ID   A8WMV6_CAEBR            Unreviewed;       418 AA.
AC   A8WMV6;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE            EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN   ORFNames=CBG00344 {ECO:0000313|EMBL:CAP21811.1,
GN   ECO:0000313|WormBase:CBG00344}, CBG_00344
GN   {ECO:0000313|EMBL:CAP21811.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP21811.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP21811.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP21811.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC         Evidence={ECO:0000256|RuleBase:RU361203};
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC       acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR   EMBL; HE600968; CAP21811.1; -; Genomic_DNA.
DR   RefSeq; XP_002632335.1; XM_002632289.1.
DR   AlphaFoldDB; A8WMV6; -.
DR   STRING; 6238.A8WMV6; -.
DR   EnsemblMetazoa; CBG00344.1; CBG00344.1; WBGene00023748.
DR   GeneID; 8574332; -.
DR   KEGG; cbr:CBG_00344; -.
DR   CTD; 8574332; -.
DR   WormBase; CBG00344; CBP05722; WBGene00023748; -.
DR   eggNOG; KOG1378; Eukaryota.
DR   HOGENOM; CLU_013387_5_0_1; -.
DR   InParanoid; A8WMV6; -.
DR   OMA; MPRNGVY; -.
DR   OrthoDB; 203742at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd00839; MPP_PAPs; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041792; MPP_PAP.
DR   InterPro; IPR008963; Purple_acid_Pase-like_N.
DR   InterPro; IPR015914; Purple_acid_Pase_N.
DR   InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR   PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR   PANTHER; PTHR45867:SF2; PURPLE ACID PHOSPHATASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF14008; Metallophos_C; 1.
DR   Pfam; PF16656; Pur_ac_phosph_N; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|RuleBase:RU361203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|RuleBase:RU361203"
FT   CHAIN           19..418
FT                   /note="Purple acid phosphatase"
FT                   /evidence="ECO:0000256|RuleBase:RU361203"
FT                   /id="PRO_5005122056"
FT   DOMAIN          22..115
FT                   /note="Purple acid phosphatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16656"
FT   DOMAIN          124..324
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          349..411
FT                   /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14008"
SQ   SEQUENCE   418 AA;  47737 MW;  15710776A5C8ED7F CRC64;
     MILRVFAIFA TIFVAVSSKK VEQVHLSLSG KQDEMMVTWL TQDPLPNVTP YVAFGVTKDA
     LRLTAKGNST GWADQGKKKV MRYTHRATMN SLVPGQVYYY QVGSSQAMSD VFHFRQPDQS
     LPLRAAIFGD LSIYKGQQSI DQLIAARKNN QFDLIIHIGD LAYDLHDNDG DNGDDYMNAI
     QDFAAYVPYM VFAGNHEVDS NFNQIVNRFT MPKNGVYDNN LFWSFDYGFV HFIALNSEYY
     AEEMSKETQL QYKWLENDLA GNSKKWTIVM FHRPWYCSSK KKKGCHDDQD ILSRDGLKDK
     FPGLEELLNK YKVDLILYGH KHTYERMWPI FNAQPFKSQD PGHIKNAPAP VYILTGGAGC
     HSHEDPSDHI IQDFSVKALG EYGYTFLTVY NSTHLSTDYV DTSETSGEFL DPFVLEKD
//