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Protein

UDP-glucose 6-dehydrogenase

Gene

ugdh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.UniRule annotation

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Active sitei276NucleophileUniRule annotation1
Binding sitei346NADUniRule annotation1
Binding sitei444SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi89 – 93NADUniRule annotation5
Nucleotide bindingi130 – 131NADUniRule annotation2
Nucleotide bindingi276 – 279NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

  • atrioventricular valve formation Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • glycosaminoglycan biosynthetic process Source: GO_Central
  • heart development Source: ZFIN
  • heart valve formation Source: ZFIN
  • positive regulation of canonical Wnt signaling pathway Source: ZFIN
  • positive regulation of smoothened signaling pathway Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-173599. Formation of the active cofactor, UDP-glucuronate.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
Name:ugdhImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-011022-1. ugdh.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSDARG00000019838.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004687.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 449UDPG_MGDP_dh_CInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate bindingUniRule annotation5
Regioni220 – 224Substrate bindingUniRule annotation5
Regioni267 – 273Substrate bindingUniRule annotation7
Regioni338 – 339Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2666. Eukaryota.
COG1004. LUCA.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
HOVERGENiHBG003512.
KOiK00012.
OMAiLCTEWDE.
OrthoDBiEOG091G05RK.
TreeFamiTF105671.

Family and domain databases

InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
PfamiView protein in Pfam
PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiView protein in SMART
SM00984. UDPG_MGDP_dh_C. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

A8WGP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQIKKICCI GAGYVGGPTC SVIASMCPEI TVTVVDVNES RIKAWNSDTL
60 70 80 90 100
PIYEPGLNEV VLSCRGKNLF FSTDIDSAIK EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKFIE ACARRIVEVS DGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
SLNLQVLSNP EFLAEGTAVK DLKEPDRVLI GGDETPEGQR AISALCAVYE
210 220 230 240 250
HWVPKTRIIT TNTWSSELSK LAANAFLAQR ISSINSISAL CESTGADVEE
260 270 280 290 300
VARAIGMDQR IGSKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVASYW
310 320 330 340 350
QQVIDMNEYQ RKRFACRIID CLFNTVTGKK IALLGFSFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAKLHIYDPK VLKEQIIQDL SQPGISGDNP ERVSDLVTVT
410 420 430 440 450
VDPYEACESA HALVICTEWD MFKDLDYEKI YHKMLKPAFI FDGRRVLDHL
460 470 480 490
HTQLQNVGFQ IETIGKKVMT RIPFTTSGGV PRITEPPVKK SKA
Length:493
Mass (Da):54,578
Last modified:January 15, 2008 - v1
Checksum:i32B77140369F5992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759875 Genomic DNA. No translation available.
BC154794 mRNA. Translation: AAI54795.1.
RefSeqiNP_001103872.1. NM_001110402.1.
UniGeneiDr.78436.

Genome annotation databases

EnsembliENSDART00000013263; ENSDARP00000004687; ENSDARG00000019838.
ENSDART00000122648; ENSDARP00000108630; ENSDARG00000019838.
GeneIDi116991.
KEGGidre:116991.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8WGP7_DANRE
AccessioniPrimary (citable) accession number: A8WGP7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported