ID   A8WUI7_CAEBR            Unreviewed;      1129 AA.
AC   A8WUI7;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Protein CBR-DSH-1 {ECO:0000313|EMBL:CAP24149.2};
GN   Name=dsh-1 {ECO:0000313|WormBase:CBG02352a};
GN   Synonyms=Cbr-dsh-1 {ECO:0000313|EMBL:CAP24149.2};
GN   ORFNames=CBG02352 {ECO:0000313|WormBase:CBG02352a}, CBG_02352
GN   {ECO:0000313|EMBL:CAP24149.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP24149.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP24149.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP24149.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE601438; CAP24149.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WUI7; -.
DR   STRING; 6238.A8WUI7; -.
DR   WormBase; CBG02352a; CBP45455; WBGene00025421; Cbr-dsh-1.
DR   eggNOG; KOG3571; Eukaryota.
DR   HOGENOM; CLU_013997_0_0_1; -.
DR   InParanoid; A8WUI7; -.
DR   OMA; DGESRMY; -.
DR   OrthoDB; 2910598at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04438; DEP_dishevelled; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.240.130; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008339; Dishevelled_fam.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR038207; DIX_dom_sf.
DR   InterPro; IPR015506; Dsh/Dvl-rel.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10878:SF40; DISHEVELLED RELATED; 1.
DR   PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00778; DIX; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   PRINTS; PR01760; DISHEVELLED.
DR   SMART; SM00021; DAX; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50841; DIX; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW   ProRule:PRU00069}.
FT   DOMAIN          64..146
FT                   /note="DIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50841"
FT   DOMAIN          801..874
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          988..1062
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          659..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        735..754
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..780
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1129 AA;  123937 MW;  3A3D3E0FD146019E CRC64;
     MAESPPRVDS SAPDVGDPTS MMERLRLGDD GGKDDEFDNK SVSSAQYSQA SEATTAVKQQ
     PFLHTMTKVY CHIDDETDPY MLEVHVPPDL ITLGDLKRVL MRTNFKYYRK ALDPDSGYEV
     KAEIRDDSQR LTPSSNNLFE LFLLTIEGST HSDGSSGKMR KYPSVPGPAP SNRSGPPMNY
     QHAAYQFDNS MMSTDSESMI SAAIPGYLKS AAYNRRFPQH YLAMSIKLGV ARERAIPASS
     NTPSTSSMTT SSDVLRSLLF TAKERKVLST YTAPPSHRNH SPGVVSQLIN KIEQKASPPT
     TSSRTKKKKK APPLAQIDDL DLIEDEKTVV EVAKSPRRKK YTGNPLGNLK ILNGFLPSSK
     TTDDKENDSV PSTGKKLKKS KSKSRVEPET DPPFRLKRTL TDLTNNHTPS GSTWRQMVSN
     ALGGPLKKRL SEGALFFPGT SKAADDCVDE EGGNTKTKTK SPFLQRRKQN EKSAGGANRK
     ESGGSASSSF FGALIRLSHS AASLTSLTSL GGSRSNSASP SSSRSNTKEF KEELKPPQPP
     PPDLISPAAA LSKPIFSLAP PSSPVSLTPP SRELRKSKTC QITTDRPPII PSITISESRS
     LNRIDRCRPV TVDGSNLTPD RRPLVSRRST MSRTMSLIPT SPSLPPLYEE EMASTAAMVD
     EEREEKTQKR RMRRYGGSNT TSTYQGRKDA APDASPRRHL IGFLHRTSHL SLTSELSADA
     SFYLIGHRRH LEESTIGSES DARVFSDDDD RGSTTTDFTS VSRQHEKMAK KKKNKRNFRK
     PSRASSFSSI TESSMSLDVI TVNLNMDTVN FLGISIVGQT SNCGDNGIYV ANIMKGGAVA
     LDGRIEAGDM ILQVNETSFE NFTNDQAVDV LREAVSRRGP IKLTVAKSFE NGQSCFTIPR
     NSREEPVRPI DTQAWIQHTN AMRGMPSIVE ESAPTPIPGE WPHGRPPSSS TVTSNGSNGQ
     NTVVGNGAHI HLDIHTDKKK VVEIMAMPGS GLDIKNRTWL KIPIPMSFLG SDLVEWLLDR
     IEGLRERKTA RNYAADLLKL KYIAHVVNKV TFTEQCYYVL GDECADYARF RNEDGGPKYQ
     WTMGMNGMSA GNGSSVMLPP PQFPGAVPFK GMAPSMVSDG ESRMYVMHI
//