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A8QB25

- PMIP_MALGO

UniProt

A8QB25 - PMIP_MALGO

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, MGL_3874
Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi581 – 5811Zinc; catalytic By similarity
Active sitei582 – 5821 By similarity
Metal bindingi585 – 5851Zinc; catalytic By similarity
Metal bindingi588 – 5881Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:MGL_3874
OrganismiMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Taxonomic identifieri425265 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaExobasidiomycetesMalassezialesMalasseziaceaeMalassezia
ProteomesiUP000008837: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion Reviewed prediction
Add
BLAST
Chaini30 – 806777Mitochondrial intermediate peptidase
PRO_0000338588Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8QB25.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8QB25-1 [UniParc]FASTAAdd to Basket

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MLSRHLTVLR SACRVSHDLR VPSTQAVRKS AWSVCYSRRP LHISRSDAAS    50
TAALDMGVAP AVEKDHEILK ELLDTRHSSG HVLSQGVPTG LFQIDHLRTP 100
SDFLLLAQRT LIRCQLLVQR IARAIGNPSE LARVVRNLDR LSDMLCGVID 150
MAELVRHAHP DQGWANAAND AYEYLCNYMN VLNTHTELYD ALRCVMETKD 200
IYHSLSQEAQ AVAHIFMRDF EKSGIHLPPH ERNRFVELSD QIMILGRAFL 250
QDMSTGTSDT IVEFPTDLLD GMDTSIFAQN LFRLRPSKSI PVVPGSWELH 300
YISKYAPNPQ ARRLAYMISY TGRTQPVAVL EQLLHARYEL AKLTGKQSFA 350
EMTLVDKMAG TPEHVLRFLR LLADAQRPVA QRMIAEFGQL KHALEGSSQV 400
EIWDREYYAD AYLQRHHPSQ LAPLSPYLSL GSIFTGLSRL FYLLYGIHFR 450
AAETLPGEVW HPDVLKLEVV DETESSVIGL IYCDLYTRDG KPPSAAHYTV 500
RCSRRIDLDD THLDMELGAS ADLPPVADTE HLLGVKGATG FGRPGRFQQP 550
VVVLMTDFAP PNIGHGGACL LRWHDVETLF HEMGHAIHSM IGRTEFHNVS 600
GTRCATDFVE LPSILMEHFL TDPSVVALTA HHHRTGSPLP YVQLQKHLAT 650
QRSLDALDTH QQILLASLDQ RYHSERAGAP TFSSSQELES LQADMGLFPP 700
VSNATWQGQF GHLFGYGATY YSYLFDRAIA ARVWEQVFAK KPLSREAGER 750
FKMEVLRHGG GKSPWEMLSR LLHEDKIADG NAGAMEAIGR WGLGQNQSNE 800
TISAHL 806
Length:806
Mass (Da):90,373
Last modified:June 10, 2008 - v2
Checksum:iC7156509B4D06706
GO

Sequence cautioni

The sequence EDP41872.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAYY01000015 Genomic DNA. Translation: EDP41872.1. Different initiation.
RefSeqiXP_001729086.1. XM_001729034.1.

Genome annotation databases

GeneIDi5853393.
KEGGimgl:MGL_3874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAYY01000015 Genomic DNA. Translation: EDP41872.1 . Different initiation.
RefSeqi XP_001729086.1. XM_001729034.1.

3D structure databases

ProteinModelPortali A8QB25.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5853393.
KEGGi mgl:MGL_3874.

Phylogenomic databases

KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4612 / CBS 7966.

Entry informationi

Entry nameiPMIP_MALGO
AccessioniPrimary (citable) accession number: A8QB25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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