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Protein

Phosphatidylinositol 3-kinase

Gene

PIK3C3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinaseUniRule annotation (EC:2.7.1.137UniRule annotation)
Gene namesi
Name:PIK3C3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:8974. PIK3C3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078142.

PTM / Processingi

Proteomic databases

MaxQBiA8MYT4.
PaxDbiA8MYT4.
PeptideAtlasiA8MYT4.
PRIDEiA8MYT4.

Expressioni

Gene expression databases

BgeeiENSG00000078142.
ExpressionAtlasiA8MYT4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262039.

Structurei

3D structure databases

ProteinModelPortaliA8MYT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 121C2 PI3K-typeInterPro annotationAdd BLAST121
Domaini220 – 457PIK helicalInterPro annotationAdd BLAST238
Domaini568 – 822PI3K/PI4KInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0906. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000174003.
HOVERGENiHBG082145.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 2 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MYT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAEKFHYI YSCDLDINVQ LKIWNEWLKL PVKYPDLPRN AQVALTIWDV
60 70 80 90 100
YGPGKAVPVG GTTVSLFGKY GMFRQGMHDL KVWPNVEADG SEPTKTPGRT
110 120 130 140 150
SSTLSEDQMS RLAKLTKAHR QGHMVKVDWL DRLTFREIEM INESEKRSSN
160 170 180 190 200
FMYLMVEFRC VKCDDKEYGI VYYEKDGDES SPILTSFELV KVPDPQMSME
210 220 230 240 250
NLVESKHHKL ARSLRSGPSD HDLKPNAATR DQLNIIVSYP PTKQLTYEEQ
260 270 280 290 300
DLVWKFRYYL TNQEKALTKF LKCVNWDLPQ EAKQALELLG KWKPMDVEDS
310 320 330 340 350
LELLSSHYTN PTVRRYAVAR LRQADDEDLL MYLLQLVQAL KYENFDDIKN
360 370 380 390 400
GLEPTKKDSQ SSVSENVSNS GINSAEIDSS QIITSPLPSV SSPPPASKTK
410 420 430 440 450
EVPDGENLEQ DLCTFLISRA CKNSTLANYL YWYVIVECED QDTQQRDPKT
460 470 480 490 500
HEMYLNVMRR FSQALLKGDK SVRVMRSLLA AQQTFVDRLV HLMKAVQRES
510 520 530 540 550
GNRKKKNERL QALLGDNEKM NLSDVELIPL PLEPQVKIRG IIPETATLFK
560 570 580 590 600
SALMPAQLFF KTEDGGKYPV IFKHGDDLRQ DQLILQIISL MDKLLRKENL
610 620 630 640 650
DLKLTPYKVL ATSTKHGFMQ FIQSVPVAEV LDTEGSIQNF FRKYAPSENG
660 670 680 690 700
PNGISAEVMD TYVKSCAGYC VITYILGVGD RHLDNLLLTK TGKLFHIDFG
710 720 730 740 750
YILGRDPKPL PPPMKLNKEM VEGMGGTQSE QYQEFRKQCY TAFLHLRRYS
760 770 780 790 800
NLILNLFSLM VDANIPDIAL EPDKTVKKVQ DKFRLDLSDE EAVHYMQSLI
810 820
DESVHALFAA VVEQIHKFAQ YWRK
Length:824
Mass (Da):94,400
Last modified:June 28, 2011 - v2
Checksum:i32C4721A6B2576F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087683 Genomic DNA. No translation available.
AMYH02034608 Genomic DNA. No translation available.
KF495756 Genomic DNA. No translation available.
RefSeqiNP_001294949.1. NM_001308020.1.
UniGeneiHs.464971.
Hs.656958.

Genome annotation databases

EnsembliENST00000398870; ENSP00000381845; ENSG00000078142.
GeneIDi5289.
UCSCiuc010xcl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087683 Genomic DNA. No translation available.
AMYH02034608 Genomic DNA. No translation available.
KF495756 Genomic DNA. No translation available.
RefSeqiNP_001294949.1. NM_001308020.1.
UniGeneiHs.464971.
Hs.656958.

3D structure databases

ProteinModelPortaliA8MYT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262039.

Proteomic databases

MaxQBiA8MYT4.
PaxDbiA8MYT4.
PeptideAtlasiA8MYT4.
PRIDEiA8MYT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398870; ENSP00000381845; ENSG00000078142.
GeneIDi5289.
UCSCiuc010xcl.3. human.

Organism-specific databases

CTDi5289.
HGNCiHGNC:8974. PIK3C3.
OpenTargetsiENSG00000078142.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0906. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000174003.
HOVERGENiHBG082145.

Miscellaneous databases

ChiTaRSiPIK3C3. human.
GenomeRNAii5289.

Gene expression databases

BgeeiENSG00000078142.
ExpressionAtlasiA8MYT4. baseline and differential.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 2 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8MYT4_HUMAN
AccessioniPrimary (citable) accession number: A8MYT4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.