A8MZ97 (CB074_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C2orf74

Gene names

Name:

C2orf74

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Uncharacterized protein C2orf74		PRO_0000343566
Regions
	Transmembrane	15 – 35	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A8MZ97 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: DD90134F5F912145	FASTA	194	21,915
	10 20 30 40 50 60 MSLLAKPMSF ETTAITFFII LLICLICILL LLVVFLYKCF QGRKGKETKK VPCTDANGGV 70 80 90 100 110 120 DCAAAKVVTS NPEDHERILM QVMNLNVPMR PGILVQRQSK EVLATPLENR RDMEAEEENQ 130 140 150 160 170 180 INEKQEPENA GETGQEEDDG LQKIHTSVTR TPSVVESQKR PLKGVTFSRE VIVVDLGNEY 190 PTPRSYTREH KERK

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC016747 Genomic DNA. No translation available.
IPI	IPI00872282.
RefSeq	NP_001137431.1. NM_001143959.1.
UniGene	Hs.140617.
3D structure databases
ProteinModelPortal	A8MZ97.
ModBase	Search...
Protein-protein interaction databases
IntAct	A8MZ97. 1 interaction.
PTM databases
PhosphoSite	A8MZ97.
Proteomic databases
PaxDb	A8MZ97.
PRIDE	A8MZ97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000432605; ENSP00000402915; ENSG00000237651.
GeneID	339804.
KEGG	hsa:339804.
UCSC	uc010ypl.1. human.
Organism-specific databases
CTD	339804.
GeneCards	GC02P061372.
HGNC	HGNC:34439. C2orf74.
HPA	HPA026826.
neXtProt	NX_A8MZ97.
PharmGKB	PA162379547.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43234.
HOGENOM	HOG000111333.
HOVERGEN	HBG107583.
InParanoid	A8MZ97.
OMA	HISVTRT.
OrthoDB	EOG4FFD2X.
Gene expression databases
ArrayExpress	A8MZ97.
Bgee	A8MZ97.
CleanEx	HS_C2orf74.
Genevestigator	A8MZ97.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	339804.
NextBio	97553.

Entry information

Entry name

CB074_HUMAN

Accession

Primary (citable) accession number: A8MZ97
Secondary accession number(s): C9JP62

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	November 24, 2009
Last modified:	April 3, 2013
This is version 42 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.