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A8WTA7

- TRMB_CAEBR

UniProt

A8WTA7 - TRMB_CAEBR

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

CBG02883

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei152 – 1521S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei155 – 1551UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:CBG02883
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG02883; CBP00870; WBGene00025851.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256tRNA (guanine-N(7)-)-methyltransferasePRO_0000370563Add
BLAST

Proteomic databases

PRIDEiA8WTA7.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG02883.

Structurei

3D structure databases

ProteinModelPortaliA8WTA7.
SMRiA8WTA7. Positions 46-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 982S-adenosyl-L-methionine bindingUniRule annotation
Regioni132 – 1332S-adenosyl-L-methionine bindingUniRule annotation
Regioni230 – 2323S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000260965.
InParanoidiA8WTA7.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8WTA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVDPVNSEM ELDNKPTCET VPGLPQKKHY RQRAHSNPHS DHDIEYPLTP
60 70 80 90 100
DHMDWSKQYG DYAAGRQVEF ADIGCGYGGL LMRLSPMFPE TLMIGMEIRV
110 120 130 140 150
KVSDYVNEKI QALRKHHEGA GHYRNIAVLR SNAMKYMPNY FRKGQLSKMF
160 170 180 190 200
FLFPDPHFKN KKHKWRIITP TLVSEYAYVL REQGLIYTIT DVKDLHDWMV
210 220 230 240 250
KHLNEHPLFE RLSDDEMKAD PVVAMLYEST EEGQKVTRND GEKWPAVFRR

LPNPPL
Length:256
Mass (Da):29,917
Last modified:January 15, 2008 - v1
Checksum:i45BBC098C8F2C376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601438 Genomic DNA. Translation: CAP23718.1.
RefSeqiXP_002631108.1. XM_002631062.1.

Genome annotation databases

EnsemblMetazoaiCBG02883; CBG02883; CBG02883.
GeneIDi8572622.
KEGGicbr:CBG02883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601438 Genomic DNA. Translation: CAP23718.1 .
RefSeqi XP_002631108.1. XM_002631062.1.

3D structure databases

ProteinModelPortali A8WTA7.
SMRi A8WTA7. Positions 46-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG02883.

Proteomic databases

PRIDEi A8WTA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG02883 ; CBG02883 ; CBG02883 .
GeneIDi 8572622.
KEGGi cbr:CBG02883.

Organism-specific databases

CTDi 8572622.
WormBasei CBG02883 ; CBP00870 ; WBGene00025851 .

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000260965.
InParanoidi A8WTA7.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiTRMB_CAEBR
AccessioniPrimary (citable) accession number: A8WTA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3