A8NML1 (A8NML1_BRUMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Signal transduction protein CBL-B, putative EMBL EDP38565.1

Gene names

ORF Names:

Bm1_05660 EMBL EDP38565.1

Organism

Brugia malayi (Filarial nematode worm) [Complete proteome]

Taxonomic identifier

6279 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Brugia

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein ubiquitination Inferred from electronic annotation. Source: GOC regulation of signaling Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8NML1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 50124E63EF1666FD	FASTA	564	63,609
	10 20 30 40 50 60 MAVSGFASSI LNKIHEIVSG GAVSILHSYN GRSDTVAGPS NMMQIQDRRL VEKTFKLMDT 70 80 90 100 110 120 VVKHCQQPRL NLKNSPPFIL DILPDTYHQL STIISKNPNV LKDNTYLVLF LENVQSKCKQ 130 140 150 160 170 180 TMKLFKEDRE RIYDERSAAR RNLTKLSLIF SHMLAELKAE FPDGHFIGEN FRITKKEADA 190 200 210 220 230 240 FWRESFGIKT TVPWFEFRIA LSKVHRLNTG LETLALKTTI DLTVNEHISN FEFDVFTRLF 250 260 270 280 290 300 QPWNTLLHNW QLLAVTHPGY VAFLTYDEVK QKLQKYSNKP GSYVFRLSCT RLGQWAVGYV 310 320 330 340 350 360 APDGKIYQTI PQNKSLIQAL VDGSREGFYR FPDGRPTNPD LSHALQPSPE GRVKVTPEQY 370 380 390 400 410 420 QIYCEMGTTF EMCKICAENN KNVKLEPCGH LLCTPCLQSW QESDGGGTCP FCRCEIKGTE 430 440 450 460 470 480 RIIIDSFDPI EANKKLGYET IIEKSTVKNV RQSWPPRSEA VPPRRAPPLP PRYDSSSAGN 490 500 510 520 530 540 SPSVTHKQLI FDVPIASNNN MSTHNEGKLD QTRNDAIPNS TSQLKVLAPT TTEGSSYVNV 550 560 VTSGGKSNYE GLQYVNTAVI NGQT

References

[1]

"Draft genome of the filarial nematode parasite Brugia malayi." Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L. , Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.A., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L. Science 317:1756-1760(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS237641 Genomic DNA. Translation: EDP38565.1.
RefSeq	XP_001892605.1. XM_001892570.1.
3D structure databases
ProteinModelPortal	A8NML1.
SMR	A8NML1. Positions 47-427.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6096060.
KEGG	bmy:Bm1_05660.
Organism-specific databases
CTD	6096060.
Phylogenomic databases
InParanoid	A8NML1.
KO	K04707.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 1.20.930.20. 1 hit. 3.30.40.10. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR024162. Adaptor_Cbl. IPR014741. Adaptor_Cbl_EF_hand-like. IPR003153. Adaptor_Cbl_N_hlx. IPR014742. Adaptor_Cbl_SH2-like. IPR024159. Cbl_PTB. IPR011992. EF-hand-like_dom. IPR000980. SH2. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
PANTHER	PTHR23007. PTHR23007. 1 hit.
Pfam	PF02262. Cbl_N. 1 hit. PF02761. Cbl_N2. 1 hit. PF02762. Cbl_N3. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
SUPFAM	SSF47668. Adaptor_Cbl_N. 1 hit.
PROSITE	PS51506. CBL_PTB. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8NML1_BRUMA

Accession

Primary (citable) accession number: A8NML1

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	March 6, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)