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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

CC1G_00865

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei254NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ATPUniRule annotation5
Nucleotide bindingi244 – 253ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:CC1G_00865
OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri240176 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
Proteomesi
  • UP000001861 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CC1G_00865

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161821 – 336ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST336

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi240176.XP_001831318.2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 328YjeF C-terminalUniRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 170NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3974 Eukaryota
COG0063 LUCA
InParanoidiA8N8Z0
KOiK17757
OrthoDBiEOG092C4N4W

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 2 hits
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

A8N8Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIPRTIIEQ IKRIIPPLDG SLHKGQSGRV GVLGGALDYT GAPFFAAFSA
60 70 80 90 100
LRFGVDLSHV ICAPTAAGAI KSYSPDLIVH PILNESSSVD KVKSELQSLL
110 120 130 140 150
SRLHVLVVGP GLGREPYMQS YARLAISLVR ERGMYLVLDA DALFLVGHDL
160 170 180 190 200
SIIKGYRRAV LTPNVVEFKR LSEQVGVDPD APPDERAGVV SRMLGGVTVL
210 220 230 240 250
QKGAKDIISV DTTGEEADLS ASHIEGADAE KEKIKETIAV DVEGGLKRCG
260 270 280 290 300
GQGDVLSGCV GTFMAWGKCY ESGVYGDGTV PTSRVPLLAA VAGSMVTRTT
310 320 330
SRRAYAKSGR SLITQDLLSE AGPAFEECFG GDKGRL
Length:336
Mass (Da):35,595
Last modified:August 10, 2010 - v2
Checksum:i44F2F2B46A6B8EDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000007 Genomic DNA Translation: EAU90481.2
RefSeqiXP_001831318.2, XM_001831266.2

Genome annotation databases

EnsemblFungiiEAU90481; EAU90481; CC1G_00865
GeneIDi6007789
KEGGicci:CC1G_00865

Similar proteinsi

Entry informationi

Entry nameiNNRD_COPC7
AccessioniPrimary (citable) accession number: A8N8Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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