ID   A8W7U2_PANGU            Unreviewed;       427 AA.
AC   A8W7U2;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   22-FEB-2023, entry version 48.
DE   SubName: Full=Axin 2 {ECO:0000313|EMBL:ABW82156.1};
DE   Flags: Fragment;
OS   Pantherophis guttatus (Corn snake) (Elaphe guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Colubrinae; Pantherophis.
OX   NCBI_TaxID=94885 {ECO:0000313|EMBL:ABW82156.1};
RN   [1] {ECO:0000313|EMBL:ABW82156.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gomez C.E., Pourquie O.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABW82156.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18563087; DOI=10.1038/nature07020;
RA   Gomez C., Ozbudak E.M., Wunderlich J., Baumann D., Lewis J., Pourquie O.;
RT   "Control of segment number in vertebrate embryos.";
RL   Nature 454:335-339(2008).
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DR   EMBL; EU196456; ABW82156.1; -; mRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR   CDD; cd08707; RGS_Axin; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR043581; Axin-like.
DR   InterPro; IPR014936; Axin_b-cat-bd.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR46102; AXIN; 1.
DR   PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR   Pfam; PF08833; Axin_b-cat_bind; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          1..113
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          214..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABW82156.1"
FT   NON_TER         427
FT                   /evidence="ECO:0000313|EMBL:ABW82156.1"
SQ   SEQUENCE   427 AA;  47904 MW;  673988E6D9779107 CRC64;
     XQDGAYLFRT FLEREKCVDT LDFWFACNGF RQMDLKDAKT LRVAKAIYKR YIENNSIVSK
     QLKPATKTYI RDNIKKQQID SVMFDQAQTE IQTVMEENAY QMFLTSDIYL EYVRSGGENP
     AYINSNGLGS LKVDCGYLPT LNEEEEWSCA DLKNKLLPSI LGLSSKTLRA TASVRATETV
     ENGFRSFKRN DPVNPYHVNS GYVFAPATSA NDSEISSDAL TDDSMSMTDS SVDGIPPYRI
     GSKKQLQREM HRSVKANGQV SLPHFPRTHR LPKEMTPVEP ATFAAELISR LEKLKREQET
     MDCLEERLQQ ITEDDEKEIS DTPVAAQGNR ELVAVQHQQH PLTLLPTGSY EDDPQAILDD
     HLSRVLKTPG CQSPGMGRHS PRARSPDRLP GGKFLLATPG KNAVPAACAL LSKGFVTKQT
     TKHIHHH
//