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Protein

F-box/SPRY domain-containing protein 1

Gene

Bm1_56115

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses.By similarity

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
ORF Names:Bm1_56115
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
ProteomesiUP000006672: Unassembled WGS sequence

Subcellular locationi

Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299F-box/SPRY domain-containing protein 1PRO_0000383747Add
BLAST

Interactioni

Subunit structurei

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliA8QGZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9449F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini105 – 297193B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiA8QGZ7.
KOiK10319.
OMAiDNVLMHN.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8QGZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA
60 70 80 90 100
RLPHVVLLAV FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP
110 120 130 140 150
DEALNDFSLL SEIPSFKDKL RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV
160 170 180 190 200
AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT VACIGLATKH AALHCQGYVA
210 220 230 240 250
LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG ERIRMIVDCE
260 270 280 290
QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG
Length:299
Mass (Da):33,808
Last modified:January 15, 2008 - v1
Checksum:iAB356B81B76AB912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS239779 Genomic DNA. Translation: EDP28469.1.
RefSeqiXP_001902681.1. XM_001902646.1.

Genome annotation databases

EnsemblMetazoaiBm2404c; Bm2404c; Bm2404.
GeneIDi6106105.
KEGGibmy:Bm1_56115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS239779 Genomic DNA. Translation: EDP28469.1.
RefSeqiXP_001902681.1. XM_001902646.1.

3D structure databases

ProteinModelPortaliA8QGZ7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiBm2404c; Bm2404c; Bm2404.
GeneIDi6106105.
KEGGibmy:Bm1_56115.

Organism-specific databases

CTDi6106105.

Phylogenomic databases

InParanoidiA8QGZ7.
KOiK10319.
OMAiDNVLMHN.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Draft genome of the filarial nematode parasite Brugia malayi."
    Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.
    , Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L.
    Science 317:1756-1760(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFBSP1_BRUMA
AccessioniPrimary (citable) accession number: A8QGZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: January 7, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.