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A8QGZ7

- FBSP1_BRUMA

UniProt

A8QGZ7 - FBSP1_BRUMA

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Protein

F-box/SPRY domain-containing protein 1

Gene
Bm1_56115
Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses By similarity.

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
ORF Names:Bm1_56115
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
ProteomesiUP000006672: Unassembled WGS sequence

Subcellular locationi

Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299F-box/SPRY domain-containing protein 1PRO_0000383747Add
BLAST

Interactioni

Subunit structurei

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliA8QGZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9449F-boxAdd
BLAST
Domaini105 – 297193B30.2/SPRYAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.
Contains 1 B30.2/SPRY domain.
Contains 1 F-box domain.

Phylogenomic databases

InParanoidiA8QGZ7.
KOiK10319.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8QGZ7-1 [UniParc]FASTAAdd to Basket

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MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA    50
RLPHVVLLAV FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP 100
DEALNDFSLL SEIPSFKDKL RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV 150
AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT VACIGLATKH AALHCQGYVA 200
LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG ERIRMIVDCE 250
QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG 299
Length:299
Mass (Da):33,808
Last modified:January 15, 2008 - v1
Checksum:iAB356B81B76AB912
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS239779 Genomic DNA. Translation: EDP28469.1.
RefSeqiXP_001902681.1. XM_001902646.1.

Genome annotation databases

EnsemblMetazoaiBm2404c; Bm2404c; Bm2404.
GeneIDi6106105.
KEGGibmy:Bm1_56115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS239779 Genomic DNA. Translation: EDP28469.1 .
RefSeqi XP_001902681.1. XM_001902646.1.

3D structure databases

ProteinModelPortali A8QGZ7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Bm2404c ; Bm2404c ; Bm2404 .
GeneIDi 6106105.
KEGGi bmy:Bm1_56115.

Organism-specific databases

CTDi 6106105.

Phylogenomic databases

InParanoidi A8QGZ7.
KOi K10319.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Draft genome of the filarial nematode parasite Brugia malayi."
    Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.
    , Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L.
    Science 317:1756-1760(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFBSP1_BRUMA
AccessioniPrimary (citable) accession number: A8QGZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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