A8WWX1 (MOM4_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitogen-activated protein kinase kinase kinase mom-4
EC=2.7.11.25

Gene names

Name:	mom-4
ORF Names:	CBG03852

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 By similarity. UniProtKB Q9XTC6
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB O43318
Cofactor	Magnesium By similarity. UniProtKB O43318
Subunit structure	Interacts with, and is activated by, tap-1 By similarity. UniProtKB Q9XTC6
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. UniProtKB O43318 Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase kinase kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	Mitogen-activated protein kinase kinase kinase mom-4		PRO_0000351144
Regions
	Domain	53 – 308	256	Protein kinase
	Nucleotide binding	59 – 67	9	ATP By similarity UniProtKB O43318
	Compositional bias	10 – 22	13	Poly-Ser
Sites
	Active site	178	1	Proton acceptor By similarity UniProtKB O43318
	Binding site	86	1	ATP By similarity UniProtKB O43318

Sequences

	Sequence		Length	Mass (Da)
	A8WWX1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: AA27D2EE4637E5CF	FASTA	545	61,858
	10 20 30 40 50 60 MDTSPHSKPS SSSASQSSHS PSPAPVTAPR KTRDSGLCMT QDIPEIPTHC IDNLNSHQLG 70 80 90 100 110 120 RGTYGIVEKT RYRRSRNHEY RPAAIKYSSP IHLATLIREA KVMWALRDHS NIIKIYGLYR 130 140 150 160 170 180 DARHGQGVVM EYMDCGSMSE LIYDRKSIDY TIDHVASWLY QMASAVNTFH RNDQVHRDLK 190 200 210 220 230 240 LQNMLLCDRY RTMKLCDFGT FTAMHQSMTS NRGTPITMAP EVFRCEEYNQ KSDIYSIGII 250 260 270 280 290 300 MWQMIARNHP YNRNLSVPGL LYNVATASLR PPELDCNPIL SDFYKQCWHD DPVSRPTAAE 310 320 330 340 350 360 CLQYFTALKT EYPNGNVPLA DANTNRPVET PPPRVHRPSG LGSASGSGLG TNGRTPTASN 370 380 390 400 410 420 HLNAPQAVNT HRRNRSETIQ MKPELPYPVM PGEVAASSSG AFRGPRSQSE AKNLRDAGRS 430 440 450 460 470 480 QSGQRHPHRN APPIPIDDRR DSNESNEKDA IFMELLRNDD TRPVDPDARD EASLDIFHQH 490 500 510 520 530 540 CSSNKEYADA LLLKKEVLRA KHELLSRWPQ HQRHVELLER QNYLEQEIAK LEYNSDDDFS ITERL

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000457 Genomic DNA. Translation: CAP24673.1.
RefSeq	XP_002639286.1. XM_002639240.1.
3D structure databases
ProteinModelPortal	A8WWX1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8581279.
KEGG	cbr:CBG03852.
Organism-specific databases
CTD	8581279.
WormBase	CBG03852; CBP06575; WBGene00026627.
Phylogenomic databases
HOGENOM	HBG379074.
OMA	IDHVASW.
PhylomeDB	A8WWX1.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR001245. Ser-Thr/Tyr_kinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOM4_CAEBR

Accession

Primary (citable) accession number: A8WWX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project