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A8WGP3

- PP4CA_DANRE

UniProt

A8WGP3 - PP4CA_DANRE

Protein

Serine/threonine-protein phosphatase 4 catalytic subunit A

Gene

ppp4ca

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi58 – 581Manganese 1By similarity
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi86 – 861Manganese 1By similarity
    Metal bindingi86 – 861Manganese 2By similarity
    Metal bindingi118 – 1181Manganese 2By similarity
    Active sitei119 – 1191Proton donorBy similarity
    Metal bindingi168 – 1681Manganese 2By similarity
    Metal bindingi242 – 2421Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit A (EC:3.1.3.16)
    Short name:
    PP4C-A
    Gene namesi
    Name:ppp4ca
    Synonyms:pp4c
    ORF Names:zgc:56413
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 3

    Organism-specific databases

    ZFINiZDB-GENE-030131-4433. ppp4ca.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Serine/threonine-protein phosphatase 4 catalytic subunit APRO_0000353206Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei311 – 3111Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiA8WGP3.

    Expressioni

    Gene expression databases

    BgeeiA8WGP3.

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA8WGP3.
    SMRiA8WGP3. Positions 10-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    HOVERGENiHBG000216.
    InParanoidiQ7ZWF9.
    KOiK15423.
    OMAiNDISMIC.
    OrthoDBiEOG74N5H2.
    PhylomeDBiA8WGP3.
    TreeFamiTF105559.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8WGP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCVIMGDFTD LDRQIEQLRR CELIKENEVK ALCAKAREIL VEESNVQSVD    50
    SPVTVCGDIH GQFYDLKELF RVGGEVPETN YLFMGDFVDR GFYSVETFLL 100
    LLALKVRYPD RITLIRGNHE SRQITQVYGF FDECHRKYGS ATVWRYCTEI 150
    FDYLSLSAIV DGKIFCVHGG LSPSIQTLDQ IRTIDRKQEV PHDGPMCDLL 200
    WSDPEDTTGW GVSPRGAGYL FGSDVVAQFN AANDISMICR AHQLVMEGYK 250
    WHFNDTVLTV WSAPNYCYRC GNVAAILELD EHLQKEFIIF EAAPQETRGL 300
    PSKKPVADYF L 311
    Length:311
    Mass (Da):35,456
    Last modified:January 15, 2008 - v1
    Checksum:iC9D785FD393887F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281Y → H in AAH49430. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049430 mRNA. Translation: AAH49430.1.
    BC154790 mRNA. Translation: AAI54791.1.
    RefSeqiNP_001103884.1. NM_001110414.1.
    UniGeneiDr.75739.

    Genome annotation databases

    EnsembliENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570.
    GeneIDi100003080.
    KEGGidre:100003080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049430 mRNA. Translation: AAH49430.1 .
    BC154790 mRNA. Translation: AAI54791.1 .
    RefSeqi NP_001103884.1. NM_001110414.1.
    UniGenei Dr.75739.

    3D structure databases

    ProteinModelPortali A8WGP3.
    SMRi A8WGP3. Positions 10-311.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A8WGP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000103741 ; ENSDARP00000094516 ; ENSDARG00000070570 .
    GeneIDi 100003080.
    KEGGi dre:100003080.

    Organism-specific databases

    CTDi 100003080.
    ZFINi ZDB-GENE-030131-4433. ppp4ca.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    HOVERGENi HBG000216.
    InParanoidi Q7ZWF9.
    KOi K15423.
    OMAi NDISMIC.
    OrthoDBi EOG74N5H2.
    PhylomeDBi A8WGP3.
    TreeFami TF105559.

    Miscellaneous databases

    NextBioi 20785711.

    Gene expression databases

    Bgeei A8WGP3.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPP4CA_DANRE
    AccessioniPrimary (citable) accession number: A8WGP3
    Secondary accession number(s): Q7ZWF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3