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A8WP91

- ACAD2_CAEBR

UniProt

A8WP91 - ACAD2_CAEBR

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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrial

Gene
CBG00953
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16 By similarity.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521Substrate; via carbonyl oxygen By similarityBy similarity
Active sitei382 – 3821Proton acceptor By similarityBy similarity
Binding sitei383 – 3831Substrate; via amide nitrogen By similarityBy similarity
Binding sitei394 – 3941Substrate By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 15210FAD By similarityBy similarity
Nucleotide bindingi176 – 1783FAD By similarityBy similarity
Nucleotide bindingi291 – 2933FAD By similarityBy similarity
Nucleotide bindingi301 – 3022FAD By similarityBy similarity
Nucleotide bindingi355 – 3595FAD By similarityBy similarity
Nucleotide bindingi384 – 3863FAD By similarityBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
ORF Names:CBG00953
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG00953; CBP35999; WBGene00024257.

Subcellular locationi

Mitochondrion matrix By similarity By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 55Mitochondrion Reviewed prediction
Chaini6 – 408403Probable medium-chain specific acyl-CoA dehydrogenase 2, mitochondrialBy similarityPRO_0000395328Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.By similarity

Protein-protein interaction databases

STRINGi6238.CBG00953.

Structurei

3D structure databases

ProteinModelPortaliA8WP91.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 2664Substrate binding By similarityBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
OrthoDBiEOG74FF0S.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8WP91-1 [UniParc]FASTAAdd to Basket

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MLSRLARTQI SRSALLSQTR QLSFDLNETQ KEIQAAALKF SKEVLVPNAA    50
KFDESGEFPW EIIRQAHSLG LMNPQIPEKY GGPGMTTLET TLIVEALSYG 100
CTGLQLGIMG PSLAIAPVYI AGNEEQKKKY LGALAAEPII ASYCVTEPGA 150
GSDVNGVKTK CEKKGNEYII NGSKAWITGG GHAKWFFVLA RSDPNPKTPA 200
GKAFTAFIVD GDTSGITRGK KEKNMGQRCS DTRTITFEDV RVPEENVLGP 250
PGAGFKVAMS AFDMTRPGVA AGALGLSWRC LDESAKYALQ RKAFGTEIAN 300
HQAVQFMLSD MAINLELARL ITYKSATDVD NGVRSSYNAS KSASQRIPRI 350
RRLLMLFRCN GFNSEYPVEK LMRDAKIYQI YEGTSQIQRI VISRMLLGHV 400
AQNGTSRM 408
Length:408
Mass (Da):44,608
Last modified:December 16, 2008 - v2
Checksum:i0880122A2AB967D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22297.2.

Genome annotation databases

EnsemblMetazoaiCBG00953; CBG00953; CBG00953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22297.2 .

3D structure databases

ProteinModelPortali A8WP91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG00953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG00953 ; CBG00953 ; CBG00953 .

Organism-specific databases

WormBasei CBG00953 ; CBP35999 ; WBGene00024257 .

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
OrthoDBi EOG74FF0S.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACAD2_CAEBR
AccessioniPrimary (citable) accession number: A8WP91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: November 13, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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