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Protein

Cyclin-dependent kinase 20

Gene

cdk20

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
Cell cycle-related kinase
Cell division protein kinase 20
Gene namesi
Name:cdk20
Synonyms:ccrk
ORF Names:si:dkeyp-77f7.1, zgc:101530
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-041212-84 cdk20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Fish lacking cdk20 are viable during embryogenesis and early larval stages, but exhibit curvature of the body axis and curled cilia in distal kidney tubules.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003936161 – 344Cyclin-dependent kinase 20Add BLAST344

Proteomic databases

PaxDbiA8WIP6
PRIDEiA8WIP6

Expressioni

Gene expression databases

BgeeiENSDARG00000003867
ExpressionAtlasiA8WIP6 baseline

Interactioni

Subunit structurei

Monomer. Interacts with tbc1d32.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113146

Structurei

3D structure databases

ProteinModelPortaliA8WIP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0659 Eukaryota
ENOG410XQDH LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiA8WIP6
KOiK08817
OMAiLWGSQKY
OrthoDBiEOG091G0CI9
PhylomeDBiA8WIP6
TreeFamiTF327240

Family and domain databases

InterProiView protein in InterPro
IPR037770 CDK7
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24056:SF0 PTHR24056:SF0, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A8WIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYSILGRI GEGAHGIVFK AKHIETGETV ALKKVALRRL EDGIPNQALR
60 70 80 90 100
EIKALQEIED NQYVVKLKDV FPHGTGFVLV FEYMLSDLSE VIRNSQRPLT
110 120 130 140 150
ASQVKSYMMM LLKGVAFCHE NSIMHRDLKP ANLLISSTGH LKIADFGLAR
160 170 180 190 200
LFSNEGDRLY SHQVATRWYR APELLYGARK YDEGVDLWAV GCIFGELLNN
210 220 230 240 250
SPLFPGENDI EQLCCVLRVL GTPNQKVWPE ITELPDYNKI TFKENPPIPL
260 270 280 290 300
EEIVPDTSPQ AVDLLKKFLV YPSKQRISAR QALLHPYFFT DPLPAHHSEL
310 320 330 340
PIPQRGGKHS RQRMQPPHEF TVDRPLHESV VDPSLIQKHA MSCS
Length:344
Mass (Da):39,025
Last modified:January 15, 2008 - v1
Checksum:iD4C820FAF9C7FB62
GO

Sequence cautioni

The sequence AAH86697 differs from that shown. Reason: Frameshift at position 84.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571687 Genomic DNA Translation: CAP19557.1
BC086697 mRNA Translation: AAH86697.1 Frameshift.
RefSeqiNP_001008655.1, NM_001008655.1
XP_005166746.1, XM_005166689.3
UniGeneiDr.37814

Genome annotation databases

EnsembliENSDART00000140098; ENSDARP00000113146; ENSDARG00000003867
ENSDART00000176938; ENSDARP00000144381; ENSDARG00000003867
GeneIDi494112
KEGGidre:494112

Similar proteinsi

Entry informationi

Entry nameiCDK20_DANRE
AccessioniPrimary (citable) accession number: A8WIP6
Secondary accession number(s): Q5PRE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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