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A8QGZ7 (FBSP1_BRUMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene names
ORF Names:Bm1_56115
OrganismBrugia malayi (Filarial nematode worm) [Complete proteome]
Taxonomic identifier6279 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex By similarity.

Subcellular location

Cell junctionsynapse By similarity.

Sequence similarities

Belongs to the FBXO45/Fsn family.

Contains 1 B30.2/SPRY domain.

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCell junction
Synapse
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299F-box/SPRY domain-containing protein 1
PRO_0000383747

Regions

Domain46 – 9449F-box
Domain105 – 297193B30.2/SPRY

Sequences

Sequence LengthMass (Da)Tools
A8QGZ7 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: AB356B81B76AB912

FASTA29933,808
        10         20         30         40         50         60 
MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA RLPHVVLLAV 

        70         80         90        100        110        120 
FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP DEALNDFSLL SEIPSFKDKL 

       130        140        150        160        170        180 
RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT 

       190        200        210        220        230        240 
VACIGLATKH AALHCQGYVA LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG 

       250        260        270        280        290 
ERIRMIVDCE QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS239779 Genomic DNA. Translation: EDP28469.1.
RefSeqXP_001902681.1. XM_001902646.1.

3D structure databases

ProteinModelPortalA8QGZ7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaBm2404c; Bm2404c; Bm2404.
GeneID6106105.
KEGGbmy:Bm1_56115.

Organism-specific databases

CTD6106105.

Phylogenomic databases

InParanoidA8QGZ7.
KOK10319.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFBSP1_BRUMA
AccessionPrimary (citable) accession number: A8QGZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways