ID   A8Q4W0_MALGO            Unreviewed;       822 AA.
AC   A8Q4W0;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=MGL_2653 {ECO:0000313|EMBL:EDP43057.1};
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265 {ECO:0000313|EMBL:EDP43057.1, ECO:0000313|Proteomes:UP000008837};
RN   [1] {ECO:0000313|EMBL:EDP43057.1, ECO:0000313|Proteomes:UP000008837}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966 {ECO:0000313|Proteomes:UP000008837};
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., Deangelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L.Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDP43057.1}.
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DR   EMBL; AAYY01000009; EDP43057.1; -; Genomic_DNA.
DR   RefSeq; XP_001730271.1; XM_001730219.1.
DR   AlphaFoldDB; A8Q4W0; -.
DR   STRING; 425265.A8Q4W0; -.
DR   GeneID; 5854576; -.
DR   KEGG; mgl:MGL_2653; -.
DR   VEuPathDB; FungiDB:MGL_2653; -.
DR   InParanoid; A8Q4W0; -.
DR   OMA; NVVQSCF; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF182; CULLIN_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008837}.
FT   DOMAIN          439..668
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   822 AA;  94089 MW;  AB901BFE57ECE90A CRC64;
     MSSGAPRRVG ARHHKLRAPR THGLSVSVDE MWSRLSSAIA QIQHHNISKL SYEEHYRYAY
     NLILNQQGDM LYGGVRRQVH EHLVHQSDQR LVPLFLLSTE DAVAVTEALS SKGKRREDAA
     REEARVFAWL PGQADELLPS IPAGERFLGA VTDVWEDHCS CMSKIRDVLK YVDRVYVPNH
     HRAPIWDLGL ELFRDSVVRS ARVPCRANLI VAMLRQVYCE REGATVERRT MKAAADMLLS
     LSHDAHSSVY AQDFEPVFLA TTSQYYAAEA ARLLSVQQAT YYLQAVERRF ADERVRVEAC
     FSPATLAPLK DLVERHLLSE QLDAILDMED GGLVSLLDAD ARADIERMYR LFRLVPPGLD
     ALNKVLRMYV TNRGKTINET TLAGQDGAPS AEVALSWVNQ VLDAKNRLDG ILHTSFHSDK
     SCEAAINEAM DAFINMNVRA PEYISLFIDE HLRKGTRAAD DTTLEQMLDK TITIFRYIHE
     KDVFERYYKM HLTRRLLHNR SVSDDAERSM IAKLKVECGH GYVQKLQGML NDMKLSEEVL
     AAFHRAQERE QRQLPLQMNV HVLTATYWPI SSPTEPCTLP PALLEACESF EKFYGTRHRG
     RVLTWQPTLG TAEVRVRFKT RTHELVVSTY ALMVLLLFEH SDTLSYRDIR AATRMPDVDL
     QRTLQSLACA KYKVLQKEPK GRDVHETDLF SFHADFTCPL ARVKIAQIAA KVESPQERKE
     TTAKVEEERK NQVEACIVRI MKSRKTLAHN DLVHEVVHQL LPRFQPSPAL IKKRIESLLD
     RGSYMRLSLH EAFIRFACIL TRTHTPEYIE RTEARHVYQY VA
//