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Protein

Tetratricopeptide repeat protein 34

Gene

TTC34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 34
Short name:
TPR repeat protein 34
Gene namesi
Name:TTC34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:34297. TTC34.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407211.

Polymorphism and mutation databases

BioMutaiTTC34.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Tetratricopeptide repeat protein 34PRO_0000341278Add
BLAST

Proteomic databases

PaxDbiA8MYJ7.
PRIDEiA8MYJ7.

Expressioni

Gene expression databases

BgeeiA8MYJ7.
CleanExiHS_TTC34.

Interactioni

Protein-protein interaction databases

BioGridi939557. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8MYJ7.
SMRiA8MYJ7. Positions 31-104, 183-245, 308-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8334TPR 1Add
BLAST
Repeati178 – 21134TPR 2Add
BLAST
Repeati212 – 24534TPR 3Add
BLAST
Repeati306 – 33934TPR 4Add
BLAST
Repeati341 – 37333TPR 5Add
BLAST
Repeati424 – 45734TPR 6Add
BLAST
Repeati464 – 49734TPR 7Add
BLAST
Repeati512 – 54534TPR 8Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IE0N. Eukaryota.
ENOG410ZKC0. LUCA.
GeneTreeiENSGT00390000003047.
HOGENOMiHOG000154706.
HOVERGENiHBG108612.
InParanoidiA8MYJ7.
OMAiQKKTAIF.
OrthoDBiEOG7M0NR6.
PhylomeDBiA8MYJ7.
TreeFamiTF332803.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MYJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRSPRAGP SRAQGRREAA ETGGPTTQEG VACGVHQLAT LLMELDSEDE
60 70 80 90 100
ASRLLAADAL YRLGRLEETH KALLVALSRR PQAAPVLARL ALLQLRRGFF
110 120 130 140 150
YDANQLVKKL VQSGDTACLQ PTLDVFCHED RQLLQGHCHA RALAILRARP
160 170 180 190 200
GGADGRVHTK EAIAYLSLAI FAAGSQASES LLARARCYGF LGQKKTAMFD
210 220 230 240 250
FNTVLRAEPG NVQALCGRAL VHLALDQLQE AVDDIVSALK LGPGTVVPEL
260 270 280 290 300
RSLKPEAQAL ITQGLYSHCR ALLSQLPDTG APLEDKDTQG LLAVGEALIK
310 320 330 340 350
IDSGQPHWHL LLADILMAQG SYEEAGTHLE KALHRAPTSE AARARLGLLQ
360 370 380 390 400
LKKGDVPGAA RDLQSLAEVD APDLSCLLHL LEASERQSLA QAAAQEAGTL
410 420 430 440 450
LDAGQPRQAL GYCSLSVLAS GSSACHLRLR ATCLAELQEF GRALRDLDHV
460 470 480 490 500
LQEALGDGDL PRRAEDFCRQ GRLLLSLGDE AAAAGAFAQA LKLAPSLAQN
510 520 530 540 550
SLCRQPGRAP TARMFLLRGQ CCLEEQRHAE AWTAVESGLL VDPDHRGLKR
560
LKARIRREAS SGCWLQ
Length:566
Mass (Da):60,903
Last modified:June 10, 2008 - v2
Checksum:i6668E05E87DC3E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592464 Genomic DNA. No translation available.
AL831784 Genomic DNA. No translation available.
DN831537 mRNA. No translation available.
DN831538 mRNA. No translation available.
DY655627 mRNA. No translation available.
CCDSiCCDS55565.1.
RefSeqiNP_001229601.1. NM_001242672.1.
XP_011538759.1. XM_011540457.1.
XP_011544694.1. XM_011546392.1.
UniGeneiHs.632363.

Genome annotation databases

EnsembliENST00000401095; ENSP00000383873; ENSG00000215912.
ENST00000611612; ENSP00000483029; ENSG00000275571.
GeneIDi100287898.
KEGGihsa:100287898.
UCSCiuc021oey.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592464 Genomic DNA. No translation available.
AL831784 Genomic DNA. No translation available.
DN831537 mRNA. No translation available.
DN831538 mRNA. No translation available.
DY655627 mRNA. No translation available.
CCDSiCCDS55565.1.
RefSeqiNP_001229601.1. NM_001242672.1.
XP_011538759.1. XM_011540457.1.
XP_011544694.1. XM_011546392.1.
UniGeneiHs.632363.

3D structure databases

ProteinModelPortaliA8MYJ7.
SMRiA8MYJ7. Positions 31-104, 183-245, 308-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi939557. 1 interaction.

Polymorphism and mutation databases

BioMutaiTTC34.

Proteomic databases

PaxDbiA8MYJ7.
PRIDEiA8MYJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401095; ENSP00000383873; ENSG00000215912.
ENST00000611612; ENSP00000483029; ENSG00000275571.
GeneIDi100287898.
KEGGihsa:100287898.
UCSCiuc021oey.2. human.

Organism-specific databases

CTDi100287898.
GeneCardsiTTC34.
HGNCiHGNC:34297. TTC34.
neXtProtiNX_A8MYJ7.
PharmGKBiPA162407211.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE0N. Eukaryota.
ENOG410ZKC0. LUCA.
GeneTreeiENSGT00390000003047.
HOGENOMiHOG000154706.
HOVERGENiHBG108612.
InParanoidiA8MYJ7.
OMAiQKKTAIF.
OrthoDBiEOG7M0NR6.
PhylomeDBiA8MYJ7.
TreeFamiTF332803.

Miscellaneous databases

GenomeRNAii100287898.
NextBioi20777647.
PROiA8MYJ7.

Gene expression databases

BgeeiA8MYJ7.
CleanExiHS_TTC34.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-190.

Entry informationi

Entry nameiTTC34_HUMAN
AccessioniPrimary (citable) accession number: A8MYJ7
Secondary accession number(s): A8MXL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.