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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei445PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERicopc7-kex1. Carboxypeptidase_S10.
MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CC1G_01392
OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri240176 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
Proteomesi
  • UP000001861 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CC1G_01392.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 520LumenalSequence analysisAdd BLAST497
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 618CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000041191724 – 618Pheromone-processing carboxypeptidase KEX1Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi442N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi240176.XP_001837480.1.

Structurei

3D structure databases

ProteinModelPortaliA8NYP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiA8NYP0.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8NYP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAIWTGFV TLFLCSFVQG APADNVLPSA ASFYVPSIPG IIPNPDYRLQ
60 70 80 90 100
IYAGHLPAES NKTLLASNDV TAHLYFVMVK NRRVADKERV VFWFNGGPGC
110 120 130 140 150
SSFDGLMMEV GPWRWDGQPE GKESFIVKEG GWEEYTTMVF VDQPPGTGFS
160 170 180 190 200
FTSTDQYAKT MKDAQWHILE FLRNFYQVFP EVLTMDTYLA GESFAGQWIP
210 220 230 240 250
YFADAILESS LQIPLRGIAI GNGWMDARRQ YLSYLDYSLK MGLIKDNSED
260 270 280 290 300
WKEVKAAHDR CEAHLEKLEG DPIHIRECGS IIMKVINQKR PDNEKGEKMC
310 320 330 340 350
LNMYDVRFTD TSPACGLNWP PEMHAITHFL GRKDVVRALH AERHPGSWVE
360 370 380 390 400
CRRPVHRAFK DGEEESSITV LPRVLSKIPV LIFAGDQDLI CNYVGLENMI
410 420 430 440 450
KSLTWNGETG LGTVETQSWS VNSTATGTWV ESRNLTYVKI FNASHMAPFD
460 470 480 490 500
LPHVTHDMML RFMGVNFSSI VGGSAMIPSS LGDAAKPVFV GGHLPQPSTP
510 520 530 540 550
ALPAGKTPEQ DKAMWEAYYN AGSAALVLVL IMLVIGLFIW YRRRKSRLQL
560 570 580 590 600
PSNQSGELAE ESIPLRSEME DRGGNGVSNG GAWKGKARAS EPVFEVGDSD
610
EDEPSPYRKP DGGGDRNV
Length:618
Mass (Da):68,888
Last modified:January 15, 2008 - v1
Checksum:iA6B18F31D04065E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000005 Genomic DNA. Translation: EAU84396.1.
RefSeqiXP_001837480.1. XM_001837428.2.

Genome annotation databases

EnsemblFungiiEAU84396; EAU84396; CC1G_01392.
GeneIDi6014036.
KEGGicci:CC1G_01392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000005 Genomic DNA. Translation: EAU84396.1.
RefSeqiXP_001837480.1. XM_001837428.2.

3D structure databases

ProteinModelPortaliA8NYP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240176.XP_001837480.1.

Protein family/group databases

ESTHERicopc7-kex1. Carboxypeptidase_S10.
MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAU84396; EAU84396; CC1G_01392.
GeneIDi6014036.
KEGGicci:CC1G_01392.

Organism-specific databases

EuPathDBiFungiDB:CC1G_01392.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiA8NYP0.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_COPC7
AccessioniPrimary (citable) accession number: A8NYP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.