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A8WGP3

- PP4CA_DANRE

UniProt

A8WGP3 - PP4CA_DANRE

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Protein
Serine/threonine-protein phosphatase 4 catalytic subunit A
Gene
ppp4ca, pp4c, zgc:56413
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein phosphatase that regulates many processes such as microtubule organization at centrosomes By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Manganese 1 By similarity
Metal bindingi60 – 601Manganese 1 By similarity
Metal bindingi86 – 861Manganese 1 By similarity
Metal bindingi86 – 861Manganese 2 By similarity
Metal bindingi118 – 1181Manganese 2 By similarity
Active sitei119 – 1191Proton donor By similarity
Metal bindingi168 – 1681Manganese 2 By similarity
Metal bindingi242 – 2421Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit A (EC:3.1.3.16)
Short name:
PP4C-A
Gene namesi
Name:ppp4ca
Synonyms:pp4c
ORF Names:zgc:56413
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-030131-4433. ppp4ca.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Serine/threonine-protein phosphatase 4 catalytic subunit A
PRO_0000353206Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei311 – 3111Leucine methyl ester By similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiA8WGP3.

Expressioni

Gene expression databases

BgeeiA8WGP3.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliA8WGP3.
SMRiA8WGP3. Positions 10-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
InParanoidiQ7ZWF9.
KOiK15423.
OMAiNDISMIC.
OrthoDBiEOG74N5H2.
PhylomeDBiA8WGP3.
TreeFamiTF105559.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8WGP3-1 [UniParc]FASTAAdd to Basket

« Hide

MCVIMGDFTD LDRQIEQLRR CELIKENEVK ALCAKAREIL VEESNVQSVD    50
SPVTVCGDIH GQFYDLKELF RVGGEVPETN YLFMGDFVDR GFYSVETFLL 100
LLALKVRYPD RITLIRGNHE SRQITQVYGF FDECHRKYGS ATVWRYCTEI 150
FDYLSLSAIV DGKIFCVHGG LSPSIQTLDQ IRTIDRKQEV PHDGPMCDLL 200
WSDPEDTTGW GVSPRGAGYL FGSDVVAQFN AANDISMICR AHQLVMEGYK 250
WHFNDTVLTV WSAPNYCYRC GNVAAILELD EHLQKEFIIF EAAPQETRGL 300
PSKKPVADYF L 311
Length:311
Mass (Da):35,456
Last modified:January 15, 2008 - v1
Checksum:iC9D785FD393887F5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281Y → H in AAH49430. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049430 mRNA. Translation: AAH49430.1.
BC154790 mRNA. Translation: AAI54791.1.
RefSeqiNP_001103884.1. NM_001110414.1.
UniGeneiDr.75739.

Genome annotation databases

EnsembliENSDART00000103741; ENSDARP00000094516; ENSDARG00000070570.
GeneIDi100003080.
KEGGidre:100003080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049430 mRNA. Translation: AAH49430.1 .
BC154790 mRNA. Translation: AAI54791.1 .
RefSeqi NP_001103884.1. NM_001110414.1.
UniGenei Dr.75739.

3D structure databases

ProteinModelPortali A8WGP3.
SMRi A8WGP3. Positions 10-311.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A8WGP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000103741 ; ENSDARP00000094516 ; ENSDARG00000070570 .
GeneIDi 100003080.
KEGGi dre:100003080.

Organism-specific databases

CTDi 100003080.
ZFINi ZDB-GENE-030131-4433. ppp4ca.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
HOVERGENi HBG000216.
InParanoidi Q7ZWF9.
KOi K15423.
OMAi NDISMIC.
OrthoDBi EOG74N5H2.
PhylomeDBi A8WGP3.
TreeFami TF105559.

Miscellaneous databases

NextBioi 20785711.

Gene expression databases

Bgeei A8WGP3.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPP4CA_DANRE
AccessioniPrimary (citable) accession number: A8WGP3
Secondary accession number(s): Q7ZWF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi