ID   CMA1B_HUMAN             Reviewed;         253 AA.
AC   A8MYP8; A0PK18;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Ciliary microtubule associated protein 1B {ECO:0000305};
DE   AltName: Full=Outer dense fiber protein 3-like protein 3;
DE   AltName: Full=Outer dense fiber protein 3B;
GN   Name=CIMAP1B {ECO:0000312|HGNC:HGNC:34388}; Synonyms=ODF3B, ODF3L3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       A8MYP8; P35609: ACTN2; NbExp=3; IntAct=EBI-12010090, EBI-77797;
CC       A8MYP8; Q08043: ACTN3; NbExp=3; IntAct=EBI-12010090, EBI-2880652;
CC       A8MYP8; Q13643: FHL3; NbExp=3; IntAct=EBI-12010090, EBI-741101;
CC       A8MYP8; O75031: HSF2BP; NbExp=3; IntAct=EBI-12010090, EBI-7116203;
CC       A8MYP8; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-12010090, EBI-3957694;
CC       A8MYP8; Q99750: MDFI; NbExp=3; IntAct=EBI-12010090, EBI-724076;
CC       A8MYP8; Q13064: MKRN3; NbExp=3; IntAct=EBI-12010090, EBI-2340269;
CC       A8MYP8; P02549: SPTA1; NbExp=3; IntAct=EBI-12010090, EBI-375617;
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q920N1}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8MYP8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8MYP8-2; Sequence=VSP_034995, VSP_034996, VSP_034997;
CC   -!- SIMILARITY: Belongs to the CIMAP family. {ECO:0000305}.
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DR   EMBL; U62317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC127934; AAI27935.1; -; mRNA.
DR   CCDS; CCDS43039.1; -. [A8MYP8-1]
DR   RefSeq; NP_001014440.2; NM_001014440.3. [A8MYP8-1]
DR   AlphaFoldDB; A8MYP8; -.
DR   SMR; A8MYP8; -.
DR   BioGRID; 136932; 9.
DR   IntAct; A8MYP8; 8.
DR   STRING; 9606.ENSP00000382804; -.
DR   iPTMnet; A8MYP8; -.
DR   PhosphoSitePlus; A8MYP8; -.
DR   BioMuta; ODF3B; -.
DR   EPD; A8MYP8; -.
DR   MassIVE; A8MYP8; -.
DR   PaxDb; 9606-ENSP00000382804; -.
DR   PeptideAtlas; A8MYP8; -.
DR   ProteomicsDB; 2415; -. [A8MYP8-1]
DR   ProteomicsDB; 2416; -. [A8MYP8-2]
DR   Antibodypedia; 53940; 88 antibodies from 11 providers.
DR   DNASU; 440836; -.
DR   Ensembl; ENST00000329363.9; ENSP00000382804.2; ENSG00000177989.14. [A8MYP8-1]
DR   Ensembl; ENST00000682240.1; ENSP00000507825.1; ENSG00000177989.14. [A8MYP8-1]
DR   GeneID; 440836; -.
DR   KEGG; hsa:440836; -.
DR   MANE-Select; ENST00000329363.9; ENSP00000382804.2; NM_001014440.4; NP_001014440.2.
DR   UCSC; uc003bmh.2; human. [A8MYP8-1]
DR   AGR; HGNC:34388; -.
DR   CTD; 440836; -.
DR   DisGeNET; 440836; -.
DR   GeneCards; CIMAP1B; -.
DR   HGNC; HGNC:34388; CIMAP1B.
DR   HPA; ENSG00000177989; Tissue enhanced (choroid plexus, fallopian tube).
DR   neXtProt; NX_A8MYP8; -.
DR   OpenTargets; ENSG00000177989; -.
DR   PharmGKB; PA162398386; -.
DR   VEuPathDB; HostDB:ENSG00000177989; -.
DR   eggNOG; ENOG502QUIJ; Eukaryota.
DR   GeneTree; ENSGT00940000161995; -.
DR   HOGENOM; CLU_088282_1_0_1; -.
DR   InParanoid; A8MYP8; -.
DR   OMA; PHYPERD; -.
DR   OrthoDB; 5473256at2759; -.
DR   PhylomeDB; A8MYP8; -.
DR   TreeFam; TF325804; -.
DR   PathwayCommons; A8MYP8; -.
DR   SignaLink; A8MYP8; -.
DR   BioGRID-ORCS; 440836; 16 hits in 1143 CRISPR screens.
DR   ChiTaRS; ODF3B; human.
DR   GenomeRNAi; 440836; -.
DR   Pharos; A8MYP8; Tbio.
DR   PRO; PR:A8MYP8; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; A8MYP8; Protein.
DR   Bgee; ENSG00000177989; Expressed in right uterine tube and 138 other cell types or tissues.
DR   ExpressionAtlas; A8MYP8; baseline and differential.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010736; SHIPPO-rpt.
DR   PANTHER; PTHR21580:SF19; OUTER DENSE FIBER PROTEIN 3B; 1.
DR   PANTHER; PTHR21580; SHIPPO-1-RELATED; 1.
DR   Pfam; PF07004; SHIPPO-rpt; 6.
DR   Genevisible; A8MYP8; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell projection; Cilium; Flagellum;
KW   Reference proteome.
FT   CHAIN           1..253
FT                   /note="Ciliary microtubule associated protein 1B"
FT                   /id="PRO_0000346440"
FT   REPEAT          182..207
FT                   /note="STPGR"
FT   VAR_SEQ         1..36
FT                   /note="MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT -> MGLGAGPGQTLT
FT                   RMLP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034995"
FT   VAR_SEQ         106..129
FT                   /note="RYFPERAGNATYPSAPRHTIAPRN -> QDPRAPGHPNAELPPGRPTWEPPT
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034996"
FT   VAR_SEQ         130..253
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034997"
SQ   SEQUENCE   253 AA;  27280 MW;  AB7BCC87C5347B5A CRC64;
     MGSDAWVGLW RPHRPRGPIA AHYGGPGPKY KLPPNTGYAL HDPSRPRAPA FTFGARFPTQ
     QTTCGPGPGH LVPARMTVRG TDGAPAYSIY GRPRRSAPFL TPGPGRYFPE RAGNATYPSA
     PRHTIAPRNW GVQAEQQSPG PAAYTVPSLL GPRVIGKVSA PTCSIYGRRA AGSFFEDLSK
     TPGPCAYQVV SPGVYKSRAP QFTILARTSL PQDNTRKPGP AAYNVDQHRK PRGWSFGIRH
     SDYLAPLVTD ADN
//