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A8QB25

- PMIP_MALGO

UniProt

A8QB25 - PMIP_MALGO

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi581 – 5811Zinc; catalyticPROSITE-ProRule annotation
Active sitei582 – 5821PROSITE-ProRule annotation
Metal bindingi585 – 5851Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi588 – 5881Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:MGL_3874
OrganismiMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Taxonomic identifieri425265 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaMalasseziomycetesMalassezialesMalasseziaceaeMalassezia
ProteomesiUP000008837: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 806777Mitochondrial intermediate peptidasePRO_0000338588Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8QB25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiA8QB25.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8QB25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRHLTVLR SACRVSHDLR VPSTQAVRKS AWSVCYSRRP LHISRSDAAS
60 70 80 90 100
TAALDMGVAP AVEKDHEILK ELLDTRHSSG HVLSQGVPTG LFQIDHLRTP
110 120 130 140 150
SDFLLLAQRT LIRCQLLVQR IARAIGNPSE LARVVRNLDR LSDMLCGVID
160 170 180 190 200
MAELVRHAHP DQGWANAAND AYEYLCNYMN VLNTHTELYD ALRCVMETKD
210 220 230 240 250
IYHSLSQEAQ AVAHIFMRDF EKSGIHLPPH ERNRFVELSD QIMILGRAFL
260 270 280 290 300
QDMSTGTSDT IVEFPTDLLD GMDTSIFAQN LFRLRPSKSI PVVPGSWELH
310 320 330 340 350
YISKYAPNPQ ARRLAYMISY TGRTQPVAVL EQLLHARYEL AKLTGKQSFA
360 370 380 390 400
EMTLVDKMAG TPEHVLRFLR LLADAQRPVA QRMIAEFGQL KHALEGSSQV
410 420 430 440 450
EIWDREYYAD AYLQRHHPSQ LAPLSPYLSL GSIFTGLSRL FYLLYGIHFR
460 470 480 490 500
AAETLPGEVW HPDVLKLEVV DETESSVIGL IYCDLYTRDG KPPSAAHYTV
510 520 530 540 550
RCSRRIDLDD THLDMELGAS ADLPPVADTE HLLGVKGATG FGRPGRFQQP
560 570 580 590 600
VVVLMTDFAP PNIGHGGACL LRWHDVETLF HEMGHAIHSM IGRTEFHNVS
610 620 630 640 650
GTRCATDFVE LPSILMEHFL TDPSVVALTA HHHRTGSPLP YVQLQKHLAT
660 670 680 690 700
QRSLDALDTH QQILLASLDQ RYHSERAGAP TFSSSQELES LQADMGLFPP
710 720 730 740 750
VSNATWQGQF GHLFGYGATY YSYLFDRAIA ARVWEQVFAK KPLSREAGER
760 770 780 790 800
FKMEVLRHGG GKSPWEMLSR LLHEDKIADG NAGAMEAIGR WGLGQNQSNE

TISAHL
Length:806
Mass (Da):90,373
Last modified:June 10, 2008 - v2
Checksum:iC7156509B4D06706
GO

Sequence cautioni

The sequence EDP41872.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAYY01000015 Genomic DNA. Translation: EDP41872.1. Different initiation.
RefSeqiXP_001729086.1. XM_001729034.1.

Genome annotation databases

GeneIDi5853393.
KEGGimgl:MGL_3874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAYY01000015 Genomic DNA. Translation: EDP41872.1 . Different initiation.
RefSeqi XP_001729086.1. XM_001729034.1.

3D structure databases

ProteinModelPortali A8QB25.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5853393.
KEGGi mgl:MGL_3874.

Phylogenomic databases

InParanoidi A8QB25.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4612 / CBS 7966.

Entry informationi

Entry nameiPMIP_MALGO
AccessioniPrimary (citable) accession number: A8QB25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 26, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3