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A8QLH9

- A8QLH9_DANRE

UniProt

A8QLH9 - A8QLH9_DANRE

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Protein
Submitted name: Breast and ovarian cancer susceptibility protein 2
Gene
brca2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility protein 2Imported
Gene namesi
Name:brca2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-060510-3. brca2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099674.

Structurei

3D structure databases

ProteinModelPortaliA8QLH9.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG331296.
HOVERGENiHBG106730.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 9 hits.
PF09121. Tower. 1 hit.
[Graphical view]
PIRSFiPIRSF002397. BRCA2. 1 hit.
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEiPS50138. BRCA2_REPEAT. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8QLH9-1 [UniParc]FASTAAdd to Basket

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MFENFFHQID RELGPLNPDW FEELNKRASR DEGSAESSKA GENESIKAPE     50
TSALASQLFS TPRIFKQRHF PQSPDSIPNE KSQNEGANGE LSAFPWTESS 100
PCLFGSAKDS PKFDRSSEKP RDCFGLLDTP KRSLARSAKQ ISESLGAQIN 150
PDLSWTSSFN TPPSMTPTVI LPTTEDRVAS ASILKDKESI FVRKLFPSLS 200
KDSENATTLK QDVVTKSESI EADDLGEKTV CSPNESLDIS SLWKQRVPNA 250
IEDGDVRNTV QNVLDGAEDV LSIFFSNNTS ACRKIKSKER IRKRITNSSE 300
DVKSVFLTSE PEQKLKADAE TKSPSKNDDS IQWTPLSLSE TILTEGCSST 350
SLVDNNNTVA PSETNDGAIF KYTSESSQTC PQSVRLESSP EGTQCQKFLL 400
DKSSAFMLNK KPRKFVYQVS SSDMSTTLTG SKADLPKCLD QTLKEGPSVE 450
ELSVCLNKSS FTNENPIGDQ TQPQAVEQLS SEHLDHGLDM TQLSKAFAEE 500
FTQEIMAGGL LDMRVQSNQK VQVQPKAEPE PKNKDGNHTD ISNLADISVN 550
SPNKSTSITT FEISHDSGCP TTFSDLDRTT ASFADIGEYF PTFKTANNKF 600
ICIPTEAIVK AKASLDEAAG DGLAKTSNQT KPKHFHVTET MCKSVSRSIP 650
APRPPVRQSI PSNHASGVSV SDASKTDSPK RFKMNLLNCS LPQSDESDCK 700
TGSKTIITVS DAGLQTESLL KEKLGRSSES SKPIHQKADF ERSAERHAVF 750
DISSTQKPTA VDSSCDDLEE NGTLTASQKA DVTELCSLLE EANSQYEFTQ 800
YKSTNIGSHN RTTEKEWDPD ILNDIDFDDS FSCDVVKGKH PSKTNASSVN 850
TSDLISFRSD LKEKQNGTVA LSVTEESALV DGMRSILSKS SDNSHFHTFG 900
FKTAKGKAIS VSEKSLNKAK HFFEEDYKEA TFTGVINQEH FKTEPSVKTC 950
ISAENNNAQT KQDVSLSCEE VNAAHNMIHW QEAGNAGTEP NCLRDKTDVV 1000
CVDSNIHFGF STARGAKLKV SEKALEQARM FLNDVDSIGK SQTPKLVPRS 1050
SGKHDVSMQS TRLQKTKNLC RGETSIKISQ PDSGVANQIS NGADITTFNS 1100
ENVFQEQKSG NAAKEVCEKI SPSETSMPQP QQGYGFQTAS GKGVSVLPSA 1150
LKKTKAIFKD CDSNIDNLQS TNMEERKTKL DVEIVKQTNA LISNSKSVTF 1200
SDVEEFKTDL INNLDQEAPQ KEVCELKGLQ SEFSNLISSN GNCGFSTASG 1250
KKVSVSAEAL QRAKDVLFES VDGFSCANVY KKTNQVVDIQ LDSSSSGKHK 1300
GFCTAGGKKV AFSATGLQKA KNLFRGCEEE SLTTEQNCKG LSNVLMLACN 1350
GVSLIPEPGN SSGGNVGFST AGGRKMDISV TALQKANNLF KDCEEESLAS 1400
RSLAHQGFTT ASGKNVFVSE KALSEVRAVF AGCDETSFSL ELKKSSENNV 1450
GFSTAGGKKV TISDTSLQRT MNLFQDCEEE SLGSRSLKHQ GCKGFTTASG 1500
KNVTVSEKAL SEVRAVFAGC DEASFSHEPK NISGNKIGFS TTVEKMTTAL 1550
EMPNNNNNFK DCEEESLASR NLMHQACKGF TTASGKNVTV SETALNEVKA 1600
VFAGCDEATF DLEPKKSLGS NIGFSTAGGK KVTISSTALQ RAQTLFKDCE 1650
EEKEVFESEK APLPTKSFHA RSEDIVDGNL KFDQTNKKNP RLSTASGKVV 1700
SVTKVSLEET STFFREFDNQ NTATDNQLLL RDSSKHYPQH KDRQTKATLH 1750
PKAARNEPAH LDLHSLDFNS CTDTQQIYFE QEAMACTKAL LEDDDLIESA 1800
GLITSEDIDN KRRPSFSDVQ TIESVDQNRK RKRQVDGSSV ADSGQPPLKR 1850
QLLSEFDRTL HAKTSGLTPL KSCPNGTLKD RRVFKYNVHL KPYVTSPVLF 1900
PVNQQSNNIE EHCSTESVQK RCNSDHMGGV FNPPFQKNMN PPTSNSQDAS 1950
KVSSGIVLSF NVVNQEENPN SKEMDQIMAI SKSHCDRGKQ NCNEKNQDSK 2000
SKSSSSVQSI PLKIGNFDEK DMIALQESLQ LARDMQDMRL RKKKRQTIRP 2050
VPGSLYLAKT SGVSRKSLRD AVGCTCPSQY TQDELSQHGV HHKVLEITSE 2100
NAESFRFDCS DYFTCEHLME SGALQLADGG WLVPDSKGTV GKEEFFSALC 2150
GTPGVDPKLI SDVWVFNHYR WIIWKRASME RTFPYLIGGL CLTPEQVLLQ 2200
LKFRYDVEVD HSQRSALRRI MERDDTPAKT LVLCVCGIVQ TCQNPEKTMK 2250
DDKSPSAKME SCVIWLTDGW YSIKSLLDPP LSAMLNKGRL KIGDKIVTSG 2300
AELVGSQEAC PPLEAPESLM LKISANSTRR ARWDTKLGYY RDPRPIRLLL 2350
SSLYASGGLV SCVNLLVLRS YPTQWMEKKP NSVFIFRNDR AEDREARKHS 2400
NSKHKSLDLL ISKIQTQFEK EMEGKKKKRA QRKTFSRHEI ETLQDGDELY 2450
EAMEQDAAVE TRLSHKQMEA VSKYRCCREE KRQAELQERV QKAVMEAQEA 2500
EGGCPNRDVT PVWKLSVIDA TDMQSNCVYT LNIWRPTREL QGLLREGHRY 2550
RAYHLASSEG KKRSGVAHIQ LTATKKTLFQ DIEVSPEWLH QHFRARECVR 2600
FRELQNPHFS SPCGEVDIVG YIVSIEGKQG HCPVLHLVDE NFDLVTVRTY 2650
SSLEQLAVEE LVKPRALVAI CNLQVRVLSG PVPSLYAGEQ ALFSINPKES 2700
YLQEAMAHLK TFAQNYEQFF NLAEEKVSDV VPSGVLGSFQ SPRTPGVQPF 2750
PKMNGTVTPQ QKSSIFSPFT PLNRRTPAST SNSEVKDPKN LKRRRGLDYL 2800
SRIPSPPPLI PLKTRAPPCI NKTFNPPRKS VTPKPPQKEC SPASRPPAGE 2850
EKWVHDEELA MIDTQALVGG LMND 2874
Length:2,874
Mass (Da):317,416
Last modified:January 15, 2008 - v1
Checksum:i0D9F99FD015E74BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF088196 mRNA. Translation: ABO27625.1.
UniGeneiDr.108077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF088196 mRNA. Translation: ABO27625.1 .
UniGenei Dr.108077.

3D structure databases

ProteinModelPortali A8QLH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000099674.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-060510-3. brca2.

Phylogenomic databases

eggNOGi NOG331296.
HOVERGENi HBG106730.

Miscellaneous databases

NextBioi 20888361.

Family and domain databases

Gene3Di 2.40.50.140. 4 hits.
InterProi IPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower.
[Graphical view ]
PANTHERi PTHR11289. PTHR11289. 1 hit.
Pfami PF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 9 hits.
PF09121. Tower. 1 hit.
[Graphical view ]
PIRSFi PIRSF002397. BRCA2. 1 hit.
SUPFAMi SSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEi PS50138. BRCA2_REPEAT. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Zebrafish brca2/fancD1 Models Human Early Onset Breast Cancer Gene (BRCA2)."
    Titus T.A., Wilson C., Starks A.M., Yan Y.L., Frohnmayer J.D., Postlethwait J.H.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA8QLH9_DANRE
AccessioniPrimary (citable) accession number: A8QLH9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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