Reviewed, UniProtKB/Swiss-Prot A8PR17 (KAD1_MALGO)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	MGL_0573

Organism

Malassezia globosa (strain ATCC 96807 / CBS 7966) (Dandruff-associated fungus)

Taxonomic identifier

425265 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycotina incertae sedis › Malasseziales › Malassezia

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Adenylate kinase 1		PRO_0000365679
Regions
	Nucleotide binding	42 – 50	9	ATP By similarity
	Nucleotide binding	67 – 96	30	AMP By similarity
Sites
	Binding site	68	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8PR17-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 5BE65EDBBCDAC511	FASTA	256	28,329
	10 20 30 40 50 60 MSNPANTELS YLKSLVNELN EKIAVLEGKA PANQGVRMVL VGPPGAGKGT QAPKILERFQ 70 80 90 100 110 120 NMVCHLATGD LLRQQVAMGT DLGKQAKKIM DQGALVSDEI MVGMIKDQLE TNRSCKKGFI 130 140 150 160 170 180 LDGFPRTTPQ AEKLDQMLSD RKQKLDHVIE LQIPDELLIS RITGRLIHPG SGRSYHKIFS 190 200 210 220 230 240 PPKQPMKDDI TGEPLVQRSD DNEEALRKRL ATYHKQTTAV TDYYKKHGIW SPIDATQSPN 250 TVWQSISAIF NNGASA

References

[1]

"Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens." Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E., Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M., Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T., Chu L. , Sears R., Yuan B., Dawson T.L. Jr. Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007) [PubMed: 18000048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAYY01000001 Genomic DNA. Translation: EDP45584.1.
RefSeq	XP_001732798.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5857104.
KEGG	mgl:MGL_0573.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_MALGO

Accession

Primary (citable) accession number: A8PR17

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	January 15, 2008
Last modified:	October 13, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)