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A8QB25

- PMIP_MALGO

UniProt

A8QB25 - PMIP_MALGO

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi581 – 5811Zinc; catalyticPROSITE-ProRule annotation
    Active sitei582 – 5821PROSITE-ProRule annotation
    Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi588 – 5881Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:MGL_3874
    OrganismiMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
    Taxonomic identifieri425265 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaExobasidiomycetesMalassezialesMalasseziaceaeMalassezia
    ProteomesiUP000008837: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 806777Mitochondrial intermediate peptidasePRO_0000338588Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA8QB25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8QB25-1 [UniParc]FASTAAdd to Basket

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    MLSRHLTVLR SACRVSHDLR VPSTQAVRKS AWSVCYSRRP LHISRSDAAS    50
    TAALDMGVAP AVEKDHEILK ELLDTRHSSG HVLSQGVPTG LFQIDHLRTP 100
    SDFLLLAQRT LIRCQLLVQR IARAIGNPSE LARVVRNLDR LSDMLCGVID 150
    MAELVRHAHP DQGWANAAND AYEYLCNYMN VLNTHTELYD ALRCVMETKD 200
    IYHSLSQEAQ AVAHIFMRDF EKSGIHLPPH ERNRFVELSD QIMILGRAFL 250
    QDMSTGTSDT IVEFPTDLLD GMDTSIFAQN LFRLRPSKSI PVVPGSWELH 300
    YISKYAPNPQ ARRLAYMISY TGRTQPVAVL EQLLHARYEL AKLTGKQSFA 350
    EMTLVDKMAG TPEHVLRFLR LLADAQRPVA QRMIAEFGQL KHALEGSSQV 400
    EIWDREYYAD AYLQRHHPSQ LAPLSPYLSL GSIFTGLSRL FYLLYGIHFR 450
    AAETLPGEVW HPDVLKLEVV DETESSVIGL IYCDLYTRDG KPPSAAHYTV 500
    RCSRRIDLDD THLDMELGAS ADLPPVADTE HLLGVKGATG FGRPGRFQQP 550
    VVVLMTDFAP PNIGHGGACL LRWHDVETLF HEMGHAIHSM IGRTEFHNVS 600
    GTRCATDFVE LPSILMEHFL TDPSVVALTA HHHRTGSPLP YVQLQKHLAT 650
    QRSLDALDTH QQILLASLDQ RYHSERAGAP TFSSSQELES LQADMGLFPP 700
    VSNATWQGQF GHLFGYGATY YSYLFDRAIA ARVWEQVFAK KPLSREAGER 750
    FKMEVLRHGG GKSPWEMLSR LLHEDKIADG NAGAMEAIGR WGLGQNQSNE 800
    TISAHL 806
    Length:806
    Mass (Da):90,373
    Last modified:June 10, 2008 - v2
    Checksum:iC7156509B4D06706
    GO

    Sequence cautioni

    The sequence EDP41872.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAYY01000015 Genomic DNA. Translation: EDP41872.1. Different initiation.
    RefSeqiXP_001729086.1. XM_001729034.1.

    Genome annotation databases

    GeneIDi5853393.
    KEGGimgl:MGL_3874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAYY01000015 Genomic DNA. Translation: EDP41872.1 . Different initiation.
    RefSeqi XP_001729086.1. XM_001729034.1.

    3D structure databases

    ProteinModelPortali A8QB25.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5853393.
    KEGGi mgl:MGL_3874.

    Phylogenomic databases

    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4612 / CBS 7966.

    Entry informationi

    Entry nameiPMIP_MALGO
    AccessioniPrimary (citable) accession number: A8QB25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3