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A8WPF0

- SDHB_CAEBR

UniProt

A8WPF0 - SDHB_CAEBR

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Protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene
sdhb-1, CBG00872
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.By similarity
Binds 1 3Fe-4S cluster By similarity.By similarity
Binds 1 4Fe-4S cluster By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Iron-sulfur 1 (2Fe-2S) By similarityBy similarity
Metal bindingi96 – 961Iron-sulfur 1 (2Fe-2S) By similarityBy similarity
Metal bindingi99 – 991Iron-sulfur 1 (2Fe-2S) By similarityBy similarity
Metal bindingi111 – 1111Iron-sulfur 1 (2Fe-2S) By similarityBy similarity
Metal bindingi184 – 1841Iron-sulfur 2 (4Fe-4S) By similarityBy similarity
Metal bindingi187 – 1871Iron-sulfur 2 (4Fe-4S) By similarityBy similarity
Metal bindingi190 – 1901Iron-sulfur 2 (4Fe-4S) By similarityBy similarity
Metal bindingi194 – 1941Iron-sulfur 3 (3Fe-4S) By similarityBy similarity
Binding sitei199 – 1991Ubiquinone; shared with DHSD By similarityBy similarity
Metal bindingi241 – 2411Iron-sulfur 3 (3Fe-4S) By similarityBy similarity
Metal bindingi247 – 2471Iron-sulfur 3 (3Fe-4S) By similarityBy similarity
Metal bindingi251 – 2511Iron-sulfur 2 (4Fe-4S) By similarityBy similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  7. ubiquinone binding Source: UniProtKB

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdhb-1
ORF Names:CBG00872
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG00872; CBP34424; WBGene00024197; Cbr-sdhb-1.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex II Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000367044
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.By similarity

Protein-protein interaction databases

STRINGi6238.CBG00872.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 131892Fe-2S ferredoxin-type
Add
BLAST
Domaini174 – 204314Fe-4S ferredoxin-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 284Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
OrthoDBiEOG7H4DTN.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8WPF0-1 [UniParc]FASTAAdd to Basket

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MLARSALFVH SAELAANAAR AASGAAAAQP KKTGNRIKTF EIYRFNPEAP    50
GAKPTIQKFD VDLDQCGTMI LDALIKIKNE VDPTLTFRRS CREGICGSCA 100
MNIGGENTLA CICKIDADTS KSTKIYPLPH MFVVKDLVPD MNLFYAQYAS 150
IQPWIQKKTP LTLGEKQMHQ SVAERDRLDG LYECILCACC STSCPSYWWN 200
ADKYLGPAVL MQAYRWVIDS RDDYAQERLH RMHDSFSAFK CHTIMNCTKT 250
CPKHLNPAKA IGEIKSLLTG FKSKPAAEPS AF 282
Length:282
Mass (Da):31,343
Last modified:December 16, 2008 - v2
Checksum:i9A82F1BE0D05E8A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22357.2.

Genome annotation databases

EnsemblMetazoaiCBG00872; CBG00872; CBG00872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22357.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG00872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG00872 ; CBG00872 ; CBG00872 .

Organism-specific databases

WormBasei CBG00872 ; CBP34424 ; WBGene00024197 ; Cbr-sdhb-1.

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160590.
OrthoDBi EOG7H4DTN.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiSDHB_CAEBR
AccessioniPrimary (citable) accession number: A8WPF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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