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Protein
Submitted name:

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

PIK3C3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase catalytic subunit type 3Imported
Gene namesi
Name:PIK3C3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000078142.11
HGNCiHGNC:8974 PIK3C3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078142

PTM / Processingi

Proteomic databases

MaxQBiA8MYT4
PeptideAtlasiA8MYT4
PRIDEiA8MYT4

Expressioni

Gene expression databases

BgeeiENSG00000078142
ExpressionAtlasiA8MYT4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA8MYT4
SMRiA8MYT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 121C2 PI3K-typeInterPro annotationAdd BLAST121
Domaini220 – 457PIK helicalInterPro annotationAdd BLAST238
Domaini568 – 822PI3K/PI4KInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0906 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
HOGENOMiHOG000174003
HOVERGENiHBG082145

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 2 hits
SMARTiView protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

A8MYT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAEKFHYI YSCDLDINVQ LKIWNEWLKL PVKYPDLPRN AQVALTIWDV
60 70 80 90 100
YGPGKAVPVG GTTVSLFGKY GMFRQGMHDL KVWPNVEADG SEPTKTPGRT
110 120 130 140 150
SSTLSEDQMS RLAKLTKAHR QGHMVKVDWL DRLTFREIEM INESEKRSSN
160 170 180 190 200
FMYLMVEFRC VKCDDKEYGI VYYEKDGDES SPILTSFELV KVPDPQMSME
210 220 230 240 250
NLVESKHHKL ARSLRSGPSD HDLKPNAATR DQLNIIVSYP PTKQLTYEEQ
260 270 280 290 300
DLVWKFRYYL TNQEKALTKF LKCVNWDLPQ EAKQALELLG KWKPMDVEDS
310 320 330 340 350
LELLSSHYTN PTVRRYAVAR LRQADDEDLL MYLLQLVQAL KYENFDDIKN
360 370 380 390 400
GLEPTKKDSQ SSVSENVSNS GINSAEIDSS QIITSPLPSV SSPPPASKTK
410 420 430 440 450
EVPDGENLEQ DLCTFLISRA CKNSTLANYL YWYVIVECED QDTQQRDPKT
460 470 480 490 500
HEMYLNVMRR FSQALLKGDK SVRVMRSLLA AQQTFVDRLV HLMKAVQRES
510 520 530 540 550
GNRKKKNERL QALLGDNEKM NLSDVELIPL PLEPQVKIRG IIPETATLFK
560 570 580 590 600
SALMPAQLFF KTEDGGKYPV IFKHGDDLRQ DQLILQIISL MDKLLRKENL
610 620 630 640 650
DLKLTPYKVL ATSTKHGFMQ FIQSVPVAEV LDTEGSIQNF FRKYAPSENG
660 670 680 690 700
PNGISAEVMD TYVKSCAGYC VITYILGVGD RHLDNLLLTK TGKLFHIDFG
710 720 730 740 750
YILGRDPKPL PPPMKLNKEM VEGMGGTQSE QYQEFRKQCY TAFLHLRRYS
760 770 780 790 800
NLILNLFSLM VDANIPDIAL EPDKTVKKVQ DKFRLDLSDE EAVHYMQSLI
810 820
DESVHALFAA VVEQIHKFAQ YWRK
Length:824
Mass (Da):94,400
Last modified:June 28, 2011 - v2
Checksum:i32C4721A6B2576F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087683 Genomic DNA No translation available.
AMYH02034608 Genomic DNA No translation available.
KF495756 Genomic DNA No translation available.
RefSeqiNP_001294949.1, NM_001308020.1
UniGeneiHs.464971
Hs.656958

Genome annotation databases

EnsembliENST00000398870; ENSP00000381845; ENSG00000078142
GeneIDi5289
UCSCiuc010xcl.3 human

Similar proteinsi

Entry informationi

Entry nameiA8MYT4_HUMAN
AccessioniPrimary (citable) accession number: A8MYT4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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