Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi560Zinc; catalyticPROSITE-ProRule annotation1
Active sitei561PROSITE-ProRule annotation1
Metal bindingi564Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi567Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CC1G_01835
OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri240176 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
Proteomesi
  • UP000001861 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CC1G_01835

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000033858039 – 776Mitochondrial intermediate peptidaseAdd BLAST738

Interactioni

Protein-protein interaction databases

STRINGi240176.XP_001829155.2

Structurei

3D structure databases

ProteinModelPortaliA8N2T3
SMRiA8N2T3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi489 – 492Poly-Asp4

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
InParanoidiA8N2T3
KOiK01410
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 1 hit
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8N2T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSARTVLA RHSARQLYRF RGCLVHQQRH RHQVQRTLAT HVQRHLPASL
60 70 80 90 100
DDKALVALFD QPNGSKLRSP FNTTGLFGHP NLTHPRALVS LAESTLVRAQ
110 120 130 140 150
LLTQRILEAG KSEHELAKVV KNLDRLSDML CGVIDLAELV RNAHPDRLWV
160 170 180 190 200
EAANHAYETL CEFMNVLNTH TGLYEVLKQV LSNPTLVNSL SPEAYQTALI
210 220 230 240 250
FWRDFEKSAI DLPPAQRNKF VSLSSDILVL GRQFLENAST PRPPTSIKAS
260 270 280 290 300
DLAGLKDKGM GVRLQLQAQF TNRDLQIYPG SLQAHMIMRS APNEEPRRRL
310 320 330 340 350
YLAANSSTQE QIEVLEALLK KRAELAQLVG RESFAHMTLD DKMAKTPDNV
360 370 380 390 400
TNFLDALIDH TRPFARSALR TLAQRKQAHH GLSSLPIIQA WDRDFYCPPD
410 420 430 440 450
PPAPPIPLPP LTLGTVFMGL SRLFRHLYGV SLRPVPSASG EVWHTDVQKL
460 470 480 490 500
EVVDEDQGII GWIYADLFAR RGKASGAAHY TVRCSRRTDD DDEQGDGMFE
510 520 530 540 550
GAELQILESQ EFEAVKRHRL PNQEGVFQLP LVVLLCEFTR PTVSKGGTIL
560 570 580 590 600
EWHEVQTLFH EMGHAMHSML GRTEYQNVSG TRCATDFVEL PSILMEHFLN
610 620 630 640 650
SPAVLSLFDA DGTSTLRQIG NHHHDPCHAI DTYSQIMLAV VDQIYHSPTV
660 670 680 690 700
LDPSFDSTRE YGNLQNTRGL IPYVPGTSYQ TQFGHLFGYG ATYYSYLFDR
710 720 730 740 750
AIASRVWSKV FSKDPLDREL GEKYKREVLR WGGARDPWEM VATLLDAPEL
760 770
AAGDAEAMRE VGRWRIEDEV GVGGRH
Length:776
Mass (Da):87,377
Last modified:March 8, 2011 - v2
Checksum:i359633EECC153F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000001 Genomic DNA Translation: EAU92790.2
RefSeqiXP_001829155.2, XM_001829103.2

Genome annotation databases

EnsemblFungiiEAU92790; EAU92790; CC1G_01835
GeneIDi6005581
KEGGicci:CC1G_01835

Similar proteinsi

Entry informationi

Entry nameiPMIP_COPC7
AccessioniPrimary (citable) accession number: A8N2T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health