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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit A

Gene

ppp4ca

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Manganese 1By similarity1
Metal bindingi60Manganese 1By similarity1
Metal bindingi86Manganese 1By similarity1
Metal bindingi86Manganese 2By similarity1
Metal bindingi118Manganese 2By similarity1
Active sitei119Proton donorBy similarity1
Metal bindingi168Manganese 2By similarity1
Metal bindingi242Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • brain development Source: ZFIN
  • central nervous system projection neuron axonogenesis Source: ZFIN
  • determination of ventral identity Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-204005 COPII (Coat Protein 2) Mediated Vesicle Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit A (EC:3.1.3.16)
Short name:
PP4C-A
Gene namesi
Name:ppp4ca
Synonyms:pp4c
ORF Names:zgc:56413
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-030131-4433 ppp4ca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003532061 – 311Serine/threonine-protein phosphatase 4 catalytic subunit AAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei311Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiA8WGP3
PeptideAtlasiA8WGP3
PRIDEiA8WGP3

Expressioni

Gene expression databases

BgeeiENSDARG00000070570
ExpressionAtlasiA8WGP3 baseline and differential

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094516

Structurei

3D structure databases

ProteinModelPortaliA8WGP3
SMRiA8WGP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00550000074618
HOGENOMiHOG000172696
HOVERGENiHBG000216
InParanoidiA8WGP3
KOiK15423
OMAiNRIFCTH
OrthoDBiEOG091G0B6S
PhylomeDBiA8WGP3
TreeFamiTF105559

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8WGP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIMGDFTD LDRQIEQLRR CELIKENEVK ALCAKAREIL VEESNVQSVD
60 70 80 90 100
SPVTVCGDIH GQFYDLKELF RVGGEVPETN YLFMGDFVDR GFYSVETFLL
110 120 130 140 150
LLALKVRYPD RITLIRGNHE SRQITQVYGF FDECHRKYGS ATVWRYCTEI
160 170 180 190 200
FDYLSLSAIV DGKIFCVHGG LSPSIQTLDQ IRTIDRKQEV PHDGPMCDLL
210 220 230 240 250
WSDPEDTTGW GVSPRGAGYL FGSDVVAQFN AANDISMICR AHQLVMEGYK
260 270 280 290 300
WHFNDTVLTV WSAPNYCYRC GNVAAILELD EHLQKEFIIF EAAPQETRGL
310
PSKKPVADYF L
Length:311
Mass (Da):35,456
Last modified:January 15, 2008 - v1
Checksum:iC9D785FD393887F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128Y → H in AAH49430 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049430 mRNA Translation: AAH49430.1
BC154790 mRNA Translation: AAI54791.1
RefSeqiNP_001103884.1, NM_001110414.1
UniGeneiDr.75739

Genome annotation databases

EnsembliENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570
GeneIDi100003080
KEGGidre:100003080

Similar proteinsi

Entry informationi

Entry nameiPP4CA_DANRE
AccessioniPrimary (citable) accession number: A8WGP3
Secondary accession number(s): Q7ZWF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health