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A8QLH9

- A8QLH9_DANRE

UniProt

A8QLH9 - A8QLH9_DANRE

Protein
Submitted name:

Breast and ovarian cancer susceptibility protein 2

Gene

brca2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. double-strand break repair via homologous recombination Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Breast and ovarian cancer susceptibility protein 2Imported
    Gene namesi
    Name:brca2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-060510-3. brca2.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000099674.

    Structurei

    3D structure databases

    ProteinModelPortaliA8QLH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG331296.
    HOVERGENiHBG106730.

    Family and domain databases

    Gene3Di2.40.50.140. 4 hits.
    InterProiIPR015525. BRCA2.
    IPR015252. BRCA2_hlx.
    IPR015187. BRCA2_OB_1.
    IPR015188. BRCA2_OB_3.
    IPR002093. BRCA2_repeat.
    IPR012340. NA-bd_OB-fold.
    IPR015205. Tower.
    [Graphical view]
    PANTHERiPTHR11289. PTHR11289. 1 hit.
    PfamiPF09169. BRCA-2_helical. 1 hit.
    PF09103. BRCA-2_OB1. 1 hit.
    PF09104. BRCA-2_OB3. 1 hit.
    PF00634. BRCA2. 9 hits.
    PF09121. Tower. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002397. BRCA2. 1 hit.
    SUPFAMiSSF50249. SSF50249. 4 hits.
    SSF81872. SSF81872. 1 hit.
    PROSITEiPS50138. BRCA2_REPEAT. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8QLH9-1 [UniParc]FASTAAdd to Basket

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    MFENFFHQID RELGPLNPDW FEELNKRASR DEGSAESSKA GENESIKAPE     50
    TSALASQLFS TPRIFKQRHF PQSPDSIPNE KSQNEGANGE LSAFPWTESS 100
    PCLFGSAKDS PKFDRSSEKP RDCFGLLDTP KRSLARSAKQ ISESLGAQIN 150
    PDLSWTSSFN TPPSMTPTVI LPTTEDRVAS ASILKDKESI FVRKLFPSLS 200
    KDSENATTLK QDVVTKSESI EADDLGEKTV CSPNESLDIS SLWKQRVPNA 250
    IEDGDVRNTV QNVLDGAEDV LSIFFSNNTS ACRKIKSKER IRKRITNSSE 300
    DVKSVFLTSE PEQKLKADAE TKSPSKNDDS IQWTPLSLSE TILTEGCSST 350
    SLVDNNNTVA PSETNDGAIF KYTSESSQTC PQSVRLESSP EGTQCQKFLL 400
    DKSSAFMLNK KPRKFVYQVS SSDMSTTLTG SKADLPKCLD QTLKEGPSVE 450
    ELSVCLNKSS FTNENPIGDQ TQPQAVEQLS SEHLDHGLDM TQLSKAFAEE 500
    FTQEIMAGGL LDMRVQSNQK VQVQPKAEPE PKNKDGNHTD ISNLADISVN 550
    SPNKSTSITT FEISHDSGCP TTFSDLDRTT ASFADIGEYF PTFKTANNKF 600
    ICIPTEAIVK AKASLDEAAG DGLAKTSNQT KPKHFHVTET MCKSVSRSIP 650
    APRPPVRQSI PSNHASGVSV SDASKTDSPK RFKMNLLNCS LPQSDESDCK 700
    TGSKTIITVS DAGLQTESLL KEKLGRSSES SKPIHQKADF ERSAERHAVF 750
    DISSTQKPTA VDSSCDDLEE NGTLTASQKA DVTELCSLLE EANSQYEFTQ 800
    YKSTNIGSHN RTTEKEWDPD ILNDIDFDDS FSCDVVKGKH PSKTNASSVN 850
    TSDLISFRSD LKEKQNGTVA LSVTEESALV DGMRSILSKS SDNSHFHTFG 900
    FKTAKGKAIS VSEKSLNKAK HFFEEDYKEA TFTGVINQEH FKTEPSVKTC 950
    ISAENNNAQT KQDVSLSCEE VNAAHNMIHW QEAGNAGTEP NCLRDKTDVV 1000
    CVDSNIHFGF STARGAKLKV SEKALEQARM FLNDVDSIGK SQTPKLVPRS 1050
    SGKHDVSMQS TRLQKTKNLC RGETSIKISQ PDSGVANQIS NGADITTFNS 1100
    ENVFQEQKSG NAAKEVCEKI SPSETSMPQP QQGYGFQTAS GKGVSVLPSA 1150
    LKKTKAIFKD CDSNIDNLQS TNMEERKTKL DVEIVKQTNA LISNSKSVTF 1200
    SDVEEFKTDL INNLDQEAPQ KEVCELKGLQ SEFSNLISSN GNCGFSTASG 1250
    KKVSVSAEAL QRAKDVLFES VDGFSCANVY KKTNQVVDIQ LDSSSSGKHK 1300
    GFCTAGGKKV AFSATGLQKA KNLFRGCEEE SLTTEQNCKG LSNVLMLACN 1350
    GVSLIPEPGN SSGGNVGFST AGGRKMDISV TALQKANNLF KDCEEESLAS 1400
    RSLAHQGFTT ASGKNVFVSE KALSEVRAVF AGCDETSFSL ELKKSSENNV 1450
    GFSTAGGKKV TISDTSLQRT MNLFQDCEEE SLGSRSLKHQ GCKGFTTASG 1500
    KNVTVSEKAL SEVRAVFAGC DEASFSHEPK NISGNKIGFS TTVEKMTTAL 1550
    EMPNNNNNFK DCEEESLASR NLMHQACKGF TTASGKNVTV SETALNEVKA 1600
    VFAGCDEATF DLEPKKSLGS NIGFSTAGGK KVTISSTALQ RAQTLFKDCE 1650
    EEKEVFESEK APLPTKSFHA RSEDIVDGNL KFDQTNKKNP RLSTASGKVV 1700
    SVTKVSLEET STFFREFDNQ NTATDNQLLL RDSSKHYPQH KDRQTKATLH 1750
    PKAARNEPAH LDLHSLDFNS CTDTQQIYFE QEAMACTKAL LEDDDLIESA 1800
    GLITSEDIDN KRRPSFSDVQ TIESVDQNRK RKRQVDGSSV ADSGQPPLKR 1850
    QLLSEFDRTL HAKTSGLTPL KSCPNGTLKD RRVFKYNVHL KPYVTSPVLF 1900
    PVNQQSNNIE EHCSTESVQK RCNSDHMGGV FNPPFQKNMN PPTSNSQDAS 1950
    KVSSGIVLSF NVVNQEENPN SKEMDQIMAI SKSHCDRGKQ NCNEKNQDSK 2000
    SKSSSSVQSI PLKIGNFDEK DMIALQESLQ LARDMQDMRL RKKKRQTIRP 2050
    VPGSLYLAKT SGVSRKSLRD AVGCTCPSQY TQDELSQHGV HHKVLEITSE 2100
    NAESFRFDCS DYFTCEHLME SGALQLADGG WLVPDSKGTV GKEEFFSALC 2150
    GTPGVDPKLI SDVWVFNHYR WIIWKRASME RTFPYLIGGL CLTPEQVLLQ 2200
    LKFRYDVEVD HSQRSALRRI MERDDTPAKT LVLCVCGIVQ TCQNPEKTMK 2250
    DDKSPSAKME SCVIWLTDGW YSIKSLLDPP LSAMLNKGRL KIGDKIVTSG 2300
    AELVGSQEAC PPLEAPESLM LKISANSTRR ARWDTKLGYY RDPRPIRLLL 2350
    SSLYASGGLV SCVNLLVLRS YPTQWMEKKP NSVFIFRNDR AEDREARKHS 2400
    NSKHKSLDLL ISKIQTQFEK EMEGKKKKRA QRKTFSRHEI ETLQDGDELY 2450
    EAMEQDAAVE TRLSHKQMEA VSKYRCCREE KRQAELQERV QKAVMEAQEA 2500
    EGGCPNRDVT PVWKLSVIDA TDMQSNCVYT LNIWRPTREL QGLLREGHRY 2550
    RAYHLASSEG KKRSGVAHIQ LTATKKTLFQ DIEVSPEWLH QHFRARECVR 2600
    FRELQNPHFS SPCGEVDIVG YIVSIEGKQG HCPVLHLVDE NFDLVTVRTY 2650
    SSLEQLAVEE LVKPRALVAI CNLQVRVLSG PVPSLYAGEQ ALFSINPKES 2700
    YLQEAMAHLK TFAQNYEQFF NLAEEKVSDV VPSGVLGSFQ SPRTPGVQPF 2750
    PKMNGTVTPQ QKSSIFSPFT PLNRRTPAST SNSEVKDPKN LKRRRGLDYL 2800
    SRIPSPPPLI PLKTRAPPCI NKTFNPPRKS VTPKPPQKEC SPASRPPAGE 2850
    EKWVHDEELA MIDTQALVGG LMND 2874
    Length:2,874
    Mass (Da):317,416
    Last modified:January 15, 2008 - v1
    Checksum:i0D9F99FD015E74BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF088196 mRNA. Translation: ABO27625.1.
    UniGeneiDr.108077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF088196 mRNA. Translation: ABO27625.1 .
    UniGenei Dr.108077.

    3D structure databases

    ProteinModelPortali A8QLH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000099674.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-060510-3. brca2.

    Phylogenomic databases

    eggNOGi NOG331296.
    HOVERGENi HBG106730.

    Miscellaneous databases

    NextBioi 20888361.

    Family and domain databases

    Gene3Di 2.40.50.140. 4 hits.
    InterProi IPR015525. BRCA2.
    IPR015252. BRCA2_hlx.
    IPR015187. BRCA2_OB_1.
    IPR015188. BRCA2_OB_3.
    IPR002093. BRCA2_repeat.
    IPR012340. NA-bd_OB-fold.
    IPR015205. Tower.
    [Graphical view ]
    PANTHERi PTHR11289. PTHR11289. 1 hit.
    Pfami PF09169. BRCA-2_helical. 1 hit.
    PF09103. BRCA-2_OB1. 1 hit.
    PF09104. BRCA-2_OB3. 1 hit.
    PF00634. BRCA2. 9 hits.
    PF09121. Tower. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002397. BRCA2. 1 hit.
    SUPFAMi SSF50249. SSF50249. 4 hits.
    SSF81872. SSF81872. 1 hit.
    PROSITEi PS50138. BRCA2_REPEAT. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zebrafish brca2/fancD1 Models Human Early Onset Breast Cancer Gene (BRCA2)."
      Titus T.A., Wilson C., Starks A.M., Yan Y.L., Frohnmayer J.D., Postlethwait J.H.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA8QLH9_DANRE
    AccessioniPrimary (citable) accession number: A8QLH9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)