A8QXS1 (A8QXS1_TREOR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Melanocortin 4 receptor EMBL ABW94938.1

Gene names

Name:

MC4R EMBL ABW94938.1

Organism

Tremarctos ornatus (Spectacled bear) EMBL ABW94938.1

Taxonomic identifier

9638 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Ursidae › Tremarctos

Protein attributes

Sequence length	224 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein By similarity SAAS SAAS001671.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Cell membrane SAAS SAAS001671 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS001671
Molecular function	G-protein coupled receptor SAAS SAAS001671 RuleBase RU000688 Receptor Transducer
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	melanocortin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ABW94938.1
	Non-terminal residue	224	1	EMBL ABW94938.1

Sequences

	Sequence		Length	Mass (Da)
	A8QXS1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 38BF4BA7ACBFABB8	FASTA	224	24,909
	10 20 30 40 50 60 KNLHSPMYFF ICSLAVADML VSVSNGSETI VITLLNSTDT DAQSFTVNID NVIDSVICSS 70 80 90 100 110 120 LLASICSLLS IAVDRYFTIF YALQYHNIMT VRRVGIIISC IWAACTVSGI LFIIYSDSSA 130 140 150 160 170 180 VIICLITMFF TMLALMASLY VHMFLMARLH IKRIAVLPGT GTIRQGANMK GAITLTILIG 190 200 210 220 VFVVCWAPFF LHLIFYISCP QNPYCVCFMS HFNLYLILIM CNSI

References

[1]	"Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor." Staubert C., Tarnow P., Brumm H., Pitra C., Gudermann T., Gruters A., Schoneberg T., Biebermann H., Rompler H. Endocrinology 148:4642-4648(2007) [PubMed: 17628007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF384250 Genomic DNA. Translation: ABW94938.1.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108148.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000155. Mcort_rcpt_4. IPR001908. Melancort_rcpt. IPR001671. Melcrt_ACTH_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00534. MCRFAMILY. PR00535. MELNOCORTINR. PR01062. MELNOCORTN4R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8QXS1_TREOR

Accession

Primary (citable) accession number: A8QXS1

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	March 8, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)