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Protein

Aquaporin-5

Gene

AQP5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SSC-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:AQP5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 363ExtracellularSequence analysis
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 8730CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12618ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 16114CytoplasmicSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 20523ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 26539CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Aquaporin-5PRO_0000327507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA8W649.

Expressioni

Gene expression databases

GenevisibleiA8W649. SS.

Interactioni

Subunit structurei

Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000223.

Structurei

3D structure databases

ProteinModelPortaliA8W649.
SMRiA8W649. Positions 7-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 713NPA 1
Motifi185 – 1873NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiA8W649.
KOiK09867.
OMAiLVPNSMS.
OrthoDBiEOG7N8ZWD.
TreeFamiTF312940.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8W649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEVCSLAF LKAVFAEFLA TLIFVFFGLA SALKWPSALP TILQIALAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLVGN QISLLRAVFY VVAQLVGAIA
110 120 130 140 150
GAGILYGLAP GNARGNLAVN SLNNNTTPGQ AVVVEMILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAAVAAIL YFYLLFPNSL SLSERVAVVK GTYESEEDWE
260
EQREERKKTM ELTAH
Length:265
Mass (Da):28,146
Last modified:January 15, 2008 - v1
Checksum:iDF9A33F09155783A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU192130 mRNA. Translation: ABW69254.1.
RefSeqiNP_001103894.1. NM_001110424.1.
UniGeneiSsc.58858.

Genome annotation databases

EnsembliENSSSCT00000000226; ENSSSCP00000000223; ENSSSCG00000000211.
GeneIDi100126278.
KEGGissc:100126278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU192130 mRNA. Translation: ABW69254.1.
RefSeqiNP_001103894.1. NM_001110424.1.
UniGeneiSsc.58858.

3D structure databases

ProteinModelPortaliA8W649.
SMRiA8W649. Positions 7-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000223.

Proteomic databases

PaxDbiA8W649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000000226; ENSSSCP00000000223; ENSSSCG00000000211.
GeneIDi100126278.
KEGGissc:100126278.

Organism-specific databases

CTDi362.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiA8W649.
KOiK09867.
OMAiLVPNSMS.
OrthoDBiEOG7N8ZWD.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-SSC-432047. Passive transport by Aquaporins.

Gene expression databases

GenevisibleiA8W649. SS.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of porcine aquaporin 5 (SAQP5)."
    Zhang Z.-Q., Wang Y.-L., Yang G.-Y., Wang W.-J., Tai Y.-L., Han L.-Q.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAQP5_PIG
AccessioniPrimary (citable) accession number: A8W649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.