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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene

tps-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.By similarity

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene namesi
Name:tps-1
ORF Names:CBG01861
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG01861a ; CBP40035 ; WBGene00025041 ; Cbr-tps-1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851751 – 1374Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1Add BLAST1374

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG01861

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1050 Eukaryota
COG0380 LUCA
HOGENOMiHOG000016516
InParanoidiA8WRG3
OMAiGREWYLN
OrthoDBiEOG091G00R4

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit

Sequencei

Sequence statusi: Complete.

A8WRG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQLQKSMS DGMATTAAAV PMNANGVDTG KVPTAPPDVF FSTENEPEDC
60 70 80 90 100
TPVKMDPFDR PKSDKDPVED AIERLLKVME KIDCPYTPGK EKGVDQDESD
110 120 130 140 150
DMTESEDHDE MAKDDEGIPA NEVRVETRKM DCTTGQLVAP RIYEKVDTLS
160 170 180 190 200
STSESSAEED ESMMIIKEGI RVCYGVWKKR QKNSEMALKG LAIVLELCLT
210 220 230 240 250
QPSARDEIFS VLLETLGFNT VTYWKAVVPQ VVDSDLTYAT QYREALLFSM
260 270 280 290 300
CLYDVNHSKN RLRELYAAIP GFRQSMLGIR AKQFTERYRH LQMKIARSRQ
310 320 330 340 350
SSRMSSKYGS EDNIQAMVTL ANDVIMDEET APTQMPLVDM SHDKQRVINV
360 370 380 390 400
SNAPPVSISR KTSGSWEIKQ GSGGLVACVD PVMSADKKNI WLSNLGVNMQ
410 420 430 440 450
EELKEHSTTT NSIGLPLIKQ ACAGEVFCVL ERNEKKELTP KQQAVESDMS
460 470 480 490 500
LLSVLNTYNK HSYQLNPVVV NQDDYDTYYG GISNGLLWPA LHNLPQFISP
510 520 530 540 550
CYNDPEALRE QWCAYVRVNY LFSINAARNS RAQDFIWIHD YHLMLCGQIM
560 570 580 590 600
RSLEGSLDVS SIEEREGKQK ESLQIGFFLH IPFQPPANFM TKYRTVGEPI
610 620 630 640 650
VRALLRFTKV GFQTSRDRET FVKLVADHIK RTKIDYDSRL DRYTIEHDGF
660 670 680 690 700
ACSLGVFPVS IKIADFVNIA KNPQTVIEAE EIRKQIMGKC ADGGQLFFSV
710 720 730 740 750
ERFDYTKGIA EKLRAWQRYF EKYPDRIGKD VLFQVAVTNR RSVESYRQYQ
760 770 780 790 800
DDVMALAELI NQKFHSEQYP EWKPVIFETD GLPRSRLIAH YLAMDIGVVT
810 820 830 840 850
PSKDGMNLVA KEMLVCNPTA SLVLSTGAGT EVQLSNAQFY SEQEGKCYHR
860 870 880 890 900
VEDIANTEAF ADNFFAAATE SKETRNKHGE KINQFLCVHD IDEWSDQFLD
910 920 930 940 950
PKWTHEVISE CEVKQLGQFY GLMNRTAQVR RQIVECVLKG LPIRPHFKFS
960 970 980 990 1000
LENAKVTRQA NDSECTTLTS LETSCPEGTS KLTLEADEES GEEKGFKITY
1010 1020 1030 1040 1050
DIHDELSEME KDLAFLSFIQ SDEYENAEEF IKTIGSFYEG GPILFSEEVK
1060 1070 1080 1090 1100
QAAEMLQRGI HYNTFFTDRD GTLKSYACSY PTSVQPAYSA VIQAQFARRC
1110 1120 1130 1140 1150
ATFCAIVTTA PLIHTGILEV ATIPEGYYAY GASAGREWYL NPAQQFKDRS
1160 1170 1180 1190 1200
FSAVDLTLMN KVFELIEELL EKPEFRTFKW IGSGIQKHCG HITIAKQDVN
1210 1220 1230 1240 1250
GTIPARKVTR LHEQLVKIVN DFDPTGTTLT MRESDLDFKI YVKAKLKGRI
1260 1270 1280 1290 1300
FNKGHGIRLV KERLKPNMSK GSCLVCGDSE SDIPMLEECL KLAGSKVYTI
1310 1320 1330 1340 1350
WVTRDQALQE KVSQLCERYS CTNIHYVTCP QVLLGAMAYA TAHTLTNEKN
1360 1370
RKADSYYDDS DTPMDQEDTP SKQQ
Length:1,374
Mass (Da):155,650
Last modified:December 16, 2008 - v2
Checksum:i9409B98090517A87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601451 Genomic DNA Translation: CAP23071.2

Similar proteinsi

Entry informationi

Entry nameiTPS1_CAEBR
AccessioniPrimary (citable) accession number: A8WRG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health