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Protein

Lysosome-associated membrane glycoprotein 5

Gene

lamp5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:lamp5
ORF Names:zgc:165600
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-080220-19. zgc:165600.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 228210ExtracellularSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Topological domaini250 – 27526CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 275257Lysosome-associated membrane glycoprotein 5PRO_0000360415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051186.
InParanoidiA8WFR0.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8WFR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFQLLLLCS VWALGVCAEQ EVENLSGLST NPERDIFVVR ENGTTCLMAE
60 70 80 90 100
FAVRFLIPYD VLALNGIDLI TEQTSVAIPR GAQIAGKCGP SESELQISWA
110 120 130 140 150
AQAFNFHIYF SKEKRVQGSD GKAPEAEVWK INRVQLVYDT SENTHFINAY
160 170 180 190 200
NPGKHTASTH RLSALVTPAG RSYVCAAQQT LTLISSDHQK GVTVSIYDIQ
210 220 230 240 250
IQPFDINADF VFSEPYKCVT DQREQLEQTL PLVLGLILGL IIVITISVYH
260 270
FHLKLNAAHT QQPTLPRDRS LYKNM
Length:275
Mass (Da):30,686
Last modified:January 15, 2008 - v1
Checksum:i20452432C6B9A8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC154416 mRNA. Translation: AAI54417.1.
RefSeqiNP_001107133.1. NM_001113661.1.
UniGeneiDr.67298.

Genome annotation databases

GeneIDi100006791.
KEGGidre:100006791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC154416 mRNA. Translation: AAI54417.1.
RefSeqiNP_001107133.1. NM_001113661.1.
UniGeneiDr.67298.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100006791.
KEGGidre:100006791.

Organism-specific databases

ZFINiZDB-GENE-080220-19. zgc:165600.

Phylogenomic databases

HOVERGENiHBG051186.
InParanoidiA8WFR0.

Miscellaneous databases

NextBioi20787271.
PROiA8WFR0.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiLAMP5_DANRE
AccessioniPrimary (citable) accession number: A8WFR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 15, 2008
Last modified: April 29, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.