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A8NR45

- ACEA_COPC7

UniProt

A8NR45 - ACEA_COPC7

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Protein

Isocitrate lyase

Gene

ACU-7

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei203 – 2031PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ACU-7
ORF Names:CC1G_07122
OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri240176 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
ProteomesiUP000001861: Unassembled WGS sequence

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Isocitrate lyasePRO_0000333260Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA8NR45.
SMRiA8NR45. Positions 1-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi536 – 5383Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

InParanoidiA8NR45.
KOiK01637.
OrthoDBiEOG73Z331.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8NR45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSERAQFAA EVAEVERWWK SPRFARVNRP YTAADVVSKR GTIKINYPSD
60 70 80 90 100
VQGKKLWKLL SEHAKNGTPS HTYGALDPVQ VTQMAKYLET VYVSGWQSSS
110 120 130 140 150
TASSSNEPGP DLADYPSNTV PNKVEHLFMA QLFHDRKQRE ARSRMSDAEL
160 170 180 190 200
ANTPVIDYLR PIVADADTGH GGLTAVMKLT KMFVEKGAAG IHIEDQAPGT
210 220 230 240 250
KKCGHMAGKV LVPIQEHINR LVAIRLQYDI MGVENLVVAR TDSEAATLIT
260 270 280 290 300
SNIDDRDHPF IQGSTNPSLP PLNNVMVEAE AQGKTGDQLQ AIEDGWIKAA
310 320 330 340 350
NLQLFPQALA QALANEGASR STVEKLVARV SRLSWPQAVA VAQKEFGLKQ
360 370 380 390 400
VPYWNWDAPR TREGYYRYQG GTECAIHRAN AFAPYADLLW METKKPILAQ
410 420 430 440 450
AKEFAAGVHA VHPGQWLAYN LSPSFNWEAA GLNAQDMQAY VWELGKLGFV
460 470 480 490 500
WQFITLAGLH SNAYISDLFA QNFAKTGMKA YVELVQSRER EIGCDVLTHQ
510 520 530
KWSGADYADS LIKTVTGGVS STAAMGAGVT ESQFTSKL
Length:538
Mass (Da):59,243
Last modified:January 15, 2008 - v1
Checksum:i75A0624B3453C0C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACS02000008 Genomic DNA. Translation: EAU86043.1.
RefSeqiXP_001835698.1. XM_001835646.1.

Genome annotation databases

GeneIDi6012236.
KEGGicci:CC1G_07122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACS02000008 Genomic DNA. Translation: EAU86043.1 .
RefSeqi XP_001835698.1. XM_001835646.1.

3D structure databases

ProteinModelPortali A8NR45.
SMRi A8NR45. Positions 1-518.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6012236.
KEGGi cci:CC1G_07122.

Phylogenomic databases

InParanoidi A8NR45.
KOi K01637.
OrthoDBi EOG73Z331.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)."
    Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M., Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.
    , Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C., Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J., Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M., Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q., Zolan M.E., Pukkila P.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003.

Entry informationi

Entry nameiACEA_COPC7
AccessioniPrimary (citable) accession number: A8NR45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3