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Protein

Uncharacterized protein C2orf74

Gene

C2orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf74
Gene namesi
Name:C2orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:34439. C2orf74.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Uncharacterized protein C2orf74PRO_0000343566Add
BLAST

Proteomic databases

MaxQBiA8MZ97.
PaxDbiA8MZ97.
PRIDEiA8MZ97.

PTM databases

PhosphoSiteiA8MZ97.

Expressioni

Gene expression databases

BgeeiA8MZ97.
CleanExiHS_C2orf74.
ExpressionAtlasiA8MZ97. baseline.
GenevestigatoriA8MZ97.

Organism-specific databases

HPAiHPA026826.

Interactioni

Protein-protein interaction databases

BioGridi130940. 1 interaction.
IntActiA8MZ97. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8MZ97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43234.
GeneTreeiENSGT00390000004911.
HOGENOMiHOG000111333.
HOVERGENiHBG107583.
InParanoidiA8MZ97.
OMAiPAANTEM.
OrthoDBiEOG70W3GF.
PhylomeDBiA8MZ97.

Family and domain databases

InterProiIPR027813. DUF4642.
[Graphical view]
PfamiPF15484. DUF4642. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MZ97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLAKPMSF ETTAITFFII LLICLICILL LLVVFLYKCF QGRKGKETKK
60 70 80 90 100
VPCTDANGGV DCAAAKVVTS NPEDHERILM QVMNLNVPMR PGILVQRQSK
110 120 130 140 150
EVLATPLENR RDMEAEEENQ INEKQEPENA GETGQEEDDG LQKIHTSVTR
160 170 180 190
TPSVVESQKR PLKGVTFSRE VIVVDLGNEY PTPRSYTREH KERK
Length:194
Mass (Da):21,915
Last modified:November 24, 2009 - v3
Checksum:iDD90134F5F912145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016747 Genomic DNA. No translation available.
RefSeqiNP_001137431.1. NM_001143959.1.
XP_005264344.1. XM_005264287.2.
UniGeneiHs.140617.

Genome annotation databases

EnsembliENST00000432605; ENSP00000402915; ENSG00000237651.
GeneIDi339804.
KEGGihsa:339804.
UCSCiuc010ypl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016747 Genomic DNA. No translation available.
RefSeqiNP_001137431.1. NM_001143959.1.
XP_005264344.1. XM_005264287.2.
UniGeneiHs.140617.

3D structure databases

ProteinModelPortaliA8MZ97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130940. 1 interaction.
IntActiA8MZ97. 1 interaction.

PTM databases

PhosphoSiteiA8MZ97.

Proteomic databases

MaxQBiA8MZ97.
PaxDbiA8MZ97.
PRIDEiA8MZ97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432605; ENSP00000402915; ENSG00000237651.
GeneIDi339804.
KEGGihsa:339804.
UCSCiuc010ypl.1. human.

Organism-specific databases

CTDi339804.
GeneCardsiGC02P061372.
HGNCiHGNC:34439. C2orf74.
HPAiHPA026826.
neXtProtiNX_A8MZ97.
PharmGKBiPA162379547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43234.
GeneTreeiENSGT00390000004911.
HOGENOMiHOG000111333.
HOVERGENiHBG107583.
InParanoidiA8MZ97.
OMAiPAANTEM.
OrthoDBiEOG70W3GF.
PhylomeDBiA8MZ97.

Miscellaneous databases

ChiTaRSiC2orf74. human.
GenomeRNAii339804.
NextBioi97553.

Gene expression databases

BgeeiA8MZ97.
CleanExiHS_C2orf74.
ExpressionAtlasiA8MZ97. baseline.
GenevestigatoriA8MZ97.

Family and domain databases

InterProiIPR027813. DUF4642.
[Graphical view]
PfamiPF15484. DUF4642. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCB074_HUMAN
AccessioniPrimary (citable) accession number: A8MZ97
Secondary accession number(s): C9JP62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 51 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.