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A8WVU7

- CPG1_CAEBR

UniProt

A8WVU7 - CPG1_CAEBR

Protein

Chondroitin proteoglycan 1

Gene

cpg-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin By similarity.By similarity

    GO - Molecular functioni

    1. chitin binding Source: UniProtKB

    GO - Biological processi

    1. chitin metabolic process Source: InterPro
    2. embryo development Source: UniProtKB
    3. mitotic cytokinesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    Chitin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondroitin proteoglycan 1
    Alternative name(s):
    Cell junction protein 1
    Cytokinesis protein cej-1
    Gene namesi
    Name:cpg-1
    ORF Names:CBG03957
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG03957; CBP06611; WBGene00026714; Cbr-cpg-1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 686668Chondroitin proteoglycan 1PRO_0000320219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 109PROSITE-ProRule annotation
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi261 ↔ 274PROSITE-ProRule annotation
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG03957.

    Structurei

    3D structure databases

    ProteinModelPortaliA8WVU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 12058Chitin-binding type-2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini228 – 28558Chitin-binding type-2 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi316 – 592277Thr-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 2 chitin-binding type-2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG259424.
    HOGENOMiHOG000111921.
    OMAiTTVGYEP.
    OrthoDBiEOG7SR4NG.

    Family and domain databases

    Gene3Di2.170.140.10. 2 hits.
    InterProiIPR002557. Chitin-bd_dom.
    [Graphical view]
    PfamiPF01607. CBM_14. 2 hits.
    [Graphical view]
    SMARTiSM00494. ChtBD2. 2 hits.
    [Graphical view]
    SUPFAMiSSF57625. SSF57625. 2 hits.
    PROSITEiPS50940. CHIT_BIND_II. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8WVU7-1 [UniParc]FASTAAdd to Basket

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    MLPKSVLIVA FLVASSSAQY GVTGMYENLP LESTTVEASG EGSGYNESND    50
    DGFVTGADAV AIDTDCSTKE DGLYAIGGCS PQFLTCSGGI ARIMDCPANL 100
    IYDQRIIACE YSYNVPECSG VPQDVSSTQA YYPATEETTP AENVTVPAET 150
    TVDPYAPVEV ATTAAPSEDV PVETTASPYA PVEVETTTAP AEDVTVPEET 200
    TVAPYAPVEV YTTAAPANDE PVTRTLLDKT CNGKADGFYS FGQCSDHYIA 250
    CSNGYTIPMQ CPARLSFDEA RVICDYTMNV PECQNGSGNY EGSAEETTTE 300
    ASGELPYSNG YGYEETTTAA ADVPSTEGYA PETTAEAWVA PYRLESTTAA 350
    DVPTTTVGYA PEVIEETTTS EYVEETTTAA DVSTTTTVEY VPEVTETTTA 400
    PYVEETTTAE YVEETTTAAD VPTTTTVAYA PEVTETTTVP YIEETTTVEE 450
    ATTAADVPTT TGYVPEVIET TTTPYVEETT TAEYVEETST AADVPTTTTV 500
    AYAPEVTETT TVPYIEETTT VEEATTAADV PTTTGYVPEV IETTTTPYVE 550
    ETTTVEETTT TTVAYAPEVV ETTTTPYVEE STTTPYVEET TTALMFHPPQ 600
    SKATKLPQIH HPASKEHLLS SHAHKTIETV SMDMNLSSSA SRDSSSLQSK 650
    DDAQLLTKLR SATNRTSTKE ATTRTQNMHA HYHRNH 686
    Length:686
    Mass (Da):73,321
    Last modified:January 15, 2008 - v1
    Checksum:i6C43466951D120A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600906 Genomic DNA. Translation: CAP24760.1.
    RefSeqiXP_002639373.1. XM_002639327.1.

    Genome annotation databases

    EnsemblMetazoaiCBG03957; CBG03957; CBG03957.
    GeneIDi8581366.
    KEGGicbr:CBG03957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600906 Genomic DNA. Translation: CAP24760.1 .
    RefSeqi XP_002639373.1. XM_002639327.1.

    3D structure databases

    ProteinModelPortali A8WVU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG03957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG03957 ; CBG03957 ; CBG03957 .
    GeneIDi 8581366.
    KEGGi cbr:CBG03957.

    Organism-specific databases

    CTDi 8581366.
    WormBasei CBG03957 ; CBP06611 ; WBGene00026714 ; Cbr-cpg-1.

    Phylogenomic databases

    eggNOGi NOG259424.
    HOGENOMi HOG000111921.
    OMAi TTVGYEP.
    OrthoDBi EOG7SR4NG.

    Family and domain databases

    Gene3Di 2.170.140.10. 2 hits.
    InterProi IPR002557. Chitin-bd_dom.
    [Graphical view ]
    Pfami PF01607. CBM_14. 2 hits.
    [Graphical view ]
    SMARTi SM00494. ChtBD2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57625. SSF57625. 2 hits.
    PROSITEi PS50940. CHIT_BIND_II. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiCPG1_CAEBR
    AccessioniPrimary (citable) accession number: A8WVU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3