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Protein
Submitted name:

Breast and ovarian cancer susceptibility protein 2

Gene

brca2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility protein 2Imported
Gene namesi
Name:brca2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-060510-3. brca2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099674.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG331296.
HOVERGENiHBG106730.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 9 hits.
PF09121. Tower. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEiPS50138. BRCA2_REPEAT. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8QLH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFENFFHQID RELGPLNPDW FEELNKRASR DEGSAESSKA GENESIKAPE
60 70 80 90 100
TSALASQLFS TPRIFKQRHF PQSPDSIPNE KSQNEGANGE LSAFPWTESS
110 120 130 140 150
PCLFGSAKDS PKFDRSSEKP RDCFGLLDTP KRSLARSAKQ ISESLGAQIN
160 170 180 190 200
PDLSWTSSFN TPPSMTPTVI LPTTEDRVAS ASILKDKESI FVRKLFPSLS
210 220 230 240 250
KDSENATTLK QDVVTKSESI EADDLGEKTV CSPNESLDIS SLWKQRVPNA
260 270 280 290 300
IEDGDVRNTV QNVLDGAEDV LSIFFSNNTS ACRKIKSKER IRKRITNSSE
310 320 330 340 350
DVKSVFLTSE PEQKLKADAE TKSPSKNDDS IQWTPLSLSE TILTEGCSST
360 370 380 390 400
SLVDNNNTVA PSETNDGAIF KYTSESSQTC PQSVRLESSP EGTQCQKFLL
410 420 430 440 450
DKSSAFMLNK KPRKFVYQVS SSDMSTTLTG SKADLPKCLD QTLKEGPSVE
460 470 480 490 500
ELSVCLNKSS FTNENPIGDQ TQPQAVEQLS SEHLDHGLDM TQLSKAFAEE
510 520 530 540 550
FTQEIMAGGL LDMRVQSNQK VQVQPKAEPE PKNKDGNHTD ISNLADISVN
560 570 580 590 600
SPNKSTSITT FEISHDSGCP TTFSDLDRTT ASFADIGEYF PTFKTANNKF
610 620 630 640 650
ICIPTEAIVK AKASLDEAAG DGLAKTSNQT KPKHFHVTET MCKSVSRSIP
660 670 680 690 700
APRPPVRQSI PSNHASGVSV SDASKTDSPK RFKMNLLNCS LPQSDESDCK
710 720 730 740 750
TGSKTIITVS DAGLQTESLL KEKLGRSSES SKPIHQKADF ERSAERHAVF
760 770 780 790 800
DISSTQKPTA VDSSCDDLEE NGTLTASQKA DVTELCSLLE EANSQYEFTQ
810 820 830 840 850
YKSTNIGSHN RTTEKEWDPD ILNDIDFDDS FSCDVVKGKH PSKTNASSVN
860 870 880 890 900
TSDLISFRSD LKEKQNGTVA LSVTEESALV DGMRSILSKS SDNSHFHTFG
910 920 930 940 950
FKTAKGKAIS VSEKSLNKAK HFFEEDYKEA TFTGVINQEH FKTEPSVKTC
960 970 980 990 1000
ISAENNNAQT KQDVSLSCEE VNAAHNMIHW QEAGNAGTEP NCLRDKTDVV
1010 1020 1030 1040 1050
CVDSNIHFGF STARGAKLKV SEKALEQARM FLNDVDSIGK SQTPKLVPRS
1060 1070 1080 1090 1100
SGKHDVSMQS TRLQKTKNLC RGETSIKISQ PDSGVANQIS NGADITTFNS
1110 1120 1130 1140 1150
ENVFQEQKSG NAAKEVCEKI SPSETSMPQP QQGYGFQTAS GKGVSVLPSA
1160 1170 1180 1190 1200
LKKTKAIFKD CDSNIDNLQS TNMEERKTKL DVEIVKQTNA LISNSKSVTF
1210 1220 1230 1240 1250
SDVEEFKTDL INNLDQEAPQ KEVCELKGLQ SEFSNLISSN GNCGFSTASG
1260 1270 1280 1290 1300
KKVSVSAEAL QRAKDVLFES VDGFSCANVY KKTNQVVDIQ LDSSSSGKHK
1310 1320 1330 1340 1350
GFCTAGGKKV AFSATGLQKA KNLFRGCEEE SLTTEQNCKG LSNVLMLACN
1360 1370 1380 1390 1400
GVSLIPEPGN SSGGNVGFST AGGRKMDISV TALQKANNLF KDCEEESLAS
1410 1420 1430 1440 1450
RSLAHQGFTT ASGKNVFVSE KALSEVRAVF AGCDETSFSL ELKKSSENNV
1460 1470 1480 1490 1500
GFSTAGGKKV TISDTSLQRT MNLFQDCEEE SLGSRSLKHQ GCKGFTTASG
1510 1520 1530 1540 1550
KNVTVSEKAL SEVRAVFAGC DEASFSHEPK NISGNKIGFS TTVEKMTTAL
1560 1570 1580 1590 1600
EMPNNNNNFK DCEEESLASR NLMHQACKGF TTASGKNVTV SETALNEVKA
1610 1620 1630 1640 1650
VFAGCDEATF DLEPKKSLGS NIGFSTAGGK KVTISSTALQ RAQTLFKDCE
1660 1670 1680 1690 1700
EEKEVFESEK APLPTKSFHA RSEDIVDGNL KFDQTNKKNP RLSTASGKVV
1710 1720 1730 1740 1750
SVTKVSLEET STFFREFDNQ NTATDNQLLL RDSSKHYPQH KDRQTKATLH
1760 1770 1780 1790 1800
PKAARNEPAH LDLHSLDFNS CTDTQQIYFE QEAMACTKAL LEDDDLIESA
1810 1820 1830 1840 1850
GLITSEDIDN KRRPSFSDVQ TIESVDQNRK RKRQVDGSSV ADSGQPPLKR
1860 1870 1880 1890 1900
QLLSEFDRTL HAKTSGLTPL KSCPNGTLKD RRVFKYNVHL KPYVTSPVLF
1910 1920 1930 1940 1950
PVNQQSNNIE EHCSTESVQK RCNSDHMGGV FNPPFQKNMN PPTSNSQDAS
1960 1970 1980 1990 2000
KVSSGIVLSF NVVNQEENPN SKEMDQIMAI SKSHCDRGKQ NCNEKNQDSK
2010 2020 2030 2040 2050
SKSSSSVQSI PLKIGNFDEK DMIALQESLQ LARDMQDMRL RKKKRQTIRP
2060 2070 2080 2090 2100
VPGSLYLAKT SGVSRKSLRD AVGCTCPSQY TQDELSQHGV HHKVLEITSE
2110 2120 2130 2140 2150
NAESFRFDCS DYFTCEHLME SGALQLADGG WLVPDSKGTV GKEEFFSALC
2160 2170 2180 2190 2200
GTPGVDPKLI SDVWVFNHYR WIIWKRASME RTFPYLIGGL CLTPEQVLLQ
2210 2220 2230 2240 2250
LKFRYDVEVD HSQRSALRRI MERDDTPAKT LVLCVCGIVQ TCQNPEKTMK
2260 2270 2280 2290 2300
DDKSPSAKME SCVIWLTDGW YSIKSLLDPP LSAMLNKGRL KIGDKIVTSG
2310 2320 2330 2340 2350
AELVGSQEAC PPLEAPESLM LKISANSTRR ARWDTKLGYY RDPRPIRLLL
2360 2370 2380 2390 2400
SSLYASGGLV SCVNLLVLRS YPTQWMEKKP NSVFIFRNDR AEDREARKHS
2410 2420 2430 2440 2450
NSKHKSLDLL ISKIQTQFEK EMEGKKKKRA QRKTFSRHEI ETLQDGDELY
2460 2470 2480 2490 2500
EAMEQDAAVE TRLSHKQMEA VSKYRCCREE KRQAELQERV QKAVMEAQEA
2510 2520 2530 2540 2550
EGGCPNRDVT PVWKLSVIDA TDMQSNCVYT LNIWRPTREL QGLLREGHRY
2560 2570 2580 2590 2600
RAYHLASSEG KKRSGVAHIQ LTATKKTLFQ DIEVSPEWLH QHFRARECVR
2610 2620 2630 2640 2650
FRELQNPHFS SPCGEVDIVG YIVSIEGKQG HCPVLHLVDE NFDLVTVRTY
2660 2670 2680 2690 2700
SSLEQLAVEE LVKPRALVAI CNLQVRVLSG PVPSLYAGEQ ALFSINPKES
2710 2720 2730 2740 2750
YLQEAMAHLK TFAQNYEQFF NLAEEKVSDV VPSGVLGSFQ SPRTPGVQPF
2760 2770 2780 2790 2800
PKMNGTVTPQ QKSSIFSPFT PLNRRTPAST SNSEVKDPKN LKRRRGLDYL
2810 2820 2830 2840 2850
SRIPSPPPLI PLKTRAPPCI NKTFNPPRKS VTPKPPQKEC SPASRPPAGE
2860 2870
EKWVHDEELA MIDTQALVGG LMND
Length:2,874
Mass (Da):317,416
Last modified:January 14, 2008 - v1
Checksum:i0D9F99FD015E74BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF088196 mRNA. Translation: ABO27625.1.
UniGeneiDr.108077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF088196 mRNA. Translation: ABO27625.1.
UniGeneiDr.108077.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-060510-3. brca2.

Phylogenomic databases

eggNOGiNOG331296.
HOVERGENiHBG106730.

Miscellaneous databases

NextBioi20888361.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR015525. BRCA2.
IPR015252. BRCA2_hlx.
IPR015187. BRCA2_OB_1.
IPR015188. BRCA2_OB_3.
IPR002093. BRCA2_repeat.
IPR012340. NA-bd_OB-fold.
IPR015205. Tower.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.
PfamiPF09169. BRCA-2_helical. 1 hit.
PF09103. BRCA-2_OB1. 1 hit.
PF09104. BRCA-2_OB3. 1 hit.
PF00634. BRCA2. 9 hits.
PF09121. Tower. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
SSF81872. SSF81872. 1 hit.
PROSITEiPS50138. BRCA2_REPEAT. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Zebrafish brca2/fancD1 Models Human Early Onset Breast Cancer Gene (BRCA2)."
    Titus T.A., Wilson C., Starks A.M., Yan Y.L., Frohnmayer J.D., Postlethwait J.H.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA8QLH9_DANRE
AccessioniPrimary (citable) accession number: A8QLH9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 14, 2008
Last sequence update: January 14, 2008
Last modified: March 31, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.