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A8WGP3 (PP4CA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit A

Short name=PP4C-A
EC=3.1.3.16
Gene names
Name:ppp4ca
Synonyms:pp4c
ORF Names:zgc:56413
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   LigandIron
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Serine/threonine-protein phosphatase 4 catalytic subunit A
PRO_0000353206

Sites

Active site1191Proton donor By similarity
Metal binding581Iron By similarity
Metal binding601Iron By similarity
Metal binding861Iron By similarity
Metal binding861Manganese By similarity
Metal binding1181Manganese By similarity
Metal binding1681Manganese By similarity
Metal binding2421Manganese By similarity

Amino acid modifications

Modified residue3111Leucine methyl ester By similarity

Experimental info

Sequence conflict1281Y → H in AAH49430. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A8WGP3 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: C9D785FD393887F5

FASTA31135,456
        10         20         30         40         50         60 
MCVIMGDFTD LDRQIEQLRR CELIKENEVK ALCAKAREIL VEESNVQSVD SPVTVCGDIH 

        70         80         90        100        110        120 
GQFYDLKELF RVGGEVPETN YLFMGDFVDR GFYSVETFLL LLALKVRYPD RITLIRGNHE 

       130        140        150        160        170        180 
SRQITQVYGF FDECHRKYGS ATVWRYCTEI FDYLSLSAIV DGKIFCVHGG LSPSIQTLDQ 

       190        200        210        220        230        240 
IRTIDRKQEV PHDGPMCDLL WSDPEDTTGW GVSPRGAGYL FGSDVVAQFN AANDISMICR 

       250        260        270        280        290        300 
AHQLVMEGYK WHFNDTVLTV WSAPNYCYRC GNVAAILELD EHLQKEFIIF EAAPQETRGL 

       310 
PSKKPVADYF L 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC049430 mRNA. Translation: AAH49430.1.
BC154790 mRNA. Translation: AAI54791.1.
RefSeqNP_001103884.1. NM_001110414.1.
UniGeneDr.75739.

3D structure databases

ProteinModelPortalA8WGP3.
SMRA8WGP3. Positions 10-311.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA8WGP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570.
GeneID100003080.
KEGGdre:100003080.

Organism-specific databases

CTD100003080.
ZFINZDB-GENE-030131-4433. ppp4ca.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
HOVERGENHBG000216.
InParanoidQ7ZWF9.
KOK15423.
OMANDISMIC.
OrthoDBEOG74N5H2.
PhylomeDBA8WGP3.
TreeFamTF105559.

Gene expression databases

BgeeA8WGP3.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20785711.

Entry information

Entry namePP4CA_DANRE
AccessionPrimary (citable) accession number: A8WGP3
Secondary accession number(s): Q7ZWF9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families