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Protein

Doublecortin domain-containing protein 2C

Gene

DCDC2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2C
Gene namesi
Name:DCDC2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32696. DCDC2C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Doublecortin domain-containing protein 2CPRO_0000344449Add
BLAST

Proteomic databases

PaxDbiA8MYV0.
PRIDEiA8MYV0.

PTM databases

PhosphoSiteiA8MYV0.

Expressioni

Gene expression databases

BgeeiA8MYV0.
ExpressionAtlasiA8MYV0. baseline.

Organism-specific databases

HPAiHPA045848.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000403984.

Structurei

3D structure databases

ProteinModelPortaliA8MYV0.
SMRiA8MYV0. Positions 15-97, 138-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9883Doublecortin 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 21782Doublecortin 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG116978.
InParanoidiA8MYV0.
PhylomeDBiA8MYV0.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
[Graphical view]
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MYV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRGPSAPV DTTPAKTIVV YRNGDPFYVG KKFVLSRRRA ATFEALLEQL
60 70 80 90 100
TEQVDVPFGV RRLFTPTRGH RVLGLDALQA GGKYVAAGRE RFKELDYIHI
110 120 130 140 150
VPRKPAKIRK LKEIKPVVHC DINVPSKWQT YHRISRHINV FTNGRLFIPP
160 170 180 190 200
AKIIIPKFSL SDWDIVLATI GEKVFPLGGV RKLFTMNGHL LGDSKDLQDN
210 220 230 240 250
HFYVAVGLET FKYFPYWKSP RVPSEVQQRY ANVEKNSQRK KKVDSKGKEP
260 270 280 290 300
CKYDGIPPKT QDSVYYAKEE KKKTLAEPLV QRGAEGDVYK APTPSKETQG
310 320 330 340 350
ALDVKEEHNV QLEVPVDQAE SSCDKHCCHN FAYNKHIHKF WLPVILISID

FEAVE
Length:355
Mass (Da):40,425
Last modified:February 8, 2011 - v3
Checksum:iAC2BD3EDED18C794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010907 Genomic DNA. No translation available.
AC019172 Genomic DNA. No translation available.
UniGeneiHs.304233.
Hs.631689.

Genome annotation databases

EnsembliENST00000399143; ENSP00000382097; ENSG00000214866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010907 Genomic DNA. No translation available.
AC019172 Genomic DNA. No translation available.
UniGeneiHs.304233.
Hs.631689.

3D structure databases

ProteinModelPortaliA8MYV0.
SMRiA8MYV0. Positions 15-97, 138-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000403984.

PTM databases

PhosphoSiteiA8MYV0.

Proteomic databases

PaxDbiA8MYV0.
PRIDEiA8MYV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399143; ENSP00000382097; ENSG00000214866.

Organism-specific databases

GeneCardsiGC02P003750.
HGNCiHGNC:32696. DCDC2C.
HPAiHPA045848.
neXtProtiNX_A8MYV0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116978.
InParanoidiA8MYV0.
PhylomeDBiA8MYV0.

Miscellaneous databases

PROiA8MYV0.

Gene expression databases

BgeeiA8MYV0.
ExpressionAtlasiA8MYV0. baseline.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
[Graphical view]
PfamiPF03607. DCX. 2 hits.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
[Graphical view]
PROSITEiPS50309. DC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDCD2C_HUMAN
AccessioniPrimary (citable) accession number: A8MYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 8, 2011
Last modified: June 24, 2015
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.