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A8QGZ7

- FBSP1_BRUMA

UniProt

A8QGZ7 - FBSP1_BRUMA

Protein

F-box/SPRY domain-containing protein 1

Gene

Bm1_56115

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses.By similarity

    Pathwayi

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/SPRY domain-containing protein 1
    Alternative name(s):
    F-box synaptic protein 1
    Gene namesi
    ORF Names:Bm1_56115
    OrganismiBrugia malayi (Filarial nematode worm)
    Taxonomic identifieri6279 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
    ProteomesiUP000006672: Unassembled WGS sequence

    Subcellular locationi

    Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299F-box/SPRY domain-containing protein 1PRO_0000383747Add
    BLAST

    Interactioni

    Subunit structurei

    Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA8QGZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 9449F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini105 – 297193B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FBXO45/Fsn family.Curated
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    InParanoidiA8QGZ7.
    KOiK10319.

    Family and domain databases

    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8QGZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTEGDKFNQ TVVETDLEQA VDVACRNAQD CCHSKSFTCF TRRMRAVSAA    50
    RLPHVVLLAV FEYLNLKDLA RCMRVCKHWL TVLQYPDSFV WRRLARTVIP 100
    DEALNDFSLL SEIPSFKDKL RAFCYAWNPN DSSKNNYLRP NGFTVHRNPV 150
    AQSTDSVRGK IGVNSGIHAW EFTWEGPLGT VACIGLATKH AALHCQGYVA 200
    LLGSDDQSWG WNLVDNQLLH NSKPISPYPH INNPPKYQMG ERIRMIVDCE 250
    QHSMYFEKGS EFLGIAFSRL PPLKLFPAMC AVYGNTEVSM VYIGPPLLG 299
    Length:299
    Mass (Da):33,808
    Last modified:January 15, 2008 - v1
    Checksum:iAB356B81B76AB912
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS239779 Genomic DNA. Translation: EDP28469.1.
    RefSeqiXP_001902681.1. XM_001902646.1.

    Genome annotation databases

    EnsemblMetazoaiBm2404c; Bm2404c; Bm2404.
    GeneIDi6106105.
    KEGGibmy:Bm1_56115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS239779 Genomic DNA. Translation: EDP28469.1 .
    RefSeqi XP_001902681.1. XM_001902646.1.

    3D structure databases

    ProteinModelPortali A8QGZ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Bm2404c ; Bm2404c ; Bm2404 .
    GeneIDi 6106105.
    KEGGi bmy:Bm1_56115.

    Organism-specific databases

    CTDi 6106105.

    Phylogenomic databases

    InParanoidi A8QGZ7.
    KOi K10319.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Draft genome of the filarial nematode parasite Brugia malayi."
      Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.
      , Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L.
      Science 317:1756-1760(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFBSP1_BRUMA
    AccessioniPrimary (citable) accession number: A8QGZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3