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A8MZ97 (CB074_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C2orf74
Gene names
Name:C2orf74
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Uncharacterized protein C2orf74
PRO_0000343566

Regions

Transmembrane15 – 3521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A8MZ97 [UniParc].

Last modified November 24, 2009. Version 3.
Checksum: DD90134F5F912145

FASTA19421,915
        10         20         30         40         50         60 
MSLLAKPMSF ETTAITFFII LLICLICILL LLVVFLYKCF QGRKGKETKK VPCTDANGGV 

        70         80         90        100        110        120 
DCAAAKVVTS NPEDHERILM QVMNLNVPMR PGILVQRQSK EVLATPLENR RDMEAEEENQ 

       130        140        150        160        170        180 
INEKQEPENA GETGQEEDDG LQKIHTSVTR TPSVVESQKR PLKGVTFSRE VIVVDLGNEY 

       190 
PTPRSYTREH KERK 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC016747 Genomic DNA. No translation available.
RefSeqNP_001137431.1. NM_001143959.1.
XP_005264344.1. XM_005264287.2.
UniGeneHs.140617.

3D structure databases

ProteinModelPortalA8MZ97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130940. 2 interactions.
IntActA8MZ97. 1 interaction.

PTM databases

PhosphoSiteA8MZ97.

Proteomic databases

PaxDbA8MZ97.
PRIDEA8MZ97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000432605; ENSP00000402915; ENSG00000237651.
GeneID339804.
KEGGhsa:339804.
UCSCuc010ypl.1. human.

Organism-specific databases

CTD339804.
GeneCardsGC02P061372.
HGNCHGNC:34439. C2orf74.
HPAHPA026826.
neXtProtNX_A8MZ97.
PharmGKBPA162379547.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43234.
HOGENOMHOG000111333.
HOVERGENHBG107583.
InParanoidA8MZ97.
OMADHERRVI.
OrthoDBEOG70W3GF.
PhylomeDBA8MZ97.

Gene expression databases

BgeeA8MZ97.
CleanExHS_C2orf74.
GenevestigatorA8MZ97.

Family and domain databases

InterProIPR027813. DUF4642.
[Graphical view]
PfamPF15484. DUF4642. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339804.
NextBio97553.

Entry information

Entry nameCB074_HUMAN
AccessionPrimary (citable) accession number: A8MZ97
Secondary accession number(s): C9JP62
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM