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A8N8Z0 (NNRD_COPC7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydratase

EC=4.2.1.93
Alternative name(s):
ATP-dependent NAD(P)HX dehydratase
Gene names
ORF Names:CC1G_00865
OrganismCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) [Reference proteome]
Taxonomic identifier240176 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration By similarity. HAMAP-Rule MF_03157

Catalytic activity

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH. HAMAP-Rule MF_03157

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactor

Magnesium By similarity. HAMAP-Rule MF_03157

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03157.

Sequence similarities

Belongs to the NnrD/CARKD family.

Contains 1 YjeF C-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionLyase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent NAD(P)H-hydrate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336ATP-dependent (S)-NAD(P)H-hydrate dehydratase HAMAP-Rule MF_03157
PRO_0000416182

Regions

Domain7 – 328322YjeF C-terminal
Nucleotide binding202 – 2065ATP By similarity
Nucleotide binding244 – 25310ATP By similarity
Region164 – 1707NAD(P)HX By similarity

Sites

Binding site1111NAD(P)HX; via amide nitrogen By similarity
Binding site2541NAD(P)HX By similarity

Sequences

Sequence LengthMass (Da)Tools
A8N8Z0 [UniParc].

Last modified August 10, 2010. Version 2.
Checksum: 44F2F2B46A6B8EDC

FASTA33635,595
        10         20         30         40         50         60 
MPIPRTIIEQ IKRIIPPLDG SLHKGQSGRV GVLGGALDYT GAPFFAAFSA LRFGVDLSHV 

        70         80         90        100        110        120 
ICAPTAAGAI KSYSPDLIVH PILNESSSVD KVKSELQSLL SRLHVLVVGP GLGREPYMQS 

       130        140        150        160        170        180 
YARLAISLVR ERGMYLVLDA DALFLVGHDL SIIKGYRRAV LTPNVVEFKR LSEQVGVDPD 

       190        200        210        220        230        240 
APPDERAGVV SRMLGGVTVL QKGAKDIISV DTTGEEADLS ASHIEGADAE KEKIKETIAV 

       250        260        270        280        290        300 
DVEGGLKRCG GQGDVLSGCV GTFMAWGKCY ESGVYGDGTV PTSRVPLLAA VAGSMVTRTT 

       310        320        330 
SRRAYAKSGR SLITQDLLSE AGPAFEECFG GDKGRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACS02000007 Genomic DNA. Translation: EAU90481.2.
RefSeqXP_001831318.2. XM_001831266.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6007789.
KEGGcci:CC1G_00865.

Phylogenomic databases

KOK17757.
OrthoDBEOG7W15FV.

Family and domain databases

HAMAPMF_01965. NADHX_dehydratase.
InterProIPR017953. Carbohydrate_kinase_pred_CS.
IPR026599. NnrD/CARKD.
IPR000631. YjeF_C_carb_kinase-rel.
[Graphical view]
PfamPF01256. Carb_kinase. 2 hits.
[Graphical view]
TIGRFAMsTIGR00196. yjeF_cterm. 1 hit.
PROSITEPS01050. YJEF_C_2. 1 hit.
PS51383. YJEF_C_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNNRD_COPC7
AccessionPrimary (citable) accession number: A8N8Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families