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Protein

Forkhead box protein O6

Gene

FOXO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi88 – 182Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiA8MYZ6.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein O6
Gene namesi
Name:FOXO6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000204060.5.
HGNCiHGNC:24814. FOXO6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100132074.
OpenTargetsiENSG00000204060.
PharmGKBiPA162388893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174131 – 492Forkhead box protein O6Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA8MYZ6.
MaxQBiA8MYZ6.
PaxDbiA8MYZ6.
PRIDEiA8MYZ6.

PTM databases

iPTMnetiA8MYZ6.
PhosphoSitePlusiA8MYZ6.

Expressioni

Gene expression databases

BgeeiENSG00000204060.
GenevisibleiA8MYZ6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNF4AP412352EBI-8531039,EBI-1049011

Protein-protein interaction databases

IntActiA8MYZ6. 10 interactors.
STRINGi9606.ENSP00000361672.

Structurei

3D structure databases

ProteinModelPortaliA8MYZ6.
SMRiA8MYZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 408Gly-richAdd BLAST104
Compositional biasi349 – 429Ala-richAdd BLAST81
Compositional biasi473 – 485Pro-richAdd BLAST13

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
HOGENOMiHOG000251635.
HOVERGENiHBG057789.
InParanoidiA8MYZ6.
PhylomeDBiA8MYZ6.

Family and domain databases

CDDicd00059. FH. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR030456. TF_fork_head_CS_2.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MYZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGA
60 70 80 90 100
EDCGPERRAT APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA
110 120 130 140 150
IESAPDKRLT LSQIYDWMVR YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR
160 170 180 190 200
FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR RAVSMDNGAK FLRIKGKASK
210 220 230 240 250
KKQLQAPERS PDDSSPSAPA PGPVPAAAKW AASPASHASD DYEAWADFRG
260 270 280 290 300
GGRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GSRCPGELPR
310 320 330 340 350
LAELGGPLGL HGGGGAGLPE GLLDGAQDAY GPRPAPRPGP VLGAPGELAL
360 370 380 390 400
AGAAAAYPGK GAAPYAPPAP SRSALAHPIS LMTLPGEAGA AGLAPPGHAA
410 420 430 440 450
AFGGPPGGLL LDALPGPYAA AAAGPLGAAP DRFPADLDLD MFSGSLECDV
460 470 480 490
ESIILNDFMD SDEMDFNFDS ALPPPPPGLA GAPPPNQSWV PG
Length:492
Mass (Da):50,595
Last modified:December 4, 2007 - v1
Checksum:i85061867EDA1D656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093151 Genomic DNA. No translation available.
UniGeneiHs.559677.

Genome annotation databases

EnsembliENST00000641094; ENSP00000493184; ENSG00000204060.
UCSCiuc057fie.1. human.

Similar proteinsi

Entry informationi

Entry nameiFOXO6_HUMAN
AccessioniPrimary (citable) accession number: A8MYZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot