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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit A

Gene

ppp4ca

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Manganese 1By similarity
Metal bindingi60 – 601Manganese 1By similarity
Metal bindingi86 – 861Manganese 1By similarity
Metal bindingi86 – 861Manganese 2By similarity
Metal bindingi118 – 1181Manganese 2By similarity
Active sitei119 – 1191Proton donorBy similarity
Metal bindingi168 – 1681Manganese 2By similarity
Metal bindingi242 – 2421Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit A (EC:3.1.3.16)
Short name:
PP4C-A
Gene namesi
Name:ppp4ca
Synonyms:pp4c
ORF Names:zgc:56413
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-030131-4433. ppp4ca.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Serine/threonine-protein phosphatase 4 catalytic subunit APRO_0000353206Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei311 – 3111Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiA8WGP3.

Expressioni

Gene expression databases

BgeeiA8WGP3.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094516.

Structurei

3D structure databases

ProteinModelPortaliA8WGP3.
SMRiA8WGP3. Positions 10-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
InParanoidiA8WGP3.
KOiK15423.
OMAiNDISMIC.
OrthoDBiEOG74N5H2.
PhylomeDBiA8WGP3.
TreeFamiTF105559.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8WGP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIMGDFTD LDRQIEQLRR CELIKENEVK ALCAKAREIL VEESNVQSVD
60 70 80 90 100
SPVTVCGDIH GQFYDLKELF RVGGEVPETN YLFMGDFVDR GFYSVETFLL
110 120 130 140 150
LLALKVRYPD RITLIRGNHE SRQITQVYGF FDECHRKYGS ATVWRYCTEI
160 170 180 190 200
FDYLSLSAIV DGKIFCVHGG LSPSIQTLDQ IRTIDRKQEV PHDGPMCDLL
210 220 230 240 250
WSDPEDTTGW GVSPRGAGYL FGSDVVAQFN AANDISMICR AHQLVMEGYK
260 270 280 290 300
WHFNDTVLTV WSAPNYCYRC GNVAAILELD EHLQKEFIIF EAAPQETRGL
310
PSKKPVADYF L
Length:311
Mass (Da):35,456
Last modified:January 15, 2008 - v1
Checksum:iC9D785FD393887F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281Y → H in AAH49430 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049430 mRNA. Translation: AAH49430.1.
BC154790 mRNA. Translation: AAI54791.1.
RefSeqiNP_001103884.1. NM_001110414.1.
UniGeneiDr.75739.

Genome annotation databases

EnsembliENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570.
GeneIDi100003080.
KEGGidre:100003080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049430 mRNA. Translation: AAH49430.1.
BC154790 mRNA. Translation: AAI54791.1.
RefSeqiNP_001103884.1. NM_001110414.1.
UniGeneiDr.75739.

3D structure databases

ProteinModelPortaliA8WGP3.
SMRiA8WGP3. Positions 10-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094516.

Proteomic databases

PRIDEiA8WGP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570.
GeneIDi100003080.
KEGGidre:100003080.

Organism-specific databases

CTDi100003080.
ZFINiZDB-GENE-030131-4433. ppp4ca.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
InParanoidiA8WGP3.
KOiK15423.
OMAiNDISMIC.
OrthoDBiEOG74N5H2.
PhylomeDBiA8WGP3.
TreeFamiTF105559.

Miscellaneous databases

NextBioi20785711.
PROiA8WGP3.

Gene expression databases

BgeeiA8WGP3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPP4CA_DANRE
AccessioniPrimary (citable) accession number: A8WGP3
Secondary accession number(s): Q7ZWF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.