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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Hydrogenivirga sp. 128-5-R1-1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
ORF Names:HG1285_02133Imported
OrganismiHydrogenivirga sp. 128-5-R1-1Imported
Taxonomic identifieri392423 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenivirga
Proteomesi
  • UP000005981 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 45HelicalUniRule annotationAdd BLAST24
Transmembranei75 – 93HelicalUniRule annotationAdd BLAST19
Transmembranei99 – 120HelicalUniRule annotationAdd BLAST22
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 191HelicalUniRule annotationAdd BLAST20
Transmembranei198 – 217HelicalUniRule annotationAdd BLAST20
Transmembranei237 – 254HelicalUniRule annotationAdd BLAST18
Transmembranei261 – 280HelicalUniRule annotationAdd BLAST20
Transmembranei286 – 309HelicalUniRule annotationAdd BLAST24
Transmembranei337 – 356HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A8UQI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYHLAILLR EHFFAFNVLK YITFRSFTAI LLAFFITLIL SPTFMKKFAK
60 70 80 90 100
IQRLFGGYVR EYTPEHHESK KYTPTMGGVV IVTVILITSV LLMRLDIRYT
110 120 130 140 150
WVLVFSTLSF ALIGFVDDWI KLKNKKGLSI KAKLAFQMSF ALAVSLLIFY
160 170 180 190 200
WVGLETKLYF PFFKELTVDL GWLYIPFSMF IIVGTANAVN LTDGLDGLAI
210 220 230 240 250
GPSMTTATAF GVIAYVVGHS KIAQYLGVPH VPYAGEITVF CFAIIGAGLG
260 270 280 290 300
FLWFNTYPAQ VFMGDVGALG LGAALATVSI MTKSEFLLAV AGGVFVFETV
310 320 330 340 350
TVILQIIYFR ATGGKRLFRK APFHHHLEEK GLDEPKIVVR MWIVSALLAI

VSVAMLKLR
Length:359
Mass (Da):40,093
Last modified:January 15, 2008 - v1
Checksum:i9A36A52C856EFCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABHJ01000001 Genomic DNA. Translation: EDP76367.1.
RefSeqiWP_008285871.1. NZ_ABHJ01000001.1.

Genome annotation databases

EnsemblBacteriaiEDP76367; EDP76367; HG1285_02133.
PATRICifig|392423.7.peg.3483.

Similar proteinsi

Entry informationi

Entry nameiA8UQI5_9AQUI
AccessioniPrimary (citable) accession number: A8UQI5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 27, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported