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Protein

Outer dense fiber protein 3B

Gene

ODF3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 3B
Alternative name(s):
Outer dense fiber protein 3-like protein 3
Gene namesi
Name:ODF3B
Synonyms:ODF3L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:34388. ODF3B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Outer dense fiber protein 3BPRO_0000346440Add
BLAST

Proteomic databases

PaxDbiA8MYP8.
PRIDEiA8MYP8.

Expressioni

Gene expression databases

BgeeiA8MYP8.
CleanExiHS_ODF3B.
ExpressionAtlasiA8MYP8. baseline and differential.
GenevestigatoriA8MYP8.

Organism-specific databases

HPAiHPA062837.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382804.

Structurei

3D structure databases

ProteinModelPortaliA8MYP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati182 – 20726STPGRAdd
BLAST

Sequence similaritiesi

Belongs to the ODF3 family.Curated

Phylogenomic databases

eggNOGiNOG72574.
GeneTreeiENSGT00440000039820.
HOGENOMiHOG000090412.
HOVERGENiHBG054464.
InParanoidiA8MYP8.
PhylomeDBiA8MYP8.
TreeFamiTF325804.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MYP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSDAWVGLW RPHRPRGPIA AHYGGPGPKY KLPPNTGYAL HDPSRPRAPA
60 70 80 90 100
FTFGARFPTQ QTTCGPGPGH LVPARMTVRG TDGAPAYSIY GRPRRSAPFL
110 120 130 140 150
TPGPGRYFPE RAGNATYPSA PRHTIAPRNW GVQAEQQSPG PAAYTVPSLL
160 170 180 190 200
GPRVIGKVSA PTCSIYGRRA AGSFFEDLSK TPGPCAYQVV SPGVYKSRAP
210 220 230 240 250
QFTILARTSL PQDNTRKPGP AAYNVDQHRK PRGWSFGIRH SDYLAPLVTD

ADN

Note: Gene prediction based on EST data.

Length:253
Mass (Da):27,280
Last modified:December 4, 2007 - v1
Checksum:iAB7BCC87C5347B5A
GO
Isoform 2 (identifier: A8MYP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT → MGLGAGPGQTLTRMLP
     106-129: RYFPERAGNATYPSAPRHTIAPRN → QDPRAPGHPNAELPPGRPTWEPPT
     130-253: Missing.

Note: No experimental confirmation available.

Show »
Length:109
Mass (Da):11,447
Checksum:i79692E9C77DDFDF4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636MGSDA…LPPNT → MGLGAGPGQTLTRMLP in isoform 2. 1 PublicationVSP_034995Add
BLAST
Alternative sequencei106 – 12924RYFPE…IAPRN → QDPRAPGHPNAELPPGRPTW EPPT in isoform 2. 1 PublicationVSP_034996Add
BLAST
Alternative sequencei130 – 253124Missing in isoform 2. 1 PublicationVSP_034997Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62317 Genomic DNA. No translation available.
BC127934 mRNA. Translation: AAI27935.1.
CCDSiCCDS43039.1. [A8MYP8-1]
RefSeqiNP_001014440.2. NM_001014440.3. [A8MYP8-1]
XP_005261975.1. XM_005261918.2. [A8MYP8-1]
UniGeneiHs.531314.

Genome annotation databases

EnsembliENST00000329363; ENSP00000382804; ENSG00000177989. [A8MYP8-1]
ENST00000428989; ENSP00000390712; ENSG00000177989. [A8MYP8-1]
GeneIDi440836.
KEGGihsa:440836.
UCSCiuc003bmh.2. human. [A8MYP8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62317 Genomic DNA. No translation available.
BC127934 mRNA. Translation: AAI27935.1.
CCDSiCCDS43039.1. [A8MYP8-1]
RefSeqiNP_001014440.2. NM_001014440.3. [A8MYP8-1]
XP_005261975.1. XM_005261918.2. [A8MYP8-1]
UniGeneiHs.531314.

3D structure databases

ProteinModelPortaliA8MYP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382804.

Proteomic databases

PaxDbiA8MYP8.
PRIDEiA8MYP8.

Protocols and materials databases

DNASUi440836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329363; ENSP00000382804; ENSG00000177989. [A8MYP8-1]
ENST00000428989; ENSP00000390712; ENSG00000177989. [A8MYP8-1]
GeneIDi440836.
KEGGihsa:440836.
UCSCiuc003bmh.2. human. [A8MYP8-1]

Organism-specific databases

CTDi440836.
GeneCardsiGC22M050968.
HGNCiHGNC:34388. ODF3B.
HPAiHPA062837.
neXtProtiNX_A8MYP8.
PharmGKBiPA162398386.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72574.
GeneTreeiENSGT00440000039820.
HOGENOMiHOG000090412.
HOVERGENiHBG054464.
InParanoidiA8MYP8.
PhylomeDBiA8MYP8.
TreeFamiTF325804.

Miscellaneous databases

ChiTaRSiODF3B. human.
GenomeRNAii440836.
NextBioi109537.
PROiA8MYP8.

Gene expression databases

BgeeiA8MYP8.
CleanExiHS_ODF3B.
ExpressionAtlasiA8MYP8. baseline and differential.
GenevestigatoriA8MYP8.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiODF3B_HUMAN
AccessioniPrimary (citable) accession number: A8MYP8
Secondary accession number(s): A0PK18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.