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A8QB25 (PMIP_MALGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial intermediate peptidase

Short name=MIP
EC=3.4.24.59
Alternative name(s):
Octapeptidyl aminopeptidase
Gene names
Name:OCT1
ORF Names:MGL_3874
OrganismMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus) [Complete proteome]
Taxonomic identifier425265 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaExobasidiomycetesMalassezialesMalasseziaceaeMalassezia

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activity

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactor

Binds 1 zinc ion By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peptidase M3 family.

Sequence caution

The sequence EDP41872.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 806777Mitochondrial intermediate peptidase
PRO_0000338588

Sites

Active site5821 By similarity
Metal binding5811Zinc; catalytic By similarity
Metal binding5851Zinc; catalytic By similarity
Metal binding5881Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
A8QB25 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: C7156509B4D06706

FASTA80690,373
        10         20         30         40         50         60 
MLSRHLTVLR SACRVSHDLR VPSTQAVRKS AWSVCYSRRP LHISRSDAAS TAALDMGVAP 

        70         80         90        100        110        120 
AVEKDHEILK ELLDTRHSSG HVLSQGVPTG LFQIDHLRTP SDFLLLAQRT LIRCQLLVQR 

       130        140        150        160        170        180 
IARAIGNPSE LARVVRNLDR LSDMLCGVID MAELVRHAHP DQGWANAAND AYEYLCNYMN 

       190        200        210        220        230        240 
VLNTHTELYD ALRCVMETKD IYHSLSQEAQ AVAHIFMRDF EKSGIHLPPH ERNRFVELSD 

       250        260        270        280        290        300 
QIMILGRAFL QDMSTGTSDT IVEFPTDLLD GMDTSIFAQN LFRLRPSKSI PVVPGSWELH 

       310        320        330        340        350        360 
YISKYAPNPQ ARRLAYMISY TGRTQPVAVL EQLLHARYEL AKLTGKQSFA EMTLVDKMAG 

       370        380        390        400        410        420 
TPEHVLRFLR LLADAQRPVA QRMIAEFGQL KHALEGSSQV EIWDREYYAD AYLQRHHPSQ 

       430        440        450        460        470        480 
LAPLSPYLSL GSIFTGLSRL FYLLYGIHFR AAETLPGEVW HPDVLKLEVV DETESSVIGL 

       490        500        510        520        530        540 
IYCDLYTRDG KPPSAAHYTV RCSRRIDLDD THLDMELGAS ADLPPVADTE HLLGVKGATG 

       550        560        570        580        590        600 
FGRPGRFQQP VVVLMTDFAP PNIGHGGACL LRWHDVETLF HEMGHAIHSM IGRTEFHNVS 

       610        620        630        640        650        660 
GTRCATDFVE LPSILMEHFL TDPSVVALTA HHHRTGSPLP YVQLQKHLAT QRSLDALDTH 

       670        680        690        700        710        720 
QQILLASLDQ RYHSERAGAP TFSSSQELES LQADMGLFPP VSNATWQGQF GHLFGYGATY 

       730        740        750        760        770        780 
YSYLFDRAIA ARVWEQVFAK KPLSREAGER FKMEVLRHGG GKSPWEMLSR LLHEDKIADG 

       790        800 
NAGAMEAIGR WGLGQNQSNE TISAHL 

« Hide

References

[1]"Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens."
Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E., Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M., Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T., Chu L. expand/collapse author list , Sears R., Yuan B., Dawson T.L. Jr.
Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4612 / CBS 7966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAYY01000015 Genomic DNA. Translation: EDP41872.1. Different initiation.
RefSeqXP_001729086.1. XM_001729034.1.

3D structure databases

ProteinModelPortalA8QB25.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM03.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5853393.
KEGGmgl:MGL_3874.

Phylogenomic databases

KOK01410.
OrthoDBEOG71GB4R.

Family and domain databases

Gene3D1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMIP_MALGO
AccessionPrimary (citable) accession number: A8QB25
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries