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A8N2T3

- PMIP_COPC7

UniProt

A8N2T3 - PMIP_COPC7

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
Active sitei561 – 5611PROSITE-ProRule annotation
Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CC1G_01835
OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri240176 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
ProteomesiUP000001861: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionSequence AnalysisAdd
BLAST
Chaini39 – 776738Mitochondrial intermediate peptidasePRO_0000338580Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8N2T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi489 – 4924Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiA8N2T3.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8N2T3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNSARTVLA RHSARQLYRF RGCLVHQQRH RHQVQRTLAT HVQRHLPASL
60 70 80 90 100
DDKALVALFD QPNGSKLRSP FNTTGLFGHP NLTHPRALVS LAESTLVRAQ
110 120 130 140 150
LLTQRILEAG KSEHELAKVV KNLDRLSDML CGVIDLAELV RNAHPDRLWV
160 170 180 190 200
EAANHAYETL CEFMNVLNTH TGLYEVLKQV LSNPTLVNSL SPEAYQTALI
210 220 230 240 250
FWRDFEKSAI DLPPAQRNKF VSLSSDILVL GRQFLENAST PRPPTSIKAS
260 270 280 290 300
DLAGLKDKGM GVRLQLQAQF TNRDLQIYPG SLQAHMIMRS APNEEPRRRL
310 320 330 340 350
YLAANSSTQE QIEVLEALLK KRAELAQLVG RESFAHMTLD DKMAKTPDNV
360 370 380 390 400
TNFLDALIDH TRPFARSALR TLAQRKQAHH GLSSLPIIQA WDRDFYCPPD
410 420 430 440 450
PPAPPIPLPP LTLGTVFMGL SRLFRHLYGV SLRPVPSASG EVWHTDVQKL
460 470 480 490 500
EVVDEDQGII GWIYADLFAR RGKASGAAHY TVRCSRRTDD DDEQGDGMFE
510 520 530 540 550
GAELQILESQ EFEAVKRHRL PNQEGVFQLP LVVLLCEFTR PTVSKGGTIL
560 570 580 590 600
EWHEVQTLFH EMGHAMHSML GRTEYQNVSG TRCATDFVEL PSILMEHFLN
610 620 630 640 650
SPAVLSLFDA DGTSTLRQIG NHHHDPCHAI DTYSQIMLAV VDQIYHSPTV
660 670 680 690 700
LDPSFDSTRE YGNLQNTRGL IPYVPGTSYQ TQFGHLFGYG ATYYSYLFDR
710 720 730 740 750
AIASRVWSKV FSKDPLDREL GEKYKREVLR WGGARDPWEM VATLLDAPEL
760 770
AAGDAEAMRE VGRWRIEDEV GVGGRH
Length:776
Mass (Da):87,377
Last modified:March 8, 2011 - v2
Checksum:i359633EECC153F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000001 Genomic DNA. Translation: EAU92790.2.
RefSeqiXP_001829155.2. XM_001829103.2.

Genome annotation databases

GeneIDi6005581.
KEGGicci:CC1G_01835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACS02000001 Genomic DNA. Translation: EAU92790.2 .
RefSeqi XP_001829155.2. XM_001829103.2.

3D structure databases

ProteinModelPortali A8N2T3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6005581.
KEGGi cci:CC1G_01835.

Phylogenomic databases

InParanoidi A8N2T3.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)."
    Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M., Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.
    , Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C., Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J., Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M., Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q., Zolan M.E., Pukkila P.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003.

Entry informationi

Entry nameiPMIP_COPC7
AccessioniPrimary (citable) accession number: A8N2T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 8, 2011
Last modified: November 26, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3