820 830 840 850
SGASSQQCHT KPSSTSSSSS SSTTAPTSSG QPHHQHQLTH NASFSVTPSA
860 870 880 890 900
YQMPTTTTIT SGAPTSSSAF PRNTRNRQTF HGKTEKDKGG DDGSDEIGDT
910 920 930 940 950
PANVSIGATG ASANNTEGTI WSKLSKLTRR DHNRESMTQP VSSRAGTIGA
960 970 980 990 1000
AQGQQTAAAL AAIREQSSGP LTPGTPPVAQ AMTQEGDVKP RSLRFTWSMK
1010 1020 1030 1040 1050
TTSSLAPDDM MREIRKVLDA NGCDYEQRER YMILCVHGDP NTDSLVQWEM
1060 1070 1080
EVCKLPRLSL NGVRFKRISG TSIGFKNIAS KIAQELNL
Length:1,088
Mass (Da):116,525
Last modified:January 15, 2008 - v1
Checksum:i805A332FC0C22850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601135 Genomic DNA Translation: CAP25402.1
RefSeqiXP_002637943.1, XM_002637897.1

Genome annotation databases

GeneIDi8579940
KEGGicbr:CBG04756

Similar proteinsi

Entry informationi

Entry nameiPAR1_CAEBR
AccessioniPrimary (citable) accession number: A8WYE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: January 15, 2008
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome