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A8WP91

- ACAD2_CAEBR

UniProt

A8WP91 - ACAD2_CAEBR

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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrial

Gene

CBG00953

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521Substrate; via carbonyl oxygenBy similarity
Active sitei382 – 3821Proton acceptorBy similarity
Binding sitei383 – 3831Substrate; via amide nitrogenBy similarity
Binding sitei394 – 3941SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 15210FADBy similarity
Nucleotide bindingi176 – 1783FADBy similarity
Nucleotide bindingi291 – 2933FADBy similarity
Nucleotide bindingi301 – 3022FADBy similarity
Nucleotide bindingi355 – 3595FADBy similarity
Nucleotide bindingi384 – 3863FADBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrialBy similarity (EC:1.3.8.7)
Short name:
MCADBy similarity
Gene namesi
ORF Names:CBG00953
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG00953; CBP35999; WBGene00024257.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 55MitochondrionSequence Analysis
Chaini6 – 408403Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrialBy similarityPRO_0000395328Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi6238.CBG00953.

Structurei

3D structure databases

ProteinModelPortaliA8WP91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 2664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Sequence Analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
InParanoidiA8WP91.
OrthoDBiEOG74FF0S.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8WP91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRLARTQI SRSALLSQTR QLSFDLNETQ KEIQAAALKF SKEVLVPNAA
60 70 80 90 100
KFDESGEFPW EIIRQAHSLG LMNPQIPEKY GGPGMTTLET TLIVEALSYG
110 120 130 140 150
CTGLQLGIMG PSLAIAPVYI AGNEEQKKKY LGALAAEPII ASYCVTEPGA
160 170 180 190 200
GSDVNGVKTK CEKKGNEYII NGSKAWITGG GHAKWFFVLA RSDPNPKTPA
210 220 230 240 250
GKAFTAFIVD GDTSGITRGK KEKNMGQRCS DTRTITFEDV RVPEENVLGP
260 270 280 290 300
PGAGFKVAMS AFDMTRPGVA AGALGLSWRC LDESAKYALQ RKAFGTEIAN
310 320 330 340 350
HQAVQFMLSD MAINLELARL ITYKSATDVD NGVRSSYNAS KSASQRIPRI
360 370 380 390 400
RRLLMLFRCN GFNSEYPVEK LMRDAKIYQI YEGTSQIQRI VISRMLLGHV

AQNGTSRM
Length:408
Mass (Da):44,608
Last modified:December 16, 2008 - v2
Checksum:i0880122A2AB967D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600951 Genomic DNA. Translation: CAP22297.2.

Genome annotation databases

EnsemblMetazoaiCBG00953; CBG00953; CBG00953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600951 Genomic DNA. Translation: CAP22297.2 .

3D structure databases

ProteinModelPortali A8WP91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG00953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG00953 ; CBG00953 ; CBG00953 .

Organism-specific databases

WormBasei CBG00953 ; CBP35999 ; WBGene00024257 .

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
InParanoidi A8WP91.
OrthoDBi EOG74FF0S.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACAD2_CAEBR
AccessioniPrimary (citable) accession number: A8WP91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3