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A8MYZ6 (FOXO6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein O6
Gene names
Name:FOXO6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors By similarity.

Post-translational modification

Phosphorylation of Ser-184 is be important in regulating the transacriptional activity By similarity.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HNF4AP412352EBI-8531039,EBI-1049011

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Forkhead box protein O6
PRO_0000317413

Regions

DNA binding88 – 18295Fork-head
Compositional bias305 – 408104Gly-rich
Compositional bias349 – 42981Ala-rich
Compositional bias473 – 48513Pro-rich

Amino acid modifications

Modified residue1841Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MYZ6 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 85061867EDA1D656

FASTA49250,595
        10         20         30         40         50         60 
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGA EDCGPERRAT 

        70         80         90        100        110        120 
APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR 

       130        140        150        160        170        180 
YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR 

       190        200        210        220        230        240 
RAVSMDNGAK FLRIKGKASK KKQLQAPERS PDDSSPSAPA PGPVPAAAKW AASPASHASD 

       250        260        270        280        290        300 
DYEAWADFRG GGRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GSRCPGELPR 

       310        320        330        340        350        360 
LAELGGPLGL HGGGGAGLPE GLLDGAQDAY GPRPAPRPGP VLGAPGELAL AGAAAAYPGK 

       370        380        390        400        410        420 
GAAPYAPPAP SRSALAHPIS LMTLPGEAGA AGLAPPGHAA AFGGPPGGLL LDALPGPYAA 

       430        440        450        460        470        480 
AAAGPLGAAP DRFPADLDLD MFSGSLECDV ESIILNDFMD SDEMDFNFDS ALPPPPPGLA 

       490 
GAPPPNQSWV PG 

« Hide

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC093151 Genomic DNA. No translation available.
UniGeneHs.559677.

3D structure databases

ProteinModelPortalA8MYZ6.
SMRA8MYZ6. Positions 82-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActA8MYZ6. 1 interaction.
STRING9606.ENSP00000361672.

PTM databases

PhosphoSiteA8MYZ6.

Proteomic databases

PaxDbA8MYZ6.
PRIDEA8MYZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC01P041827.
HGNCHGNC:24814. FOXO6.
MIM611457. gene.
neXtProtNX_A8MYZ6.
PharmGKBPA162388893.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000251635.
HOVERGENHBG057789.
PhylomeDBA8MYZ6.

Gene expression databases

GenevestigatorA8MYZ6.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio21552382.
PROA8MYZ6.
SOURCESearch...

Entry information

Entry nameFOXO6_HUMAN
AccessionPrimary (citable) accession number: A8MYZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 4, 2007
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM