ID   A8WH42_XENLA            Unreviewed;       607 AA.
AC   A8WH42;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=LOC100127248 protein {ECO:0000313|EMBL:AAI54966.1};
DE   SubName: Full=Lactase, gene 1 L homeolog {ECO:0000313|RefSeq:NP_001106299.1};
GN   Name=lct.1.L {ECO:0000313|RefSeq:NP_001106299.1,
GN   ECO:0000313|Xenbase:XB-GENE-5930998};
GN   Synonyms=lac {ECO:0000313|RefSeq:NP_001106299.1}, lct
GN   {ECO:0000313|RefSeq:NP_001106299.1,
GN   ECO:0000313|Xenbase:XB-GENE-5930998}, lct.1
GN   {ECO:0000313|RefSeq:NP_001106299.1,
GN   ECO:0000313|Xenbase:XB-GENE-5930998}, lct.1.S
GN   {ECO:0000313|RefSeq:NP_001106299.1}, LOC100127248
GN   {ECO:0000313|EMBL:AAI54966.1}, lph
GN   {ECO:0000313|RefSeq:NP_001106299.1}, lph1
GN   {ECO:0000313|RefSeq:NP_001106299.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI54966.1};
RN   [1] {ECO:0000313|RefSeq:NP_001106299.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAI54966.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Intestine {ECO:0000313|EMBL:AAI54966.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001106299.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC       {ECO:0000256|RuleBase:RU003690}.
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DR   EMBL; BC154965; AAI54966.1; -; mRNA.
DR   RefSeq; NP_001106299.1; NM_001112828.1.
DR   CAZy; GH1; Glycoside Hydrolase Family 1.
DR   DNASU; 100127248; -.
DR   GeneID; 100127248; -.
DR   KEGG; xla:100127248; -.
DR   AGR; Xenbase:XB-GENE-5930998; -.
DR   CTD; 100127248; -.
DR   Xenbase; XB-GENE-5930998; lct.1.L.
DR   OrthoDB; 3373839at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100127248; Expressed in intestine and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF38; LACTASE_PHLORIZIN HYDROLASE; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 2.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        572..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          527..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..553
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        431
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   607 AA;  69253 MW;  764DCC64C42E3815 CRC64;
     MDTFEWNSGY SVRFGLHHVD FKNPSRPRTP KRSAIYYAEI IRNKGMPLSK EDEFLYGEFS
     KDFAWSVASA SYQIEGAWRA DGKSLSIWDQ YAHTPLRIGN DDNGDIACDS YNRIEQDVTA
     LKNLKVSHYR FSVSWSRILP DGTRNFVNEA GLNYYVRLID ALLVANISPQ VTLYHWDLPQ
     VLQNIGGWEN DTIVEKFKDY ADLLFQKLGD KVKFWITINE PYIVANLGYG YGTAAPGISS
     RPGRAPYIVG HNLIKAHAEA WHLYNDKYRA SQGGLISITI NSDWAEPRNP YKQEDVEAAR
     RYMMFYGGWF ANPIFNNGDY NEVMKSRVRE RSLASGLTQS RLPEFTESEK QRIKGTFDYF
     GFNHYTTILA SPFNLPISQQ TYDADRGVAS TTDHSWLGSG SFWLKVTPFG FRRILNWIKE
     EYNNPPILVT ENGISERGTD LNDVWREHYY KEYINEALKA VKYDGVDLRG YTAWSLMDNF
     EWATGFAERF GLHYTNYSDP ELARIPKKST KYYRSIILCN GFPDPSNGSP PCLEPETEGT
     TAPTVTTPPS GENQEEAVSF LGLEISPSDA EVALYVEFAF LIAAVLGIVL LSVFYRKLAK
     KPKMSNF
//