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Protein

UDP-glucose 6-dehydrogenase

Gene

ugdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.UniRule annotation

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Active sitei276NucleophileUniRule annotation1
Binding sitei346NADUniRule annotation1
Binding sitei444SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi89 – 93NADUniRule annotation5
Nucleotide bindingi130 – 131NADUniRule annotation2
Nucleotide bindingi276 – 279NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

  • atrioventricular valve formation Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • glycosaminoglycan biosynthetic process Source: GO_Central
  • heart development Source: ZFIN
  • heart valve formation Source: ZFIN
  • positive regulation of canonical Wnt signaling pathway Source: ZFIN
  • positive regulation of smoothened signaling pathway Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-173599 Formation of the active cofactor, UDP-glucuronate

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
Name:ugdhImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-011022-1 ugdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiA8WGP7

Expressioni

Gene expression databases

BgeeiENSDARG00000019838

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004687

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 449UDPG_MGDP_dh_CInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate bindingUniRule annotation5
Regioni220 – 224Substrate bindingUniRule annotation5
Regioni267 – 273Substrate bindingUniRule annotation7
Regioni338 – 339Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
KOiK00012
OMAiLCTEWDE
OrthoDBiEOG091G05RK
TreeFamiTF105671

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

A8WGP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQIKKICCI GAGYVGGPTC SVIASMCPEI TVTVVDVNES RIKAWNSDTL
60 70 80 90 100
PIYEPGLNEV VLSCRGKNLF FSTDIDSAIK EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKFIE ACARRIVEVS DGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
SLNLQVLSNP EFLAEGTAVK DLKEPDRVLI GGDETPEGQR AISALCAVYE
210 220 230 240 250
HWVPKTRIIT TNTWSSELSK LAANAFLAQR ISSINSISAL CESTGADVEE
260 270 280 290 300
VARAIGMDQR IGSKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVASYW
310 320 330 340 350
QQVIDMNEYQ RKRFACRIID CLFNTVTGKK IALLGFSFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAKLHIYDPK VLKEQIIQDL SQPGISGDNP ERVSDLVTVT
410 420 430 440 450
VDPYEACESA HALVICTEWD MFKDLDYEKI YHKMLKPAFI FDGRRVLDHL
460 470 480 490
HTQLQNVGFQ IETIGKKVMT RIPFTTSGGV PRITEPPVKK SKA
Length:493
Mass (Da):54,578
Last modified:January 15, 2008 - v1
Checksum:i32B77140369F5992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759875 Genomic DNA No translation available.
BC154794 mRNA Translation: AAI54795.1
RefSeqiNP_001103872.1, NM_001110402.1
UniGeneiDr.78436

Genome annotation databases

EnsembliENSDART00000013263; ENSDARP00000004687; ENSDARG00000019838
ENSDART00000122648; ENSDARP00000108630; ENSDARG00000019838
GeneIDi116991
KEGGidre:116991

Similar proteinsi

Entry informationi

Entry nameiA8WGP7_DANRE
AccessioniPrimary (citable) accession number: A8WGP7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health