A8WRG3 (TPS1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1

Gene names

Name:	tps-1
ORF Names:	CBG01861

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.
Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Sequence similarities	In the N-terminal section; belongs to the glycosyltransferase 20 family. In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1374	1374	Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1		PRO_0000385175

Sequences

	Sequence		Length	Mass (Da)
	A8WRG3 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 9409B98090517A87	FASTA	1,374	155,650
	10 20 30 40 50 60 MVQQLQKSMS DGMATTAAAV PMNANGVDTG KVPTAPPDVF FSTENEPEDC TPVKMDPFDR 70 80 90 100 110 120 PKSDKDPVED AIERLLKVME KIDCPYTPGK EKGVDQDESD DMTESEDHDE MAKDDEGIPA 130 140 150 160 170 180 NEVRVETRKM DCTTGQLVAP RIYEKVDTLS STSESSAEED ESMMIIKEGI RVCYGVWKKR 190 200 210 220 230 240 QKNSEMALKG LAIVLELCLT QPSARDEIFS VLLETLGFNT VTYWKAVVPQ VVDSDLTYAT 250 260 270 280 290 300 QYREALLFSM CLYDVNHSKN RLRELYAAIP GFRQSMLGIR AKQFTERYRH LQMKIARSRQ 310 320 330 340 350 360 SSRMSSKYGS EDNIQAMVTL ANDVIMDEET APTQMPLVDM SHDKQRVINV SNAPPVSISR 370 380 390 400 410 420 KTSGSWEIKQ GSGGLVACVD PVMSADKKNI WLSNLGVNMQ EELKEHSTTT NSIGLPLIKQ 430 440 450 460 470 480 ACAGEVFCVL ERNEKKELTP KQQAVESDMS LLSVLNTYNK HSYQLNPVVV NQDDYDTYYG 490 500 510 520 530 540 GISNGLLWPA LHNLPQFISP CYNDPEALRE QWCAYVRVNY LFSINAARNS RAQDFIWIHD 550 560 570 580 590 600 YHLMLCGQIM RSLEGSLDVS SIEEREGKQK ESLQIGFFLH IPFQPPANFM TKYRTVGEPI 610 620 630 640 650 660 VRALLRFTKV GFQTSRDRET FVKLVADHIK RTKIDYDSRL DRYTIEHDGF ACSLGVFPVS 670 680 690 700 710 720 IKIADFVNIA KNPQTVIEAE EIRKQIMGKC ADGGQLFFSV ERFDYTKGIA EKLRAWQRYF 730 740 750 760 770 780 EKYPDRIGKD VLFQVAVTNR RSVESYRQYQ DDVMALAELI NQKFHSEQYP EWKPVIFETD 790 800 810 820 830 840 GLPRSRLIAH YLAMDIGVVT PSKDGMNLVA KEMLVCNPTA SLVLSTGAGT EVQLSNAQFY 850 860 870 880 890 900 SEQEGKCYHR VEDIANTEAF ADNFFAAATE SKETRNKHGE KINQFLCVHD IDEWSDQFLD 910 920 930 940 950 960 PKWTHEVISE CEVKQLGQFY GLMNRTAQVR RQIVECVLKG LPIRPHFKFS LENAKVTRQA 970 980 990 1000 1010 1020 NDSECTTLTS LETSCPEGTS KLTLEADEES GEEKGFKITY DIHDELSEME KDLAFLSFIQ 1030 1040 1050 1060 1070 1080 SDEYENAEEF IKTIGSFYEG GPILFSEEVK QAAEMLQRGI HYNTFFTDRD GTLKSYACSY 1090 1100 1110 1120 1130 1140 PTSVQPAYSA VIQAQFARRC ATFCAIVTTA PLIHTGILEV ATIPEGYYAY GASAGREWYL 1150 1160 1170 1180 1190 1200 NPAQQFKDRS FSAVDLTLMN KVFELIEELL EKPEFRTFKW IGSGIQKHCG HITIAKQDVN 1210 1220 1230 1240 1250 1260 GTIPARKVTR LHEQLVKIVN DFDPTGTTLT MRESDLDFKI YVKAKLKGRI FNKGHGIRLV 1270 1280 1290 1300 1310 1320 KERLKPNMSK GSCLVCGDSE SDIPMLEECL KLAGSKVYTI WVTRDQALQE KVSQLCERYS 1330 1340 1350 1360 1370 CTNIHYVTCP QVLLGAMAYA TAHTLTNEKN RKADSYYDDS DTPMDQEDTP SKQQ

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE601451 Genomic DNA. Translation: CAP23071.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG01861; CBG01861; CBG01861.
Organism-specific databases
WormBase	CBG01861; CBP36949; WBGene00025041; Cbr-tps-1.
Phylogenomic databases
eggNOG	COG0380.
HOGENOM	HOG000016516.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR023214. HAD-like_dom. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPS1_CAEBR

Accession

Primary (citable) accession number: A8WRG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	December 16, 2008
Last modified:	March 6, 2013
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project