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Protein

DNA ligase

Gene

Bm-lig-1

Organism
Brugia malayi (Filarial nematode worm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Bm-lig-1Imported
ORF Names:BM_Bm2459dImported
OrganismiBrugia malayi (Filarial nematode worm)Imported
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
ProteomesiUP000026912 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiA8PIP2.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8PIP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSQLVGTTR NVENDWKTGE KIPYLCLAKT FEGIEATSSR LEIVKILASF
60 70 80 90 100
FMKVIERTPS ELATCVYLCV NKLGPTYEGM ELGIAEGALM KAIAQATGRK
110 120 130 140 150
IDKLKEDLNQ KGDLGLVAQM SRSNQRILFT PAPLTVTAVF HKLQDMAKTS
160 170 180 190 200
GHMAMNKKVD MIKSLLVSCR DCEARYLIRC LSGKLRIGLA EQSILAALAN
210 220 230 240 250
AFTDFEIKKT GEKLSCEKMK ERQAEDILLL RSTYSECPDY EKVVAAVLNG
260 270 280 290 300
GLSKLPEKCK ITPGIPVKPM LAHPTKGIAE VLKRFGGSVF ACEFKYDGER
310 320 330 340 350
AQIHYDSSGI KIFSRNQENN TDKYPDLKEL LKQIMDEETT SFIIDSEIVA
360 370 380 390 400
FDPIHETILP FQILSTRKRK NVGDSEIKVK VHVFMFDLLF WNGQSLTKSP
410 420 430 440 450
YRKRREMLQR HFKEVGGVCG FVASKDTEDT EQISEFLDDA IKGNCEGLMI
460 470 480 490 500
KTLDVDATYE IAKRSHSWLK LKKDYLDTIG DTVDLTVIGA FFGTGKRTGV
510 520 530 540 550
YGGYLLACYN PINEEYESIC KIGTGLTDDD LRQQHQYFEE LRIEKARPYY
560 570 580 590 600
SYDSSLKPDV WFDPKIVWEV KAADLSISPK HFAARGIVDL EKGISLRFPR
610 620 630 640
YIRRRTDKTP EEATTSQQIA DMYNNQEQIK NKVASSANDD NTDDYY
Length:646
Mass (Da):73,059
Last modified:July 9, 2014 - v2
Checksum:iB2087F7034D310A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF575152 Genomic DNA. Translation: CDQ03508.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF575152 Genomic DNA. Translation: CDQ03508.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiA8PIP2.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Ghedin E.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA8PIP2_BRUMA
AccessioniPrimary (citable) accession number: A8PIP2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: July 9, 2014
Last modified: May 27, 2015
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.