A8MYP8 (ODF3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer dense fiber protein 3B

Alternative name(s):
Outer dense fiber protein 3-like protein 3

Gene names

Name:	ODF3B
Synonyms:	ODF3L3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ODF3 family. Contains 1 STPGR (Sperm-tail PG-rich) repeat.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A8MYP8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 (identifier: A8MYP8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT → MGLGAGPGQTLTRMLP
     106-129: RYFPERAGNATYPSAPRHTIAPRN → QDPRAPGHPNAELPPGRPTWEPPT
     130-253: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Outer dense fiber protein 3B		PRO_0000346440
Regions
	Repeat	182 – 207	26	STPGR
Natural variations
	Alternative sequence	1 – 36	36	MGSDA…LPPNT → MGLGAGPGQTLTRMLP in isoform 2.		VSP_034995
	Alternative sequence	106 – 129	24	RYFPE…IAPRN → QDPRAPGHPNAELPPGRPTW EPPT in isoform 2.		VSP_034996
	Alternative sequence	130 – 253	124	Missing in isoform 2.		VSP_034997

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: AB7BCC87C5347B5A	FASTA	253	27,280
	10 20 30 40 50 60 MGSDAWVGLW RPHRPRGPIA AHYGGPGPKY KLPPNTGYAL HDPSRPRAPA FTFGARFPTQ 70 80 90 100 110 120 QTTCGPGPGH LVPARMTVRG TDGAPAYSIY GRPRRSAPFL TPGPGRYFPE RAGNATYPSA 130 140 150 160 170 180 PRHTIAPRNW GVQAEQQSPG PAAYTVPSLL GPRVIGKVSA PTCSIYGRRA AGSFFEDLSK 190 200 210 220 230 240 TPGPCAYQVV SPGVYKSRAP QFTILARTSL PQDNTRKPGP AAYNVDQHRK PRGWSFGIRH 250 SDYLAPLVTD ADN
	Isoform 2 [UniParc]. Checksum: 79692E9C77DDFDF4	FASTA	109	11,447
	10 20 30 40 50 60 MGLGAGPGQT LTRMLPGYAL HDPSRPRAPA FTFGARFPTQ QTTCGPGPGH LVPARMTVRG 70 80 90 100 TDGAPAYSIY GRPRRSAPFL TPGPGQDPRA PGHPNAELPP GRPTWEPPT

References

[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62317 Genomic DNA. No translation available. BC127934 mRNA. Translation: AAI27935.1.
IPI	IPI00827954. IPI00877138.
RefSeq	NP_001014440.2. NM_001014440.3.
UniGene	Hs.531314.
3D structure databases
ProteinModelPortal	A8MYP8.
ModBase	Search...
Proteomic databases
PaxDb	A8MYP8.
PRIDE	A8MYP8.
Protocols and materials databases
DNASU	440836.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329363; ENSP00000382804; ENSG00000177989. ENST00000428989; ENSP00000390712; ENSG00000177989.
GeneID	440836.
KEGG	hsa:440836.
UCSC	uc003bmh.2. human.
Organism-specific databases
CTD	440836.
GeneCards	GC22M050968.
HGNC	HGNC:34388. ODF3B.
neXtProt	NX_A8MYP8.
PharmGKB	PA162398386.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72574.
HOGENOM	HOG000090412.
HOVERGEN	HBG054464.
Gene expression databases
ArrayExpress	A8MYP8.
Bgee	A8MYP8.
CleanEx	HS_ODF3B.
Genevestigator	A8MYP8.
Family and domain databases
InterPro	IPR010736. SHIPPO-rpt. [Graphical view]
Pfam	PF07004. SHIPPO-rpt. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ODF3B. human.
GenomeRNAi	440836.
NextBio	109537.

Entry information

Entry name

ODF3B_HUMAN

Accession

Primary (citable) accession number: A8MYP8
Secondary accession number(s): A0PK18

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	December 4, 2007
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.