ID   LAMP5_DANRE             Reviewed;         275 AA.
AC   A8WFR0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Lysosome-associated membrane glycoprotein 5;
DE   AltName: Full=Lysosome-associated membrane protein 5;
DE            Short=LAMP-5;
DE   Flags: Precursor;
GN   Name=lamp5; ORFNames=zgc:165600;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in short-term synaptic plasticity in a subset of
CC       GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q9D387}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Cell
CC       projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Recycling
CC       endosome {ECO:0000250|UniProtKB:Q9D387}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UJQ1};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I
CC       membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000305}.
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DR   EMBL; BC154416; AAI54417.1; -; mRNA.
DR   RefSeq; NP_001107133.1; NM_001113661.1.
DR   AlphaFoldDB; A8WFR0; -.
DR   SMR; A8WFR0; -.
DR   STRING; 7955.ENSDARP00000130608; -.
DR   GlyCosmos; A8WFR0; 2 sites, No reported glycans.
DR   PeptideAtlas; A8WFR0; -.
DR   GeneID; 100006791; -.
DR   KEGG; dre:100006791; -.
DR   AGR; ZFIN:ZDB-GENE-080220-19; -.
DR   ZFIN; ZDB-GENE-080220-19; zgc:165600.
DR   InParanoid; A8WFR0; -.
DR   OrthoDB; 5354428at2759; -.
DR   PRO; PR:A8WFR0; -.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR   GO; GO:0032584; C:growth cone membrane; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR048528; Lamp2-like_luminal.
DR   InterPro; IPR018134; LAMP_CS.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN; 1.
DR   PANTHER; PTHR11506:SF35; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5; 1.
DR   Pfam; PF01299; Lamp; 1.
DR   PROSITE; PS00310; LAMP_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasmic vesicle; Endosome;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..275
FT                   /note="Lysosome-associated membrane glycoprotein 5"
FT                   /id="PRO_0000360415"
FT   TOPO_DOM        19..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   275 AA;  30686 MW;  20452432C6B9A8C5 CRC64;
     MEFQLLLLCS VWALGVCAEQ EVENLSGLST NPERDIFVVR ENGTTCLMAE FAVRFLIPYD
     VLALNGIDLI TEQTSVAIPR GAQIAGKCGP SESELQISWA AQAFNFHIYF SKEKRVQGSD
     GKAPEAEVWK INRVQLVYDT SENTHFINAY NPGKHTASTH RLSALVTPAG RSYVCAAQQT
     LTLISSDHQK GVTVSIYDIQ IQPFDINADF VFSEPYKCVT DQREQLEQTL PLVLGLILGL
     IIVITISVYH FHLKLNAAHT QQPTLPRDRS LYKNM
//