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Protein

Malto-oligosyltrehalose trehalohydrolase

Gene

treZ

Organism
Actinoplanes sp. SN223/29
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.UniRule annotation

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei244NucleophileUniRule annotation1
Active sitei281Proton donorUniRule annotation1
Sitei377Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00299.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Malto-oligosyltrehalose trehalohydrolaseUniRule annotation (EC:3.2.1.141UniRule annotation)
Short name:
MTHaseUniRule annotation
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolaseUniRule annotation
Maltooligosyl trehalose trehalohydrolaseUniRule annotation
Gene namesi
Name:treZImported
OrganismiActinoplanes sp. SN223/29Imported
Taxonomic identifieri442459 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliA8QX08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 496AamyInterPro annotationAdd BLAST398

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR022567. DUF3459.
IPR006047. Glyco_hydro_13_cat_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012768. Trehalose_TreZ.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
PIRSFiPIRSF006337. Trehalose_TreZ. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR02402. trehalose_TreZ. 1 hit.

Sequencei

Sequence statusi: Complete.

A8QX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFEVWAPE KSPKLRLDDQ EHEMEPGDGG WWRLDVPTAG PGTDYAYVLE
60 70 80 90 100
DVAAPVPDPR SAWQPQGVHG PSRVYDHAAF TWTDQRWPGR QLPGAVLYEL
110 120 130 140 150
HIGTFTPAGT FDAAIERLDH LVDLGVDLVE LLPVNAFNGE HNWGYDGVCW
160 170 180 190 200
YAPHEAYGGP DGLKRFVDAA HAKGLGVVLD VVYNHFGPSG AYAPMFAPYL
210 220 230 240 250
SAGQNTWGSS LNLDGPDSGE VRRYIADSVL MWLRDYHIDG LRLDAVHALH
260 270 280 290 300
DEGAVHLLEQ LAVEVESLST ALRRPLTLIA ESDLNDPKLI TPREAGGYGL
310 320 330 340 350
HAQWDDDVHH ALHSLLTGER QGYYGDFGSL DCLRTVLEGA FYHAGTWSSF
360 370 380 390 400
RNRRHGRPVD RQRTAGHRFV AFLQNHDQIG NRAIGDRLTA TLSPGLLKVG
410 420 430 440 450
ATLLLTSPFT PMLFMGEEWA ASSPWQFFTS HPEPELAAAV QTGRRREFAR
460 470 480 490 500
HGWAEADVPD PQDPATFQRS KLDWSELGKP EHAEMLALYK KLIRLRREVP
510 520 530 540 550
DLTDPWLSEV EVWHGDQFVV IRRGRHAVAA NLAETPQTVS LRAVPSAVLL
560 570
ATADGVILER DRVVLPPESA VVVRTSR
Length:577
Mass (Da):64,098
Last modified:January 15, 2008 - v1
Checksum:iAB01264076EFE87A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF364111 Genomic DNA. Translation: ABV26726.1.

Similar proteinsi

Entry informationi

Entry nameiA8QX08_9ACTN
AccessioniPrimary (citable) accession number: A8QX08
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)