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A8WRG3 (TPS1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene names
Name:tps-1
ORF Names:CBG01861
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process By similarity.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 20 family.

In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13741374Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
PRO_0000385175

Sequences

Sequence LengthMass (Da)Tools
A8WRG3 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 9409B98090517A87

FASTA1,374155,650
        10         20         30         40         50         60 
MVQQLQKSMS DGMATTAAAV PMNANGVDTG KVPTAPPDVF FSTENEPEDC TPVKMDPFDR 

        70         80         90        100        110        120 
PKSDKDPVED AIERLLKVME KIDCPYTPGK EKGVDQDESD DMTESEDHDE MAKDDEGIPA 

       130        140        150        160        170        180 
NEVRVETRKM DCTTGQLVAP RIYEKVDTLS STSESSAEED ESMMIIKEGI RVCYGVWKKR 

       190        200        210        220        230        240 
QKNSEMALKG LAIVLELCLT QPSARDEIFS VLLETLGFNT VTYWKAVVPQ VVDSDLTYAT 

       250        260        270        280        290        300 
QYREALLFSM CLYDVNHSKN RLRELYAAIP GFRQSMLGIR AKQFTERYRH LQMKIARSRQ 

       310        320        330        340        350        360 
SSRMSSKYGS EDNIQAMVTL ANDVIMDEET APTQMPLVDM SHDKQRVINV SNAPPVSISR 

       370        380        390        400        410        420 
KTSGSWEIKQ GSGGLVACVD PVMSADKKNI WLSNLGVNMQ EELKEHSTTT NSIGLPLIKQ 

       430        440        450        460        470        480 
ACAGEVFCVL ERNEKKELTP KQQAVESDMS LLSVLNTYNK HSYQLNPVVV NQDDYDTYYG 

       490        500        510        520        530        540 
GISNGLLWPA LHNLPQFISP CYNDPEALRE QWCAYVRVNY LFSINAARNS RAQDFIWIHD 

       550        560        570        580        590        600 
YHLMLCGQIM RSLEGSLDVS SIEEREGKQK ESLQIGFFLH IPFQPPANFM TKYRTVGEPI 

       610        620        630        640        650        660 
VRALLRFTKV GFQTSRDRET FVKLVADHIK RTKIDYDSRL DRYTIEHDGF ACSLGVFPVS 

       670        680        690        700        710        720 
IKIADFVNIA KNPQTVIEAE EIRKQIMGKC ADGGQLFFSV ERFDYTKGIA EKLRAWQRYF 

       730        740        750        760        770        780 
EKYPDRIGKD VLFQVAVTNR RSVESYRQYQ DDVMALAELI NQKFHSEQYP EWKPVIFETD 

       790        800        810        820        830        840 
GLPRSRLIAH YLAMDIGVVT PSKDGMNLVA KEMLVCNPTA SLVLSTGAGT EVQLSNAQFY 

       850        860        870        880        890        900 
SEQEGKCYHR VEDIANTEAF ADNFFAAATE SKETRNKHGE KINQFLCVHD IDEWSDQFLD 

       910        920        930        940        950        960 
PKWTHEVISE CEVKQLGQFY GLMNRTAQVR RQIVECVLKG LPIRPHFKFS LENAKVTRQA 

       970        980        990       1000       1010       1020 
NDSECTTLTS LETSCPEGTS KLTLEADEES GEEKGFKITY DIHDELSEME KDLAFLSFIQ 

      1030       1040       1050       1060       1070       1080 
SDEYENAEEF IKTIGSFYEG GPILFSEEVK QAAEMLQRGI HYNTFFTDRD GTLKSYACSY 

      1090       1100       1110       1120       1130       1140 
PTSVQPAYSA VIQAQFARRC ATFCAIVTTA PLIHTGILEV ATIPEGYYAY GASAGREWYL 

      1150       1160       1170       1180       1190       1200 
NPAQQFKDRS FSAVDLTLMN KVFELIEELL EKPEFRTFKW IGSGIQKHCG HITIAKQDVN 

      1210       1220       1230       1240       1250       1260 
GTIPARKVTR LHEQLVKIVN DFDPTGTTLT MRESDLDFKI YVKAKLKGRI FNKGHGIRLV 

      1270       1280       1290       1300       1310       1320 
KERLKPNMSK GSCLVCGDSE SDIPMLEECL KLAGSKVYTI WVTRDQALQE KVSQLCERYS 

      1330       1340       1350       1360       1370 
CTNIHYVTCP QVLLGAMAYA TAHTLTNEKN RKADSYYDDS DTPMDQEDTP SKQQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601451 Genomic DNA. Translation: CAP23071.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG01861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG01861; CBG01861; CBG01861.

Organism-specific databases

WormBaseCBG01861; CBP36949; WBGene00025041; Cbr-tps-1.

Phylogenomic databases

eggNOGCOG0380.
HOGENOMHOG000016516.
OrthoDBEOG7P2XRB.

Family and domain databases

InterProIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPS1_CAEBR
AccessionPrimary (citable) accession number: A8WRG3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families