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A8N2T3

- PMIP_COPC7

UniProt

A8N2T3 - PMIP_COPC7

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 2 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
    Active sitei561 – 5611PROSITE-ProRule annotation
    Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi567 – 5671Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:CC1G_01835
    OrganismiCoprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
    Taxonomic identifieri240176 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis
    ProteomesiUP000001861: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3838MitochondrionSequence AnalysisAdd
    BLAST
    Chaini39 – 776738Mitochondrial intermediate peptidasePRO_0000338580Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA8N2T3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi489 – 4924Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8N2T3-1 [UniParc]FASTAAdd to Basket

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    MLNSARTVLA RHSARQLYRF RGCLVHQQRH RHQVQRTLAT HVQRHLPASL    50
    DDKALVALFD QPNGSKLRSP FNTTGLFGHP NLTHPRALVS LAESTLVRAQ 100
    LLTQRILEAG KSEHELAKVV KNLDRLSDML CGVIDLAELV RNAHPDRLWV 150
    EAANHAYETL CEFMNVLNTH TGLYEVLKQV LSNPTLVNSL SPEAYQTALI 200
    FWRDFEKSAI DLPPAQRNKF VSLSSDILVL GRQFLENAST PRPPTSIKAS 250
    DLAGLKDKGM GVRLQLQAQF TNRDLQIYPG SLQAHMIMRS APNEEPRRRL 300
    YLAANSSTQE QIEVLEALLK KRAELAQLVG RESFAHMTLD DKMAKTPDNV 350
    TNFLDALIDH TRPFARSALR TLAQRKQAHH GLSSLPIIQA WDRDFYCPPD 400
    PPAPPIPLPP LTLGTVFMGL SRLFRHLYGV SLRPVPSASG EVWHTDVQKL 450
    EVVDEDQGII GWIYADLFAR RGKASGAAHY TVRCSRRTDD DDEQGDGMFE 500
    GAELQILESQ EFEAVKRHRL PNQEGVFQLP LVVLLCEFTR PTVSKGGTIL 550
    EWHEVQTLFH EMGHAMHSML GRTEYQNVSG TRCATDFVEL PSILMEHFLN 600
    SPAVLSLFDA DGTSTLRQIG NHHHDPCHAI DTYSQIMLAV VDQIYHSPTV 650
    LDPSFDSTRE YGNLQNTRGL IPYVPGTSYQ TQFGHLFGYG ATYYSYLFDR 700
    AIASRVWSKV FSKDPLDREL GEKYKREVLR WGGARDPWEM VATLLDAPEL 750
    AAGDAEAMRE VGRWRIEDEV GVGGRH 776
    Length:776
    Mass (Da):87,377
    Last modified:March 8, 2011 - v2
    Checksum:i359633EECC153F99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACS02000001 Genomic DNA. Translation: EAU92790.2.
    RefSeqiXP_001829155.2. XM_001829103.2.

    Genome annotation databases

    GeneIDi6005581.
    KEGGicci:CC1G_01835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACS02000001 Genomic DNA. Translation: EAU92790.2 .
    RefSeqi XP_001829155.2. XM_001829103.2.

    3D structure databases

    ProteinModelPortali A8N2T3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6005581.
    KEGGi cci:CC1G_01835.

    Phylogenomic databases

    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)."
      Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M., Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.
      , Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C., Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J., Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M., Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q., Zolan M.E., Pukkila P.J.
      Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003.

    Entry informationi

    Entry nameiPMIP_COPC7
    AccessioniPrimary (citable) accession number: A8N2T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3