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Protein

Hexokinase

Gene

Bm10227

Organism
Brugia malayi (Filarial nematode worm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Bm10227Imported
ORF Names:BM_Bm10227Imported
OrganismiBrugia malayi (Filarial nematode worm)Imported
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
ProteomesiUP000026912 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

InParanoidiA8PW64.
OMAiTEWGSFA.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8PW64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNQFSIPD LKNPDADKVR LEIKKACEKF MLSDDNLMKV SKIMDDEMNR
60 70 80 90 100
GLRGESSCLK MLPSFVRAVP NGTERGDFLA LDLGGTNFRV LLIKLKGDVA
110 120 130 140 150
EMTGKVYRIP EEIMRGVGTA LFDHIGQCLA DFLEEHNLKE SKELPLGFTF
160 170 180 190 200
SFPVEQENLT AGKLINWTKG FNAKGVEGQD VVQFLRDACN RRKDISIDVV
210 220 230 240 250
ALLNDTVGTL MACAFKDNTC QIGVILGTGT NACYMEKLSN CPKFKKYGFD
260 270 280 290 300
RDKYPKEMII NIEWGAFGDN GCIDFLRTEF DRDVDGGSIN PGKHLFEKMI
310 320 330 340 350
SGMYLGEIVR LVLVKLAKEK MLFDGDYEAI SKPNCFPTKF VSDIEEFNFF
360 370 380 390 400
LFDIIYELQK GLGDLRRTLQ ILQQIGINKI SDSDCFHVAY VCEVVSTRAA
410 420 430 440 450
YLTAAGISCI LTRMQKKFVT VGVDGSVYRF HPKFDKILDA KINDLLPKNL
460 470 480
DYQLMLSEDG SGRGAALVAA VADRIRKEHE
Length:480
Mass (Da):53,923
Last modified:July 9, 2014 - v2
Checksum:i4B9629DF8A1F3721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF575326 Genomic DNA. Translation: CDP97222.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF575326 Genomic DNA. Translation: CDP97222.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiA8PW64.
OMAiTEWGSFA.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Ghedin E.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA8PW64_BRUMA
AccessioniPrimary (citable) accession number: A8PW64
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: July 9, 2014
Last modified: July 22, 2015
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.