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Protein

F-box/SPRY domain-containing protein 1

Gene

Bm1_56115

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
ORF Names:Bm1_56115
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaSpiruromorphaFilarioideaOnchocercidaeBrugia
Proteomesi
  • UP000006672 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003837471 – 299F-box/SPRY domain-containing protein 1Add BLAST299

Proteomic databases

PRIDEiA8QGZ7

Interactioni

Subunit structurei

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA8QGZ7
SMRiA8QGZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 94F-boxPROSITE-ProRule annotationAdd BLAST49
Domaini105 – 297B30.2/SPRYPROSITE-ProRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated

Phylogenomic databases

InParanoidiA8QGZ7
KOiK10319
OMAiEIWWEGP
OrthoDBiEOG091G0DF0

Family and domain databases

CDDicd12907 SPRY_Fbox, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR003877 SPRY_dom
IPR035784 SPRY_FBXO45
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

A8QGZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA
60 70 80 90 100
RLPHVVLLAV FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP
110 120 130 140 150
DEALNDFSLL SEIPSFKDKL RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV
160 170 180 190 200
AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT VACIGLATKH AALHCQGYVA
210 220 230 240 250
LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG ERIRMIVDCE
260 270 280 290
QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG
Length:299
Mass (Da):33,808
Last modified:January 15, 2008 - v1
Checksum:iAB356B81B76AB912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS239779 Genomic DNA Translation: EDP28469.1
RefSeqiXP_001902681.1, XM_001902646.1

Genome annotation databases

EnsemblMetazoaiBm2404; Bm2404; WBGene00222665
GeneIDi6106105
KEGGibmy:Bm1_56115
WBParaSiteiBm2404; Bm2404; WBGene00222665

Similar proteinsi

Entry informationi

Entry nameiFBSP1_BRUMA
AccessioniPrimary (citable) accession number: A8QGZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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