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A8WPF0 (SDHB_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhb-1
ORF Names:CBG00872
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. UniProtKB Q9YHT2

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity. UniProtKB Q9YHT2

Binds 1 3Fe-4S cluster By similarity. UniProtKB Q9YHT2

Binds 1 4Fe-4S cluster By similarity. UniProtKB Q9YHT2

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity. UniProtKB Q9YHT2

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity UniProtKB Q9YHT2.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000367044

Regions

Domain43 – 131892Fe-2S ferredoxin-type
Domain174 – 204314Fe-4S ferredoxin-type
Compositional bias25 – 284Poly-Ala

Sites

Metal binding911Iron-sulfur 1 (2Fe-2S) By similarity UniProtKB Q9YHT2
Metal binding961Iron-sulfur 1 (2Fe-2S) By similarity UniProtKB Q9YHT2
Metal binding991Iron-sulfur 1 (2Fe-2S) By similarity UniProtKB Q9YHT2
Metal binding1111Iron-sulfur 1 (2Fe-2S) By similarity UniProtKB Q9YHT2
Metal binding1841Iron-sulfur 2 (4Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding1871Iron-sulfur 2 (4Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding1901Iron-sulfur 2 (4Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding1941Iron-sulfur 3 (3Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding2411Iron-sulfur 3 (3Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding2471Iron-sulfur 3 (3Fe-4S) By similarity UniProtKB Q9YHT2
Metal binding2511Iron-sulfur 2 (4Fe-4S) By similarity UniProtKB Q9YHT2
Binding site1991Ubiquinone; shared with DHSD By similarity UniProtKB Q9YHT2

Sequences

Sequence LengthMass (Da)Tools
A8WPF0 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 9A82F1BE0D05E8A1

FASTA28231,343
        10         20         30         40         50         60 
MLARSALFVH SAELAANAAR AASGAAAAQP KKTGNRIKTF EIYRFNPEAP GAKPTIQKFD 

        70         80         90        100        110        120 
VDLDQCGTMI LDALIKIKNE VDPTLTFRRS CREGICGSCA MNIGGENTLA CICKIDADTS 

       130        140        150        160        170        180 
KSTKIYPLPH MFVVKDLVPD MNLFYAQYAS IQPWIQKKTP LTLGEKQMHQ SVAERDRLDG 

       190        200        210        220        230        240 
LYECILCACC STSCPSYWWN ADKYLGPAVL MQAYRWVIDS RDDYAQERLH RMHDSFSAFK 

       250        260        270        280 
CHTIMNCTKT CPKHLNPAKA IGEIKSLLTG FKSKPAAEPS AF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600951 Genomic DNA. Translation: CAP22357.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG00872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG00872; CBG00872; CBG00872.

Organism-specific databases

WormBaseCBG00872; CBP34424; WBGene00024197; Cbr-sdhb-1.

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
OrthoDBEOG7H4DTN.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_CAEBR
AccessionPrimary (citable) accession number: A8WPF0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways