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Protein

Collagen alpha-5(VI) chain

Gene

COL6A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-186797. Signaling by PDGF.
R-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-419037. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-5(VI) chain
Alternative name(s):
Collagen alpha-1(XXIX) chain
von Willebrand factor A domain-containing protein 4
Gene namesi
Name:COL6A5
Synonyms:COL29A1, VWA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26674. COL6A5.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular region Source: MGI
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Patients affected by atopic dermatitis display an abnormal distribution of COL29A1 mRNA and protein in skin suggesting that COL29A1 may be involved in the pathogenesis of the disease.

Organism-specific databases

PharmGKBiPA165696956.

Chemistry

ChEMBLiCHEMBL2364188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 26152597Collagen alpha-5(VI) chainPRO_5000294475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence analysis
Glycosylationi2509 – 25091N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiA8TX70.
PRIDEiA8TX70.

PTM databases

iPTMnetiA8TX70.
PhosphoSiteiA8TX70.

Expressioni

Tissue specificityi

Expressed in skin, followed by lung, small intestine, colon and testis. In skin, it is expressed in the epidermis with strongest staining in suprabasal viable layers. In ATOD patients, it is absent in the most differentiated upper spinous and granular layers (at protein level).1 Publication

Gene expression databases

BgeeiA8TX70.
ExpressionAtlasiA8TX70. baseline and differential.
GenevisibleiA8TX70. HS.

Organism-specific databases

HPAiHPA043138.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI).Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000265379.

Structurei

3D structure databases

ProteinModelPortaliA8TX70.
SMRiA8TX70. Positions 30-204, 232-1332, 1400-1425, 1433-1461, 1566-1594, 1632-1657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 209180VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini236 – 413178VWFA 2PROSITE-ProRule annotationAdd
BLAST
Domaini442 – 612171VWFA 3PROSITE-ProRule annotationAdd
BLAST
Domaini628 – 797170VWFA 4PROSITE-ProRule annotationAdd
BLAST
Domaini814 – 987174VWFA 5PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 1178174VWFA 6PROSITE-ProRule annotationAdd
BLAST
Domaini1194 – 1376183VWFA 7PROSITE-ProRule annotationAdd
BLAST
Domaini1395 – 144652Collagen-like 1Sequence analysisAdd
BLAST
Domaini1434 – 149057Collagen-like 2Sequence analysisAdd
BLAST
Domaini1464 – 152057Collagen-like 3Sequence analysisAdd
BLAST
Domaini1524 – 158057Collagen-like 4Sequence analysisAdd
BLAST
Domaini1579 – 162951Collagen-like 5Sequence analysisAdd
BLAST
Domaini1674 – 172956Collagen-like 6Sequence analysisAdd
BLAST
Domaini1758 – 1965208VWFA 8PROSITE-ProRule annotationAdd
BLAST
Domaini1963 – 2154192VWFA 9PROSITE-ProRule annotationAdd
BLAST
Domaini2291 – 2487197VWFA 10PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 13941376Nonhelical regionAdd
BLAST
Regioni1395 – 1728334Triple-helical regionAdd
BLAST
Regioni1729 – 2615887Nonhelical regionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1430 – 14323Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the type VI collagen family.Curated
Contains 6 collagen-like domains.Sequence analysis
Contains 10 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410XNMM. LUCA.
GeneTreeiENSGT00760000119000.
HOVERGENiHBG107743.
InParanoidiA8TX70.
KOiK06238.
OMAiKCFPNAC.
OrthoDBiEOG7C2R09.
PhylomeDBiA8TX70.

Family and domain databases

Gene3Di3.40.50.410. 9 hits.
InterProiIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00092. VWA. 9 hits.
[Graphical view]
SMARTiSM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 10 hits.
PROSITEiPS50234. VWFA. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8TX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILLIIFVL IIWTETLADQ SPGPGPVYAD VVFLVDSSDH LGPKSFPFVK
60 70 80 90 100
TFINKMINSL PIEANKYRVA LAQYSDEFHS EFHLSTFKGR SPMLNHLKKN
110 120 130 140 150
FQFIGGSLQI GKALQEAHRT YFSAPINGRD RKQFPPILVV LASAESEDEV
160 170 180 190 200
EEASKALQKD GVKIISVGVQ KASEENLKAM ATSHFHFNLR TIRDLSTFSQ
210 220 230 240 250
NMTQIIKDVT KYKEGAVDAD MQVHFPISCQ KDSLADLVFL VDESLGTGGN
260 270 280 290 300
LRHLQTFLEN ITSSMDVKEN CMRLGLMSYS NSAKTISFLK SSTTQSEFQQ
310 320 330 340 350
QIKNLSIQVG KSNTGAAIDQ MRRDGFSESY GSRRAQGVPQ IAVLVTHRPS
360 370 380 390 400
DDEVHDAALN LRLEDVNVFA LSIQGANNTQ LEEIVSYPPE QTISTLKSYA
410 420 430 440 450
DLETYSTKFL KKLQNEIWSQ ISTYAEQRNL DKTGCVDTKE ADIHFLIDGS
460 470 480 490 500
SSIQEKQFEQ IKRFMLEVTE MFSIGPDKVR VGVVQYSDDT EVEFYITDYS
510 520 530 540 550
NDIDLRKAIF NIKQLTGGTY TGKALDYILQ IIKNGMKDRM SKVPCYLIVL
560 570 580 590 600
TDGMSTDRVV EPAKRLRAEQ ITVHAVGIGA ANKIELQEIA GKEERVSFGQ
610 620 630 640 650
NFDALKSIKN EVVREICAEK GCEDMKADIM FLVDSSWSIG NENFRKMKIF
660 670 680 690 700
MKNLLTKIQI GADKTQIGVV QFSDKTKEEF QLNRYFTQQE ISDAIDRMSL
710 720 730 740 750
INEGTLTGKA LNFVGQYFTH SKGARLGAKK FLILITDGVA QDDVRDPARI
760 770 780 790 800
LRGKDVTIFS VGVYNANRSQ LEEISGDSSL VFHVENFDHL KALERKLIFR
810 820 830 840 850
VCALHDCKRI TLLDVVFVLD HSGSIKKQYQ DHMINLTIHL VKKADVGRDR
860 870 880 890 900
VQFGALKYSD QPNILFYLNT YSNRSAIIEN LRKRRDTGGN TYTAKALKHA
910 920 930 940 950
NALFTEEHGS RIKQNVKQML IVITDGESHD HDQLNDTALE LRNKGITIFA
960 970 980 990 1000
VGVGKANQKE LEGMAGNKNN TIYVDNFDKL KDVFTLVQER MCTEAPEVCH
1010 1020 1030 1040 1050
LQEADVIFLC DGSDRVSNSD FVTMTTFLSD LIDNFDIQSQ RMKIGMAQFG
1060 1070 1080 1090 1100
SNYQSIIELK NSLTKTQWKT QIQNVSKSGG FPRIDFALKK VSNMFNLHAG
1110 1120 1130 1140 1150
GRRNAGVPQT LVVITSGDPR YDVADAVKTL KDLGICVLVL GIGDVYKEHL
1160 1170 1180 1190 1200
LPITGNSEKI ITFQDFDKLK NVDVKKRIIR EICQSCGKTN CFMDIVVGFD
1210 1220 1230 1240 1250
ISTHVQGQPL FQGHPQLESY LPGILEDISS IKGVSCGAGT EAQVSLAFKV
1260 1270 1280 1290 1300
NSDQGFPAKF QIYQKAVFDS LLQVNVSGPT HLNAQFLRSL WDTFKDKSAS
1310 1320 1330 1340 1350
RGQVLLIFSD GLQSESNIML ENQSDRLREA GLDALLVVSL NTTAHHEFSS
1360 1370 1380 1390 1400
FEFGKRFDYR THLTIGMREL GKKLSQYLGN IAERTCCCTF CKCPGIPGPH
1410 1420 1430 1440 1450
GTRGLQAMKG SQGLKGSRGH RGEDGNPGVR GDTGPQGDKG IAGCPGAWGQ
1460 1470 1480 1490 1500
KGLKGFSGPK GGHGDDGIDG LDGEEGCHGF PGIKGEKGDP GSQGSPGSRG
1510 1520 1530 1540 1550
APGQYGEKGF PGDPGNPGQN NNIKGQKGSK GEQGRQGRSG QKGVQGSPSS
1560 1570 1580 1590 1600
RGSRGREGQR GLRGVSGEPG NPGPTGTLGA EGLQGPQGSQ GNPGRKGEKG
1610 1620 1630 1640 1650
SQGQKGPQGS PGLMGAKGST GRPGLLGKKG EPGLPGDLGP VGQTGQRGRQ
1660 1670 1680 1690 1700
GDSGIPGYGQ MGRKGVKGPR GFPGDAGQKG DIGNPGIPGG PGPKGFRGLA
1710 1720 1730 1740 1750
LTVGLKGEEG SRGLPGPPGQ RGIKGMAGQP VYSQCDLIRF LREHSPCWKE
1760 1770 1780 1790 1800
KCPAYPTELV FALDNSYDVT EESFNKTRDI ITSIVNDLNI RENNCPVGAR
1810 1820 1830 1840 1850
VAMVSYNSGT SYLIRWSDYN RKKQLLQQLS QIKYQDTTEP RDVGNAMRFV
1860 1870 1880 1890 1900
TRNVFKRTYA GANVRRVAVF FSNGQTASRS SIITATMEFS ALDISPTVFA
1910 1920 1930 1940 1950
FDERVFLEAF GFDNTGTFQV IPVPPNGENQ TLERLRRCAL CYDKCFPNAC
1960 1970 1980 1990 2000
IREAFLPEDS YMDVVFLIDN SRNIAKDEFK AVKALVSSVI DNFNIASDPL
2010 2020 2030 2040 2050
ISDSGDRIAL LSYSPWESSR RKMGTVKTEF DFITYDNQLL MKNHIQTSFQ
2060 2070 2080 2090 2100
QLNGEATIGR ALLWTTENLF PETPYLRKHK VIFVVSAGEN YERKEFVKMM
2110 2120 2130 2140 2150
ALRAKCQGYV IFVISLGSTR KDDMEELASY PLDQHLIQLG RIHKPDLNYI
2160 2170 2180 2190 2200
AKFLKPFLYS VRRGFNQYPP PMLEDACRLI NLGGENIQND GFQFVTELQE
2210 2220 2230 2240 2250
DFLGGNGFIG QELNSGRESP FVKTEDNGSD YLVYLPSQMF EPQKLMINYE
2260 2270 2280 2290 2300
KDQKSAEIAS LTSGHENYGR KEEPDHTYEP GDVSLQEYYM DVAFLIDASQ
2310 2320 2330 2340 2350
RVGSDEFKEV KAFITSVLDY FHIAPTPLTS TLGDRVAVLS YSPPGYMPNT
2360 2370 2380 2390 2400
EECPVYLEFD LVTYNSIHQM KHHLQDSQQL NGDVFIGHAL QWTIDNVFVG
2410 2420 2430 2440 2450
TPNLRKNKVI FVISAGETNS LDKDVLRNVS LRAKCQGYSI FVFSFGPKHN
2460 2470 2480 2490 2500
DKELEELASH PLDHHLVQLG RTHKPDWNYI IKFVKPFVHL IRRAINKYPT
2510 2520 2530 2540 2550
EDMKATCVNM TSPNPENGGT ENTVLLLPGI YEIKTENGDL FDEFDSQAQH
2560 2570 2580 2590 2600
LLVLGNNHSS GSETATDLMQ KLYLLFSTEK LAMKDKEKAH LEEISALVVD
2610
KQQEKEDKEM EATDI
Length:2,615
Mass (Da):289,926
Last modified:January 15, 2008 - v1
Checksum:i745874018AC47EAF
GO
Isoform 2 (identifier: A8TX70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2526-2526: L → W
     2527-2615: Missing.

Note: No experimental confirmation available.
Show »
Length:2,526
Mass (Da):279,931
Checksum:i57BCAE5953E94AB6
GO

Sequence cautioni

The sequence BAC04092.1 differs from that shown. Reason: Frameshift at position 2591. Curated
The sequence BAC04092.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85681.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2482 – 24821K → R in BAC04092 (PubMed:14702039).Curated
Sequence conflicti2512 – 25121S → P in BAC04092 (PubMed:14702039).Curated
Sequence conflicti2560 – 25601S → N in CAP20002 (PubMed:18276594).Curated
Sequence conflicti2560 – 25601S → N in CAP20003 (PubMed:18276594).Curated
Sequence conflicti2560 – 25601S → N in BAC04092 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti455 – 4551E → K.1 Publication
Corresponds to variant rs1453241 [ dbSNP | Ensembl ].
VAR_059234
Natural varianti641 – 6411N → H.
Corresponds to variant rs9882852 [ dbSNP | Ensembl ].
VAR_059235
Natural varianti805 – 8051H → R.
Corresponds to variant rs16827168 [ dbSNP | Ensembl ].
VAR_059236
Natural varianti982 – 9821D → G.
Corresponds to variant rs11917356 [ dbSNP | Ensembl ].
VAR_059237
Natural varianti1114 – 11141I → M.
Corresponds to variant rs1353613 [ dbSNP | Ensembl ].
VAR_059238
Natural varianti1280 – 12801T → P.1 Publication
Corresponds to variant rs12488457 [ dbSNP | Ensembl ].
VAR_059239
Natural varianti1477 – 14771C → S.
Corresponds to variant rs1497312 [ dbSNP | Ensembl ].
VAR_059240
Natural varianti1589 – 15891S → P.
Corresponds to variant rs16827497 [ dbSNP | Ensembl ].
VAR_059241
Natural varianti2175 – 21751D → N.
Corresponds to variant rs60021408 [ dbSNP | Ensembl ].
VAR_061119
Natural varianti2188 – 21881Q → R.2 Publications
Corresponds to variant rs9883988 [ dbSNP | Ensembl ].
VAR_043607
Natural varianti2205 – 22051G → D.2 Publications
Corresponds to variant rs819085 [ dbSNP | Ensembl ].
VAR_043608

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2526 – 25261L → W in isoform 2. 1 PublicationVSP_033912
Alternative sequencei2527 – 261589Missing in isoform 2. 1 PublicationVSP_033913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU085556 mRNA. Translation: ABW81241.1.
AM906078 mRNA. Translation: CAP19997.1.
AM906079 mRNA. Translation: CAP19998.1.
AM906080 mRNA. Translation: CAP19999.1.
AM906081 mRNA. Translation: CAP20000.1.
AM906082 mRNA. Translation: CAP20001.1.
AM906083 mRNA. Translation: CAP20002.1.
AM906084 mRNA. Translation: CAP20003.1.
AC093004 Genomic DNA. No translation available.
AC117398 Genomic DNA. No translation available.
AK093199 mRNA. Translation: BAC04092.1. Sequence problems.
AK123718 mRNA. Translation: BAC85681.1. Different initiation.
RefSeqiNP_001265227.1. NM_001278298.1.
NP_694996.5. NM_153264.6. [A8TX70-2]
UniGeneiHs.205403.

Genome annotation databases

EnsembliENST00000312481; ENSP00000309762; ENSG00000172752. [A8TX70-1]
GeneIDi256076.
KEGGihsa:256076.
UCSCiuc062ntw.1. human. [A8TX70-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU085556 mRNA. Translation: ABW81241.1.
AM906078 mRNA. Translation: CAP19997.1.
AM906079 mRNA. Translation: CAP19998.1.
AM906080 mRNA. Translation: CAP19999.1.
AM906081 mRNA. Translation: CAP20000.1.
AM906082 mRNA. Translation: CAP20001.1.
AM906083 mRNA. Translation: CAP20002.1.
AM906084 mRNA. Translation: CAP20003.1.
AC093004 Genomic DNA. No translation available.
AC117398 Genomic DNA. No translation available.
AK093199 mRNA. Translation: BAC04092.1. Sequence problems.
AK123718 mRNA. Translation: BAC85681.1. Different initiation.
RefSeqiNP_001265227.1. NM_001278298.1.
NP_694996.5. NM_153264.6. [A8TX70-2]
UniGeneiHs.205403.

3D structure databases

ProteinModelPortaliA8TX70.
SMRiA8TX70. Positions 30-204, 232-1332, 1400-1425, 1433-1461, 1566-1594, 1632-1657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265379.

Chemistry

ChEMBLiCHEMBL2364188.

PTM databases

iPTMnetiA8TX70.
PhosphoSiteiA8TX70.

Proteomic databases

PaxDbiA8TX70.
PRIDEiA8TX70.

Protocols and materials databases

DNASUi256076.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312481; ENSP00000309762; ENSG00000172752. [A8TX70-1]
GeneIDi256076.
KEGGihsa:256076.
UCSCiuc062ntw.1. human. [A8TX70-1]

Organism-specific databases

CTDi256076.
GeneCardsiCOL6A5.
H-InvDBHIX0003678.
HGNCiHGNC:26674. COL6A5.
HPAiHPA043138.
MIMi611916. gene.
neXtProtiNX_A8TX70.
PharmGKBiPA165696956.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410XNMM. LUCA.
GeneTreeiENSGT00760000119000.
HOVERGENiHBG107743.
InParanoidiA8TX70.
KOiK06238.
OMAiKCFPNAC.
OrthoDBiEOG7C2R09.
PhylomeDBiA8TX70.

Enzyme and pathway databases

ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-186797. Signaling by PDGF.
R-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-419037. NCAM1 interactions.

Miscellaneous databases

GenomeRNAii256076.
NextBioi92704.
PROiA8TX70.
SOURCEiSearch...

Gene expression databases

BgeeiA8TX70.
ExpressionAtlasiA8TX70. baseline and differential.
GenevisibleiA8TX70. HS.

Family and domain databases

Gene3Di3.40.50.410. 9 hits.
InterProiIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00092. VWA. 9 hits.
[Graphical view]
SMARTiSM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 10 hits.
PROSITEiPS50234. VWFA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN ATOPIC DERMATITIS.
    Tissue: Skin.
  2. "Three novel collagen VI chains with high homology to the alpha 3 chain."
    Gara S.K., Grumati P., Urciuolo A., Bonaldo P., Kobbe B., Koch M., Paulsson M., Wagener R.
    J. Biol. Chem. 283:10658-10670(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS LYS-455; PRO-1280; ARG-2188 AND ASP-2205.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1900-2615 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2096-2615 (ISOFORM 1), VARIANTS ARG-2188 AND ASP-2205.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiCO6A5_HUMAN
AccessioniPrimary (citable) accession number: A8TX70
Secondary accession number(s): A9J6L2
, A9J6L4, A9J6L6, A9J6L7, A9J6M0, A9J6M1, A9J6M2, B5MEA7, Q6ZW26, Q8NA36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.