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Protein
Submitted name:

Cyclooxygenase 2

Gene
N/A
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cyclooxygenase pathway Source: InterPro
  2. inflammatory response Source: InterPro
  3. regulation of blood pressure Source: InterPro
  4. response to oxidative stress Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 2Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Structurei

3D structure databases

ProteinModelPortaliA8QIU4.
SMRiA8QIU4. Positions 18-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
KOiK11987.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8QIU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARALLLCA ALALCRAANP CCSNPCQNQG VCLSIGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLFLKPT PNTVHYKLTH FKGVWNIVNN IPFLQNIIMK
110 120 130 140 150
YVLTSRSHLI ESPPTYNVDY GYKSWEAFSN LSYYTRALPP VADDCPTPMG
160 170 180 190 200
VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTKGL GHGVDLSHVY GETLDRQHKL RLFKDGKMKY QIIDGEVYPP
260 270 280 290 300
TVKDTQVEMI YPPHVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL IMIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFVYNNSIL
410 420 430 440 450
LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN
460 470 480 490 500
EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTAFSVQD PQLTKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,981
Last modified:January 15, 2008 - v1
Checksum:i9C7F33774B419C9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF036473 mRNA. Translation: ABM65700.1.
RefSeqiNP_001103919.1. NM_001110449.1.

Genome annotation databases

GeneIDi100126581.
KEGGifca:100126581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF036473 mRNA. Translation: ABM65700.1.
RefSeqiNP_001103919.1. NM_001110449.1.

3D structure databases

ProteinModelPortaliA8QIU4.
SMRiA8QIU4. Positions 18-569.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100126581.
KEGGifca:100126581.

Organism-specific databases

CTDi5743.

Phylogenomic databases

HOVERGENiHBG000366.
KOiK11987.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of feline COX-2 and expression in feline mammary carcinomas."
    Sayasith K., Sirois J., Dore M.
    Vet. Pathol. 46:423-429(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA8QIU4_FELCA
AccessioniPrimary (citable) accession number: A8QIU4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.