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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity
  • [3Fe-4S] clusterBy similarityNote: Binds 1 [3Fe-4S] cluster.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi96Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi99Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi111Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi184Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi187Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi190Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi194Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei199Ubiquinone; shared with DHSDBy similarity1
Metal bindingi241Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi247Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi251Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialBy similarity (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex IIBy similarity
Short name:
IpBy similarity
Gene namesi
Name:sdhb-1Imported
ORF Names:CBG00872
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome II, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG00872; CBP34424; WBGene00024197; Cbr-sdhb-1.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000367044? – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSequence analysis
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi6238.CBG00872.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 1312Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST89
Domaini174 – 2044Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-AlaSequence analysis4

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
HOGENOMiHOG000160590.
InParanoidiA8WPF0.
OMAiFREANPP.
OrthoDBiEOG091G0EKC.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8WPF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARSALFVH SAELAANAAR AASGAAAAQP KKTGNRIKTF EIYRFNPEAP
60 70 80 90 100
GAKPTIQKFD VDLDQCGTMI LDALIKIKNE VDPTLTFRRS CREGICGSCA
110 120 130 140 150
MNIGGENTLA CICKIDADTS KSTKIYPLPH MFVVKDLVPD MNLFYAQYAS
160 170 180 190 200
IQPWIQKKTP LTLGEKQMHQ SVAERDRLDG LYECILCACC STSCPSYWWN
210 220 230 240 250
ADKYLGPAVL MQAYRWVIDS RDDYAQERLH RMHDSFSAFK CHTIMNCTKT
260 270 280
CPKHLNPAKA IGEIKSLLTG FKSKPAAEPS AF
Length:282
Mass (Da):31,343
Last modified:December 16, 2008 - v2
Checksum:i9A82F1BE0D05E8A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600951 Genomic DNA. Translation: CAP22357.2.

Genome annotation databases

EnsemblMetazoaiCBG00872; CBG00872; WBGene00024197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600951 Genomic DNA. Translation: CAP22357.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG00872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG00872; CBG00872; WBGene00024197.

Organism-specific databases

WormBaseiCBG00872; CBP34424; WBGene00024197; Cbr-sdhb-1.

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
HOGENOMiHOG000160590.
InParanoidiA8WPF0.
OMAiFREANPP.
OrthoDBiEOG091G0EKC.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_CAEBR
AccessioniPrimary (citable) accession number: A8WPF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.