A8PAA1 (KAD1_COPC7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 1
Short name=AK 1
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 1
Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	CC1G_06132

Organism

Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)

Taxonomic identifier

240176 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Psathyrellaceae › Coprinopsis

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Adenylate kinase 1		PRO_0000365671
Regions
	Nucleotide binding	46 – 54	9	ATP By similarity
	Nucleotide binding	69 – 98	30	AMP By similarity
Sites
	Binding site	70	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8PAA1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 6DC7E33E54CA1A1C	FASTA	256	28,014
	10 20 30 40 50 60 MGASEELEYL KSLVAQLNDK IASLEAKAKG PASKTPAQQL RTILIGPPGA GKGTQAPRIR 70 80 90 100 110 120 DEFCVCHLAT GDMLRDQVEK KTPLGIAAKK IMDAGGLVSD DIMVNMIKDQ LENNEACKNG 130 140 150 160 170 180 FVLDGFPRTV PQAQKLDGML AERKEKLDSV VQLLIDDQLL ISRITGRLIH PASGRSYHKI 190 200 210 220 230 240 FNPPKKAGID DLTGEPLIQR SDDNAETLTR RLKTYHTQTG PVVDYYKAKG LWHGVDAAQS 250 PSVVWDSMRG IFAGRK

References

[1]

"Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)." Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M., Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J. , Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C., Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J., Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M., Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q., Zolan M.E., Pukkila P.J. Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010) [PubMed: 20547848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACS02000002 Genomic DNA. Translation: EAU81921.1.
RefSeq	XP_001839942.1. XM_001839890.2.
3D structure databases
ProteinModelPortal	A8PAA1.
SMR	A8PAA1. Positions 38-245.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6016565.
KEGG	cci:CC1G_06132.
Phylogenomic databases
OrthoDB	EOG4X0R28.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_COPC7

Accession

Primary (citable) accession number: A8PAA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	January 15, 2008
Last modified:	November 16, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program